Ophthalmic Bimatoprost-Loaded Niosomal In Situ Gel: Preparation, Optimization, and In Vivo Pharmacodynamics Study

This study aimed at formulating the antiglaucoma agent, Bimatoprost (BMT), into niosomal in situ gel (BMT-ISG) for ocular delivery. Niosomes containing cholesterol/span 60 entrapping BMT were fabricated using a thin-film hydration method. The fabricated niosomes were optimized and characterized for...

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Veröffentlicht in:	Polymers 2023-11, Vol.15 (21), p.4336
Hauptverfasser:	Aldawsari, Mohammed F, Moglad, Ehssan H, Alotaibi, Hadil Faris, Alkahtani, Hamad M, Khafagy, El-Sayed
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Aqueous solutions Bimatoprost Bioavailability Cellulose Cholesterol Cornea Dosage and administration Drug delivery systems Drug dosages Efficiency Entrapment Fourier transforms Gels Gels (Pharmacy) Glaucoma Identification and classification In vivo methods and tests Intraocular pressure Irritation Nanoparticles Optimization Pharmacology Poloxamers Polymers Properties Rabbits Sol-gel processes Spectrum analysis Thin films
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