Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift
To visualize the guanine-quadruplex (G4) nucleic acids in cells or in biological tissues, near-infrared (NIR) fluorescent probes that can respond specifically to G4 nucleic acids are required. Herein, an NIR fluorescence switch-on probe for G4 imaging having higher selectivity and extremely large St...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2023-11, Vol.95 (47), p.17162-17165 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Muraoka, Yuka Muramoto, Junya Yasuhara, Yu Kawatake, Mayuko Sakamoto, Takashi |
| description | To visualize the guanine-quadruplex (G4) nucleic acids in cells or in biological tissues, near-infrared (NIR) fluorescent probes that can respond specifically to G4 nucleic acids are required. Herein, an NIR fluorescence switch-on probe for G4 imaging having higher selectivity and extremely large Stokes shift (ca. 220 nm) was successfully developed by the modification of our original tripodal quinone-cyanine fluorescent dye. The target binding-induced intramolecular stacking interaction of the probe might cause red shifting of the fluorescence emission. The NIR fluorescence switch-on probe developed here might contribute largely to revealing the behaviors of G4 nucleic acids not only in cells but also in biological tissues. |
| doi_str_mv | 10.1021/acs.analchem.3c04318 |
| format | Article |
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| subjects | Fluorescence Fluorescent Dyes Fluorescent indicators I.R. radiation Near infrared radiation Nucleic Acids Optical Imaging Quinones Tissues |
| title | Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift |
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