Contact lens wear and follow‐up and its association with signs and symptoms of meibomian gland dysfunction
Introduction This study investigated the equivocal association between contact lens (CL) wear and meibomian gland dysfunction (MGD) by comparing the morphological, functional and subjective outcomes of CL wearers versus control, non‐CL wearers. CL wearers were examined as two cohorts based on the an...
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| Veröffentlicht in: | Ophthalmic & physiological optics 2024-01, Vol.44 (1), p.153-167 |
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| creator | Ifrah, Reut Quevedo, Lluisa Hazrati, Gal Maman, Shiran Mangisto, Huluager Shmuel, Eden Gantz, Liat |
| description | Introduction
This study investigated the equivocal association between contact lens (CL) wear and meibomian gland dysfunction (MGD) by comparing the morphological, functional and subjective outcomes of CL wearers versus control, non‐CL wearers. CL wearers were examined as two cohorts based on the annual attendance of follow‐up visits (FLU—attended these visits, whereas non‐FLU did not).
Methods
Habitual logMAR visual acuity, invasive and non‐invasive tear break‐up time, Schirmer test, Efron grading scales, meibum quality score (MQS), meibum expressibility score (MES), meibomian gland (MG) loss, lid margin abnormalities and subjective dry eye (DE) symptoms were assessed.
Results
Of the 128 participants, 31 were in the FLU cohort, 43 were in the non‐FLU cohort and 54 were controls (mean ages: 22.2 ± 3.1, 23.0 ± 4.6 and 22.3 ± 3.5, respectively). Non‐FLU CL wearers had more symptoms than controls (3.7 ± 2.4 vs. 2.3 ± 2.1, p |
| doi_str_mv | 10.1111/opo.13247 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2889993537</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2889993537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3487-2282329a08208d82bab4605852baec5d2550164f312e8f0d73c05bec25cb55b03</originalsourceid><addsrcrecordid>eNp1kUtOwzAQhi0EouWx4ALIEhtYpPUjrp0lqnhJlcoC1pHjOMVVEoc4UZQdR-CMnASnKSyQmM3MaL75NZofgAuMZtjH3FZ2hikJ-QGY4pCzAFNMD8EUEV-zEIkJOHFuixDinItjMKE8WhASsSnIl7ZspGpgrksHOy1rKMsUZjbPbff18dlWu940DkrnrDKyMbaEnWneoDMbvzOMXV9UjS0ctBkstElsYWQJN_kwS3uXtaUa1s7AUSZzp8_3-RS83t-9LB-D1frhaXm7ChQNBQ8IEYSSSCJBkEgFSWQSLhATzFdasZQwhvAizCgmWmQo5VQhlmhFmEoYSxA9BdejblXb91a7Ji6MUzr392jbupgIEUURZZR79OoPurVtXfrrPBVFTGDEFp66GSlVW-dqncVVbQpZ9zFG8WBB7C2IdxZ49nKv2CaFTn_Jn597YD4Cncl1_79SvH5ej5Lf9rSRGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2899581056</pqid></control><display><type>article</type><title>Contact lens wear and follow‐up and its association with signs and symptoms of meibomian gland dysfunction</title><source>Wiley Online Library All Journals</source><creator>Ifrah, Reut ; Quevedo, Lluisa ; Hazrati, Gal ; Maman, Shiran ; Mangisto, Huluager ; Shmuel, Eden ; Gantz, Liat</creator><creatorcontrib>Ifrah, Reut ; Quevedo, Lluisa ; Hazrati, Gal ; Maman, Shiran ; Mangisto, Huluager ; Shmuel, Eden ; Gantz, Liat</creatorcontrib><description>Introduction
This study investigated the equivocal association between contact lens (CL) wear and meibomian gland dysfunction (MGD) by comparing the morphological, functional and subjective outcomes of CL wearers versus control, non‐CL wearers. CL wearers were examined as two cohorts based on the annual attendance of follow‐up visits (FLU—attended these visits, whereas non‐FLU did not).
Methods
Habitual logMAR visual acuity, invasive and non‐invasive tear break‐up time, Schirmer test, Efron grading scales, meibum quality score (MQS), meibum expressibility score (MES), meibomian gland (MG) loss, lid margin abnormalities and subjective dry eye (DE) symptoms were assessed.
