Acute kidney injury in infants with hypoxic-ischemic encephalopathy
Background This study aimed to investigate the prevalence of acute kidney injury (AKI) in infants with varying degrees of hypoxic-ischemic encephalopathy (HIE) and its associated outcomes, including mortality and length of stay (LOS). Methods The study used the National Inpatient Sample (NIS) datase...
Gespeichert in:
| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2024-04, Vol.39 (4), p.1271-1277 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1277 |
|---|---|
| container_issue | 4 |
| container_start_page | 1271 |
| container_title | Pediatric nephrology (Berlin, West) |
| container_volume | 39 |
| creator | Elgendy, Marwa M. Cortez, Josef Saker, Firas Acun, Ceyda Matar, Raed Bou Mohamed, Mohamed A. Aly, Hany |
| description | Background
This study aimed to investigate the prevalence of acute kidney injury (AKI) in infants with varying degrees of hypoxic-ischemic encephalopathy (HIE) and its associated outcomes, including mortality and length of stay (LOS).
Methods
The study used the National Inpatient Sample (NIS) dataset from 2010 to 2018. Regression analysis was used to control confounding variables.
Results
Of 31,220,784 infants included in the study, 30,130 (0.1%) had HIE. The prevalence of AKI was significantly higher in infants with HIE (9.0%) compared to those without (0.04%), with an adjusted odds ratio (aOR) of 77.6 (CI:70.1–85.7,
p
|
| doi_str_mv | 10.1007/s00467-023-06214-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2889244208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2889244208</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-b0fcd4ae9870b475afc86628614a27634aa933c42239927f30983e586800a2603</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWqt_wIMsePESnWRiPo5S_IKCF4XeQppm3a3t7rrZRfvvTW1V8CAE5pBn3nl5CDlhcMEA1GUEEFJR4EhBciYo7pABE8gpM3qySwZgkFEQbHJADmOcA4C-0nKfHKAyQmljBmR07fsuZK_lrAqrrKzmfbse6eWu6mL2XnZFVqya-qP0tIy-CMvSZ6HyoSncom5cV6yOyF7uFjEcb-eQPN_ePI3u6fjx7mF0PaYeuezoFHI_Ey4YrWAq1JXLvZaSa8mE40qicM4gesE5GsNVjmA0hlRYAzguAYfkfJPbtPVbH2Jnl6lRWCxcFeo-Wq614UJw0Ak9-4PO676tUjvLDXJhQCEmim8o39YxtiG3TVsuXbuyDOxasd0otkmx_VJs10un2-h-ugyzn5VvpwnADRDTV_US2t_b_8R-AusqhQQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2932490733</pqid></control><display><type>article</type><title>Acute kidney injury in infants with hypoxic-ischemic encephalopathy</title><source>SpringerLink Journals</source><creator>Elgendy, Marwa M. ; Cortez, Josef ; Saker, Firas ; Acun, Ceyda ; Matar, Raed Bou ; Mohamed, Mohamed A. ; Aly, Hany</creator><creatorcontrib>Elgendy, Marwa M. ; Cortez, Josef ; Saker, Firas ; Acun, Ceyda ; Matar, Raed Bou ; Mohamed, Mohamed A. ; Aly, Hany</creatorcontrib><description>Background
This study aimed to investigate the prevalence of acute kidney injury (AKI) in infants with varying degrees of hypoxic-ischemic encephalopathy (HIE) and its associated outcomes, including mortality and length of stay (LOS).
Methods
The study used the National Inpatient Sample (NIS) dataset from 2010 to 2018. Regression analysis was used to control confounding variables.
Results
Of 31,220,784 infants included in the study, 30,130 (0.1%) had HIE. The prevalence of AKI was significantly higher in infants with HIE (9.0%) compared to those without (0.04%), with an adjusted odds ratio (aOR) of 77.6 (CI:70.1–85.7,
p
< 0.001), with the highest prevalence of AKI in infants with severe HIE (19.7%), aOR:130 (CI: 107–159),
p
< 0.001). Infants with AKI had a higher mortality rate compared to those without AKI in those diagnosed with any degree of HIE (28.9% vs. 8.8%), aOR 3.5 (CI: 3.2–3.9,
p
< 0.001), particularly among those with severe HIE, aOR:1.4 (1.2–1.6,
p
< 0.001).
