Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer
Background The current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipulate microRNA (miR)-218-5p/FTO-N6-methyladenosine (m6A)/MYC signal axis in liver metastasis in colorectal cancer (CRC). Methods hsa_circ_0001739 and lncRNA AC159540.1...
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| Veröffentlicht in: | Cell biology and toxicology 2023-12, Vol.39 (6), p.2551-2568 |
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| creator | Yue, Cai-Feng Chen, Ju-Gao Li, Zi-Yue Li, Lai-Sheng Chen, Jie-Rong Xie, Hai-Xia Zhang, Bin Guo, Yun-Miao |
| description | Background
The current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipulate microRNA (miR)-218-5p/FTO-N6-methyladenosine (m6A)/MYC signal axis in liver metastasis in colorectal cancer (CRC).
Methods
hsa_circ_0001739 and lncRNA AC159540.1 were identified as the upstream regulator of miR-218-5p using ENCORI and LncBase databases. Expression patterns of miR-218-5p, hsa_circ_0001739, lncRNA AC159540.1, FTO, and MYC were detected, accompanied by loss-and-gain-of function assays to examine their effects on CRC cell biological functions. SW480 cells-derived Exos were purified, followed by in vitro studies to uncover the effect of hsa_circ_0001739/lncRNA AC159540.
Results
miR-218-5p was downregulated while hsa_circ_0001739/lncRNA AC159540.1 was upregulated in CRC tissues and cells. Silencing of hsa_circ_0001739/lncRNA AC159540.1 restrained the malignant phenotypes of CRC cells. Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 competitively inhibited miR-218-5p to elevate FTO and MYC. The inducing role of Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 in CRC was also validated
in vivo
.
Conclusion
Conclusively, Exos-mediated circ_0001739/lncRNA AC159540.1 regulatory network is critical for CRC, offering a theoretical basis for CRC treatment.
Graphical abstract |
| doi_str_mv | 10.1007/s10565-023-09837-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2889997596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2896135347</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-36fff651ab721e70b67721e8c00f045666a8c87d414c9adee81ad078337d20a43</originalsourceid><addsrcrecordid>eNp9kV1rFTEQhoMo9tj6B7yQgDfexE6Szdfl4eAXlBakvQ452dmasrupya7Yf2-Opyp4IQQmkOd9ZzIvIa84vOMA5rxyUFoxEJKBs9Iw8YRsuDKSaSvEU7IB0wkmwPET8qLWOwDQ3Kjn5EQap0xn9YY8XK9TLjTiOLIeS_qOPcUfueYJK52wT2FJ8y39WoOPqUTfPLiR7nyc45fLLd3uuHKqawPRIcQ0piUsSMdmU5p6CbWdVGmaacxjLhiXMNIY5ojljDwbwljx5WM9JTcf3l_vPrGLq4-fd9sLFqXQC5N6GAateNgbwdHAXpvDxUaAATqltQ42WtN3vIsu9IiWhx6MldL0AkInT8nbo-99yd9WrIufUj38N8yY1-qFtc45o5xu6Jt_0Lu8lrlN1yinuVSyM40SRyqWXGvBwd-XNIXy4Dn4QzD-GIxvwfhfwXjRRK8frdd9W-sfye8kGiCPQG1P8y2Wv73_Y_sTxEmW2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2896135347</pqid></control><display><type>article</type><title>Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yue, Cai-Feng ; Chen, Ju-Gao ; Li, Zi-Yue ; Li, Lai-Sheng ; Chen, Jie-Rong ; Xie, Hai-Xia ; Zhang, Bin ; Guo, Yun-Miao</creator><creatorcontrib>Yue, Cai-Feng ; Chen, Ju-Gao ; Li, Zi-Yue ; Li, Lai-Sheng ; Chen, Jie-Rong ; Xie, Hai-Xia ; Zhang, Bin ; Guo, Yun-Miao</creatorcontrib><description>Background
The current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipulate microRNA (miR)-218-5p/FTO-N6-methyladenosine (m6A)/MYC signal axis in liver metastasis in colorectal cancer (CRC).
Methods
hsa_circ_0001739 and lncRNA AC159540.1 were identified as the upstream regulator of miR-218-5p using ENCORI and LncBase databases. Expression patterns of miR-218-5p, hsa_circ_0001739, lncRNA AC159540.1, FTO, and MYC were detected, accompanied by loss-and-gain-of function assays to examine their effects on CRC cell biological functions. SW480 cells-derived Exos were purified, followed by in vitro studies to uncover the effect of hsa_circ_0001739/lncRNA AC159540.
