Signatures of tRNAGlx‐specificity in proteobacterial glutamyl‐tRNA synthetases

The canonical function of glutamyl‐tRNA synthetase (GluRS) is to glutamylate tRNAGlu. Yet not all bacterial GluRSs glutamylate tRNAGlu; many glutamylate both tRNAGlu and tRNAGln, while some glutamylate only tRNAGln and not the cognate substrate tRNAGlu. Understanding the basis of the unique specific...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2025-01, Vol.93 (1), p.241-254
Hauptverfasser:	Dasgupta, Saumya, Dev, Aditya, Chongdar, Nipa, Basak, Premananda, Dastidar, Shubhra Ghosh, Basu, Gautam
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodiversity hot spots Crystal structure E coli GluRS Glutamate receptors Mutation hot spots protein‐RNA interaction proteobacteria Recombination hot spots Signatures Transfer RNA tRNA tRNA‐discrimination tRNA‐Gln
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