Results
Of the 128 participants, 31 were in the FLU cohort, 43 were in the non‐FLU cohort and 54 were controls (mean ages: 22.2 ± 3.1, 23.0 ± 4.6 and 22.3 ± 3.5, respectively). Non‐FLU CL wearers had more symptoms than controls (3.7 ± 2.4 vs. 2.3 ± 2.1, p < 0.01). Morphologically, FLU (16.9 ± 8.8%, p = 0.02) and non‐FLU (18.6 ± 11.3%, p = 0.001) had more MG loss than controls (11.2 ± 6.8%). Functionally, FLU (0.6 ± 0.7, p = 0.01) and non‐FLU (0.8 ± 0.9, p = 0.001) had worse MES than controls (0.2 ± 0.5). FLU and non‐FLU were both associated with corneal staining (odds ratio [OR] = 3.42, 95% CI: 1.16–10.11, p = 0.03 and OR = 5.23, 95% CI: 1.89–14.48, p = 0.001, respectively) and MG loss (OR = 10.47, 95% CI: 1.14–96.29, p = 0.04 and OR = 16.63, 95% CI: 1.96–140.86, p = 0.01, respectively). Non‐FLU CL wear was also associated with abnormal MQS (OR = 12.87, 95% CI: 1.12–148.41, p = 0.04), conjunctival staining (OR = 12.18, 95% CI: 3.66–40.51, p < 0.001) and lid margin telangiectasia (OR = 3.78, 95% CI: 1.55–9.21, p = 0.003). MGD was three times more prevalent in CL wearers (12%) than in controls (4%).
Conclusions
Both CL‐wearing cohorts demonstrated significantly more MG abnormalities than controls though the difference was not clinically significant. Non‐FLU CL wearers had more DE symptoms. Non‐FLU CL wear is an independent predictor for more abnormalities than FLU CL wear, emphasising the importance of follow‐ups.</description><identifier>ISSN: 0275-5408</identifier><identifier>EISSN: 1475-1313</identifier><identifier>DOI: 10.1111/opo.13247</identifier><identifier>PMID: 37962295</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acuity ; Contact lenses ; contact‐lens complications ; Cornea ; follow‐up ; Glands ; Influenza ; meibomian gland dysfunction ; meibomian glands</subject><ispartof>Ophthalmic & physiological optics, 2024-01, Vol.44 (1), p.153-167</ispartof><rights>2023 College of Optometrists.</rights><rights>Copyright © 2024 The College of Optometrists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3487-2282329a08208d82bab4605852baec5d2550164f312e8f0d73c05bec25cb55b03</cites><orcidid>0000-0001-7924-0610 ; 0000-0002-9604-3528</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fopo.13247$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fopo.13247$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37962295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ifrah, Reut</creatorcontrib><creatorcontrib>Quevedo, Lluisa</creatorcontrib><creatorcontrib>Hazrati, Gal</creatorcontrib><creatorcontrib>Maman, Shiran</creatorcontrib><creatorcontrib>Mangisto, Huluager</creatorcontrib><creatorcontrib>Shmuel, Eden</creatorcontrib><creatorcontrib>Gantz, Liat</creatorcontrib><title>Contact lens wear and follow‐up and its association with signs and symptoms of meibomian gland dysfunction</title><title>Ophthalmic & physiological optics</title><addtitle>Ophthalmic Physiol Opt</addtitle><description>Introduction
This study investigated the equivocal association between contact lens (CL) wear and meibomian gland dysfunction (MGD) by comparing the morphological, functional and subjective outcomes of CL wearers versus control, non‐CL wearers. CL wearers were examined as two cohorts based on the annual attendance of follow‐up visits (FLU—attended these visits, whereas non‐FLU did not).
Methods
Habitual logMAR visual acuity, invasive and non‐invasive tear break‐up time, Schirmer test, Efron grading scales, meibum quality score (MQS), meibum expressibility score (MES), meibomian gland (MG) loss, lid margin abnormalities and subjective dry eye (DE) symptoms were assessed.