Results
miR-218-5p was downregulated while hsa_circ_0001739/lncRNA AC159540.1 was upregulated in CRC tissues and cells. Silencing of hsa_circ_0001739/lncRNA AC159540.1 restrained the malignant phenotypes of CRC cells. Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 competitively inhibited miR-218-5p to elevate FTO and MYC. The inducing role of Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 in CRC was also validated
in vivo
.
Conclusion
Conclusively, Exos-mediated circ_0001739/lncRNA AC159540.1 regulatory network is critical for CRC, offering a theoretical basis for CRC treatment.
Graphical abstract</description><identifier>ISSN: 0742-2091</identifier><identifier>ISSN: 1573-6822</identifier><identifier>EISSN: 1573-6822</identifier><identifier>DOI: 10.1007/s10565-023-09837-2</identifier><identifier>PMID: 37957486</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Biochemistry ; Biomedical and Life Sciences ; Cancer ; Cell Biology ; Cell Proliferation - genetics ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - genetics ; Exosomes ; Exosomes - genetics ; Humans ; Life Sciences ; Liver ; Liver cancer ; Liver Neoplasms - genetics ; Metastases ; Metastasis ; MicroRNAs - genetics ; miRNA ; Myc protein ; N6-methyladenosine ; Non-coding RNA ; Original Article ; Pharmacology/Toxicology ; Phenotypes ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; Tumors</subject><ispartof>Cell biology and toxicology, 2023-12, Vol.39 (6), p.2551-2568</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-36fff651ab721e70b67721e8c00f045666a8c87d414c9adee81ad078337d20a43</cites><orcidid>0000-0001-6056-6266</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10565-023-09837-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10565-023-09837-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37957486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yue, Cai-Feng</creatorcontrib><creatorcontrib>Chen, Ju-Gao</creatorcontrib><creatorcontrib>Li, Zi-Yue</creatorcontrib><creatorcontrib>Li, Lai-Sheng</creatorcontrib><creatorcontrib>Chen, Jie-Rong</creatorcontrib><creatorcontrib>Xie, Hai-Xia</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Guo, Yun-Miao</creatorcontrib><title>Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer</title><title>Cell biology and toxicology</title><addtitle>Cell Biol Toxicol</addtitle><addtitle>Cell Biol Toxicol</addtitle><description>Background
The current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipulate microRNA (miR)-218-5p/FTO-N6-methyladenosine (m6A)/MYC signal axis in liver metastasis in colorectal cancer (CRC).
Methods
hsa_circ_0001739 and lncRNA AC159540.1 were identified as the upstream regulator of miR-218-5p using ENCORI and LncBase databases. Expression patterns of miR-218-5p, hsa_circ_0001739, lncRNA AC159540.1, FTO, and MYC were detected, accompanied by loss-and-gain-of function assays to examine their effects on CRC cell biological functions. SW480 cells-derived Exos were purified, followed by in vitro studies to uncover the effect of hsa_circ_0001739/lncRNA AC159540.
Results
miR-218-5p was downregulated while hsa_circ_0001739/lncRNA AC159540.1 was upregulated in CRC tissues and cells. Silencing of hsa_circ_0001739/lncRNA AC159540.1 restrained the malignant phenotypes of CRC cells. Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 competitively inhibited miR-218-5p to elevate FTO and MYC. The inducing role of Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 in CRC was also validated
in vivo
.
Conclusion
Conclusively, Exos-mediated circ_0001739/lncRNA AC159540.1 regulatory network is critical for CRC, offering a theoretical basis for CRC treatment.
