Oxidized thioredoxin 1 places a leash on NLRP1 inflammasome activity

The biology of the NACHT domain and leucine‐rich repeat (NLR) and pyrin domain‐containing 1 (NLRP1) inflammasome has perplexed researchers since this inflammasome was first described about two decades ago. The identification of oxidized thioredoxin 1 (TRX1) as a suppressor of NLRP1 recently linked c...

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Veröffentlicht in:	Immunology and cell biology 2024-01, Vol.102 (1), p.5-7
Hauptverfasser:	Yap, Jeremy KY, Emming, Stefan, Schroder, Kate
Format:	Artikel
Sprache:	eng
Schlagworte:	Drug development Homeostasis Inflammasomes Inflammation NACHT domain Pyrin protein signaling structure Thioredoxin TRX1‐bound NLRP1 inflammasome
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