Results
Of the 128 participants, 31 were in the FLU cohort, 43 were in the non‐FLU cohort and 54 were controls (mean ages: 22.2 ± 3.1, 23.0 ± 4.6 and 22.3 ± 3.5, respectively). Non‐FLU CL wearers had more symptoms than controls (3.7 ± 2.4 vs. 2.3 ± 2.1, p < 0.01). Morphologically, FLU (16.9 ± 8.8%, p = 0.02) and non‐FLU (18.6 ± 11.3%, p = 0.001) had more MG loss than controls (11.2 ± 6.8%). Functionally, FLU (0.6 ± 0.7, p = 0.01) and non‐FLU (0.8 ± 0.9, p = 0.001) had worse MES than controls (0.2 ± 0.5). FLU and non‐FLU were both associated with corneal staining (odds ratio [OR] = 3.42, 95% CI: 1.16–10.11, p = 0.03 and OR = 5.23, 95% CI: 1.89–14.48, p = 0.001, respectively) and MG loss (OR = 10.47, 95% CI: 1.14–96.29, p = 0.04 and OR = 16.63, 95% CI: 1.96–140.86, p = 0.01, respectively). Non‐FLU CL wear was also associated with abnormal MQS (OR = 12.87, 95% CI: 1.12–148.41, p = 0.04), conjunctival staining (OR = 12.18, 95% CI: 3.66–40.51, p < 0.001) and lid margin telangiectasia (OR = 3.78, 95% CI: 1.55–9.21, p = 0.003). MGD was three times more prevalent in CL wearers (12%) than in controls (4%).
Conclusions
Both CL‐wearing cohorts demonstrated significantly more MG abnormalities than controls though the difference was not clinically significant. Non‐FLU CL wearers had more DE symptoms. Non‐FLU CL wear is an independent predictor for more abnormalities than FLU CL wear, emphasising the importance of follow‐ups.</description><subject>Acuity</subject><subject>Contact lenses</subject><subject>contact‐lens complications</subject><subject>Cornea</subject><subject>follow‐up</subject><subject>Glands</subject><subject>Influenza</subject><subject>meibomian gland dysfunction</subject><subject>meibomian glands</subject><issn>0275-5408</issn><issn>1475-1313</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kUtOwzAQhi0EouWx4ALIEhtYpPUjrp0lqnhJlcoC1pHjOMVVEoc4UZQdR-CMnASnKSyQmM3MaL75NZofgAuMZtjH3FZ2hikJ-QGY4pCzAFNMD8EUEV-zEIkJOHFuixDinItjMKE8WhASsSnIl7ZspGpgrksHOy1rKMsUZjbPbff18dlWu940DkrnrDKyMbaEnWneoDMbvzOMXV9UjS0ctBkstElsYWQJN_kwS3uXtaUa1s7AUSZzp8_3-RS83t-9LB-D1frhaXm7ChQNBQ8IEYSSSCJBkEgFSWQSLhATzFdasZQwhvAizCgmWmQo5VQhlmhFmEoYSxA9BdejblXb91a7Ji6MUzr392jbupgIEUURZZR79OoPurVtXfrrPBVFTGDEFp66GSlVW-dqncVVbQpZ9zFG8WBB7C2IdxZ49nKv2CaFTn_Jn597YD4Cncl1_79SvH5ej5Lf9rSRGA</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Ifrah, Reut</creator><creator>Quevedo, Lluisa</creator><creator>Hazrati, Gal</creator><creator>Maman, Shiran</creator><creator>Mangisto, Huluager</creator><creator>Shmuel, Eden</creator><creator>Gantz, Liat</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7924-0610</orcidid><orcidid>https://orcid.org/0000-0002-9604-3528</orcidid></search><sort><creationdate>202401</creationdate><title>Contact lens wear and follow‐up and its association with signs and symptoms of meibomian gland dysfunction</title><author>Ifrah, Reut ; Quevedo, Lluisa ; Hazrati, Gal ; Maman, Shiran ; Mangisto, Huluager ; Shmuel, Eden ; Gantz, Liat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3487-2282329a08208d82bab4605852baec5d2550164f312e8f0d73c05bec25cb55b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acuity</topic><topic>Contact lenses</topic><topic>contact‐lens complications</topic><topic>Cornea</topic><topic>follow‐up</topic><topic>Glands</topic><topic>Influenza</topic><topic>meibomian gland dysfunction</topic><topic>meibomian