Graphical abstract</description><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell Proliferation - genetics</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Exosomes</subject><subject>Exosomes - genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Myc protein</subject><subject>N6-methyladenosine</subject><subject>Non-coding RNA</subject><subject>Original Article</subject><subject>Pharmacology/Toxicology</subject><subject>Phenotypes</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Tumors</subject><issn>0742-2091</issn><issn>1573-6822</issn><issn>1573-6822</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kV1rFTEQhoMo9tj6B7yQgDfexE6Szdfl4eAXlBakvQ452dmasrupya7Yf2-Opyp4IQQmkOd9ZzIvIa84vOMA5rxyUFoxEJKBs9Iw8YRsuDKSaSvEU7IB0wkmwPET8qLWOwDQ3Kjn5EQap0xn9YY8XK9TLjTiOLIeS_qOPcUfueYJK52wT2FJ8y39WoOPqUTfPLiR7nyc45fLLd3uuHKqawPRIcQ0piUsSMdmU5p6CbWdVGmaacxjLhiXMNIY5ojljDwbwljx5WM9JTcf3l_vPrGLq4-fd9sLFqXQC5N6GAateNgbwdHAXpvDxUaAATqltQ42WtN3vIsu9IiWhx6MldL0AkInT8nbo-99yd9WrIufUj38N8yY1-qFtc45o5xu6Jt_0Lu8lrlN1yinuVSyM40SRyqWXGvBwd-XNIXy4Dn4QzD-GIxvwfhfwXjRRK8frdd9W-sfye8kGiCPQG1P8y2Wv73_Y_sTxEmW2A</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Yue, Cai-Feng</creator><creator>Chen, Ju-Gao</creator><creator>Li, Zi-Yue</creator><creator>Li, Lai-Sheng</creator><creator>Chen, Jie-Rong</creator><creator>Xie, Hai-Xia</creator><creator>Zhang, Bin</creator><creator>Guo, Yun-Miao</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6056-6266</orcidid></search><sort><creationdate>20231201</creationdate><title>Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer</title><author>Yue, Cai-Feng ; Chen, Ju-Gao ; Li, Zi-Yue ; Li, Lai-Sheng ; Chen, Jie-Rong ; Xie, Hai-Xia ; Zhang, Bin ; Guo, Yun-Miao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-36fff651ab721e70b67721e8c00f045666a8c87d414c9adee81ad078337d20a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cell Proliferation - genetics</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Exosomes</topic><topic>Exosomes - genetics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Myc protein</topic><topic>N6-methyladenosine</topic><topic>Non-coding RNA</topic><topic>Original Article</topic><topic>Pharmacology/Toxicology</topic><topic>Phenotypes</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yue, Cai-Feng</creatorcontrib><creatorcontrib>Chen, Ju-Gao</creatorcontrib><creatorcontrib>Li, Zi-Yue</creatorcontrib><creatorcontrib>Li, Lai-Sheng</creatorcontrib><creatorcontrib>Chen, Jie-Rong</creatorcontrib><creatorcontrib>Xie, Hai-Xia</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Guo, Yun-Miao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biology and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yue, Cai-Feng</au><au>Chen, Ju-Gao</au><au>Li, Zi-Yue</au><au>Li, Lai-Sheng</au><au>Chen, Jie-Rong</au><au>Xie, Hai-Xia</au><au>Zhang, Bin</au><au>Guo, Yun-Miao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer</atitle><jtitle>Cell biology and toxicology</jtitle><stitle>Cell Biol Toxicol</stitle><addtitle>Cell Biol Toxicol</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>39</volume><issue>6</issue><spage>2551</spage><epage>2568</epage><pages>2551-2568</pages><issn>0742-2091</issn><issn>1573-6822</issn><eissn>1573-6822</eissn><abstract>Background
The current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipulate microRNA (miR)-218-5p/FTO-N6-methyladenosine (m6A)/MYC signal axis in liver metastasis in colorectal cancer (CRC).
Methods
hsa_circ_0001739 and lncRNA AC159540.1 were identified as the upstream regulator of miR-218-5p using ENCORI and LncBase databases. Expression patterns of miR-218-5p, hsa_circ_0001739, lncRNA AC159540.1, FTO, and MYC were detected, accompanied by loss-and-gain-of function assays to examine their effects on CRC cell biological functions. SW480 cells-derived Exos were purified, followed by in vitro studies to uncover the effect of hsa_circ_0001739/lncRNA AC159540.
Results
miR-218-5p was downregulated while hsa_circ_0001739/lncRNA AC159540.1 was upregulated in CRC tissues and cells. Silencing of hsa_circ_0001739/lncRNA AC159540.1 restrained the malignant phenotypes of CRC cells. Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 competitively inhibited miR-218-5p to elevate FTO and MYC. The inducing role of Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 in CRC was also validated
in vivo
.
Conclusion
Conclusively, Exos-mediated circ_0001739/lncRNA AC159540.1 regulatory network is critical for CRC, offering a theoretical basis for CRC treatment.
Graphical abstract</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>37957486</pmid><doi>10.1007/s10565-023-09837-2</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0001-6056-6266</orcidid></addata></record> |
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| subjects | Alpha-Ketoglutarate-Dependent Dioxygenase FTO Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Proliferation - genetics Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Exosomes Exosomes - genetics Humans Life Sciences Liver Liver cancer Liver Neoplasms - genetics Metastases Metastasis MicroRNAs - genetics miRNA Myc protein N6-methyladenosine Non-coding RNA Original Article Pharmacology/Toxicology Phenotypes Ribonucleic acid RNA RNA, Long Noncoding - genetics Tumors |
| title | Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer |
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