Conclusions
HIE is associated with an increased prevalence of AKI. Infants with severe HIE had the highest prevalence of AKI and associated mortality. The study highlights the need for close monitoring and early detection of AKI in infants with HIE, particularly those with severe HIE, to ameliorate the associated adverse outcomes.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-023-06214-3</identifier><identifier>PMID: 37947899</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Brain damage ; Encephalopathy ; Hypoxia ; Infants ; Ischemia ; Kidneys ; Medicine ; Medicine & Public Health ; Mortality ; Nephrology ; Original Article ; Pediatrics ; Urology ; What’s new in AKI</subject><ispartof>Pediatric nephrology (Berlin, West), 2024-04, Vol.39 (4), p.1271-1277</ispartof><rights>The Author(s), under exclusive licence to International Pediatric Nephrology Association 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to International Pediatric Nephrology Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-b0fcd4ae9870b475afc86628614a27634aa933c42239927f30983e586800a2603</cites><orcidid>0000-0002-2361-983X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-023-06214-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-023-06214-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37947899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elgendy, Marwa M.</creatorcontrib><creatorcontrib>Cortez, Josef</creatorcontrib><creatorcontrib>Saker, Firas</creatorcontrib><creatorcontrib>Acun, Ceyda</creatorcontrib><creatorcontrib>Matar, Raed Bou</creatorcontrib><creatorcontrib>Mohamed, Mohamed A.</creatorcontrib><creatorcontrib>Aly, Hany</creatorcontrib><title>Acute kidney injury in infants with hypoxic-ischemic encephalopathy</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
This study aimed to investigate the prevalence of acute kidney injury (AKI) in infants with varying degrees of hypoxic-ischemic encephalopathy (HIE) and its associated outcomes, including mortality and length of stay (LOS).
Methods
The study used the National Inpatient Sample (NIS) dataset from 2010 to 2018. Regression analysis was used to control confounding variables.
Results
Of 31,220,784 infants included in the study, 30,130 (0.1%) had HIE. The prevalence of AKI was significantly higher in infants with HIE (9.0%) compared to those without (0.04%), with an adjusted odds ratio (aOR) of 77.6 (CI:70.1–85.7,
p
< 0.001), with the highest prevalence of AKI in infants with severe HIE (19.7%), aOR:130 (CI: 107–159),
p
< 0.001). Infants with AKI had a higher mortality rate compared to those without AKI in those diagnosed with any degree of HIE (28.9% vs. 8.8%), aOR 3.5 (CI: 3.2–3.9,
p
< 0.001), particularly among those with severe HIE, aOR:1.4 (1.2–1.6,
p
< 0.001).
Conclusions
HIE is associated with an increased prevalence of AKI. Infants with severe HIE had the highest prevalence of AKI and associated mortality. The study highlights the need for close monitoring and early detection of AKI in infants with HIE, particularly those with severe HIE, to ameliorate the associated adverse outcomes.</description><subject>Brain damage</subject><subject>Encephalopathy</subject><subject>Hypoxia</subject><subject>Infants</subject><subject>Ischemia</subject><subject>Kidneys</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Urology</subject><subject>What’s new in AKI</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWqt_wIMsePESnWRiPo5S_IKCF4XeQppm3a3t7rrZRfvvTW1V8CAE5pBn3nl5CDlhcMEA1GUEEFJR4EhBciYo7pABE8gpM3qySwZgkFEQbHJADmOcA4C-0nKfHKAyQmljBmR07fsuZK_lrAqrrKzmfbse6eWu6mL2XnZFVqya-qP0tIy-CMvSZ6HyoSncom5cV6yOyF7uFjEcb-eQPN_ePI3u6fjx7mF0PaYeuezoFHI_Ey4YrWAq1JXLvZaSa8mE40qicM4gesE5GsNVjmA0hlRYAzguAYfkfJPbtPVbH2Jnl6lRWCxcFeo-Wq614UJw0Ak9-4PO676tUjvLDXJhQCEmim8o39YxtiG3TVsuXbuyDOxasd0otkmx_VJs10un2-h-ugyzn5VvpwnADRDTV_US2t_b_8R-AusqhQQ</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Elgendy, Marwa M.</creator><creator>Cortez, Josef</creator><creator>Saker, Firas</creator><creator>Acun, Ceyda</creator><creator>Matar, Raed Bou</creator><creator>Mohamed, Mohamed A.