glands</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ifrah, Reut</creatorcontrib><creatorcontrib>Quevedo, Lluisa</creatorcontrib><creatorcontrib>Hazrati, Gal</creatorcontrib><creatorcontrib>Maman, Shiran</creatorcontrib><creatorcontrib>Mangisto, Huluager</creatorcontrib><creatorcontrib>Shmuel, Eden</creatorcontrib><creatorcontrib>Gantz, Liat</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmic & physiological optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ifrah, Reut</au><au>Quevedo, Lluisa</au><au>Hazrati, Gal</au><au>Maman, Shiran</au><au>Mangisto, Huluager</au><au>Shmuel, Eden</au><au>Gantz, Liat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contact lens wear and follow‐up and its association with signs and symptoms of meibomian gland dysfunction</atitle><jtitle>Ophthalmic & physiological optics</jtitle><addtitle>Ophthalmic Physiol Opt</addtitle><date>2024-01</date><risdate>2024</risdate><volume>44</volume><issue>1</issue><spage>153</spage><epage>167</epage><pages>153-167</pages><issn>0275-5408</issn><eissn>1475-1313</eissn><abstract>Introduction
This study investigated the equivocal association between contact lens (CL) wear and meibomian gland dysfunction (MGD) by comparing the morphological, functional and subjective outcomes of CL wearers versus control, non‐CL wearers. CL wearers were examined as two cohorts based on the annual attendance of follow‐up visits (FLU—attended these visits, whereas non‐FLU did not).
Methods
Habitual logMAR visual acuity, invasive and non‐invasive tear break‐up time, Schirmer test, Efron grading scales, meibum quality score (MQS), meibum expressibility score (MES), meibomian gland (MG) loss, lid margin abnormalities and subjective dry eye (DE) symptoms were assessed.
Results
Of the 128 participants, 31 were in the FLU cohort, 43 were in the non‐FLU cohort and 54 were controls (mean ages: 22.2 ± 3.1, 23.0 ± 4.6 and 22.3 ± 3.5, respectively). Non‐FLU CL wearers had more symptoms than controls (3.7 ± 2.4 vs. 2.3 ± 2.1, p < 0.01). Morphologically, FLU (16.9 ± 8.8%, p = 0.02) and non‐FLU (18.6 ± 11.3%, p = 0.001) had more MG loss than controls (11.2 ± 6.8%). Functionally, FLU (0.6 ± 0.7, p = 0.01) and non‐FLU (0.8 ± 0.9, p = 0.001) had worse MES than controls (0.2 ± 0.5). FLU and non‐FLU were both associated with corneal staining (odds ratio [OR] = 3.42, 95% CI: 1.16–10.11, p = 0.03 and OR = 5.23, 95% CI: 1.89–14.48, p = 0.001, respectively) and MG loss (OR = 10.47, 95% CI: 1.14–96.29, p = 0.04 and OR = 16.63, 95% CI: 1.96–140.86, p = 0.01, respectively). Non‐FLU CL wear was also associated with abnormal MQS (OR = 12.87, 95% CI: 1.12–148.41, p = 0.04), conjunctival staining (OR = 12.18, 95% CI: 3.66–40.51, p < 0.001) and lid margin telangiectasia (OR = 3.78, 95% CI: 1.55–9.21, p = 0.003). MGD was three times more prevalent in CL wearers (12%) than in controls (4%).
Conclusions
Both CL‐wearing cohorts demonstrated significantly more MG abnormalities than controls though the difference was not clinically significant. Non‐FLU CL wearers had more DE symptoms. Non‐FLU CL wear is an independent predictor for more abnormalities than FLU CL wear, emphasising the importance of follow‐ups.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37962295</pmid><doi>10.1111/opo.13247</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-7924-0610</orcidid><orcidid>https://orcid.org/0000-0002-9604-3528</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acuity Contact lenses contact‐lens complications Cornea follow‐up Glands Influenza meibomian gland dysfunction meibomian glands |
| title | Contact lens wear and follow‐up and its association with signs and symptoms of meibomian gland dysfunction |
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