Full-Length NAD + -I Riboswitches Bind a Single Cofactor but Cannot Discriminate against Adenosine Triphosphate

Bacterial riboswitches are structured RNAs that bind small metabolites to control downstream gene expression. Two riboswitch classes have been reported to sense nicotinamide adenine dinucleotide (NAD ), which plays a key redox role in cellular metabolism. The NAD -I (class I) riboswitch stands out b...

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Veröffentlicht in:	Biochemistry (Easton) 2023-12, Vol.62 (23), p.3396-3410
Hauptverfasser:	Srivastava, Yoshita, Blau, Maya E, Jenkins, Jermaine L, Wedekind, Joseph E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate Ligands NAD - metabolism Nucleic Acid Conformation Ribavirin Riboswitch
Online-Zugang:	Volltext
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