</creator><creator>Aly, Hany</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2361-983X</orcidid></search><sort><creationdate>20240401</creationdate><title>Acute kidney injury in infants with hypoxic-ischemic encephalopathy</title><author>Elgendy, Marwa M. ; Cortez, Josef ; Saker, Firas ; Acun, Ceyda ; Matar, Raed Bou ; Mohamed, Mohamed A. ; Aly, Hany</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-b0fcd4ae9870b475afc86628614a27634aa933c42239927f30983e586800a2603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Brain damage</topic><topic>Encephalopathy</topic><topic>Hypoxia</topic><topic>Infants</topic><topic>Ischemia</topic><topic>Kidneys</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Urology</topic><topic>What’s new in AKI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elgendy, Marwa M.</creatorcontrib><creatorcontrib>Cortez, Josef</creatorcontrib><creatorcontrib>Saker, Firas</creatorcontrib><creatorcontrib>Acun, Ceyda</creatorcontrib><creatorcontrib>Matar, Raed Bou</creatorcontrib><creatorcontrib>Mohamed, Mohamed A.</creatorcontrib><creatorcontrib>Aly, Hany</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elgendy, Marwa M.</au><au>Cortez, Josef</au><au>Saker, Firas</au><au>Acun, Ceyda</au><au>Matar, Raed Bou</au><au>Mohamed, Mohamed A.</au><au>Aly, Hany</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute kidney injury in infants with hypoxic-ischemic encephalopathy</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>39</volume><issue>4</issue><spage>1271</spage><epage>1277</epage><pages>1271-1277</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Background
This study aimed to investigate the prevalence of acute kidney injury (AKI) in infants with varying degrees of hypoxic-ischemic encephalopathy (HIE) and its associated outcomes, including mortality and length of stay (LOS).
Methods
The study used the National Inpatient Sample (NIS) dataset from 2010 to 2018. Regression analysis was used to control confounding variables.
Results
Of 31,220,784 infants included in the study, 30,130 (0.1%) had HIE. The prevalence of AKI was significantly higher in infants with HIE (9.0%) compared to those without (0.04%), with an adjusted odds ratio (aOR) of 77.6 (CI:70.1–85.7,
p
< 0.001), with the highest prevalence of AKI in infants with severe HIE (19.7%), aOR:130 (CI: 107–159),
p
< 0.001). Infants with AKI had a higher mortality rate compared to those without AKI in those diagnosed with any degree of HIE (28.9% vs. 8.8%), aOR 3.5 (CI: 3.2–3.9,
p
< 0.001), particularly among those with severe HIE, aOR:1.4 (1.2–1.6,
p
< 0.001).
Conclusions
HIE is associated with an increased prevalence of AKI. Infants with severe HIE had the highest prevalence of AKI and associated mortality. The study highlights the need for close monitoring and early detection of AKI in infants with HIE, particularly those with severe HIE, to ameliorate the associated adverse outcomes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37947899</pmid><doi>10.1007/s00467-023-06214-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2361-983X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 2024-04, Vol.39 (4), p.1271-1277 |
| issn | 0931-041X 1432-198X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2889244208 |
| source | SpringerLink Journals |
| subjects | Brain damage Encephalopathy Hypoxia Infants Ischemia Kidneys Medicine Medicine & Public Health Mortality Nephrology Original Article Pediatrics Urology What’s new in AKI |
| title | Acute kidney injury in infants with hypoxic-ischemic encephalopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T09%3A56%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20kidney%20injury%20in%20infants%20with%20hypoxic-ischemic%20encephalopathy&rft.jtitle=Pediatric%20nephrology%20(Berlin,%20West)&rft.au=Elgendy,%20Marwa%20M.&rft.date=2024-04-01&rft.volume=39&rft.issue=4&rft.spage=1271&rft.epage=1277&rft.pages=1271-1277&rft.issn=0931-041X&rft.eissn=1432-198X&rft_id=info:doi/10.1007/s00467-023-06214-3&rft_dat=%3Cproquest_cross%3E2889244208%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2932490733&rft_id=info:pmid/37947899&rfr_iscdi=true |