O-GlcNAcylation of melanophilin enhances radiation resistance in glioblastoma via suppressing TRIM21 mediated ubiquitination

The molecular mechanism of glioblastoma (GBM) radiation resistance remains poorly understood. The aim of this study was to elucidate the potential role of Melanophilin (MLPH) O-GlcNAcylation and the specific mechanism through which it regulates GBM radiotherapy resistance. We found that MLPH was sig...

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Veröffentlicht in:	Oncogene 2024-01, Vol.43 (1), p.61-75
Hauptverfasser:	Xu, Lei, Ye, Yangfan, Tao, Zeqiang, Wang, Tian, Wei, Yutian, Cai, Wanzhi, Wan, Xin, Zhao, Pengzhan, Gu, Wei, Gu, Bin, Zhang, Liuchao, Tian, Yufei, Liu, Ning, Tu, Yiming, Ji, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 13/1 13/2 13/31 13/51 38/5 42/109 59/5 631/337/1427/2122 631/337/458/1524 631/67/1922 631/67/2327 631/67/68 64/114 82/80 Apoptosis Brain cancer Cell Biology Cell Line, Tumor Glioblastoma Glioblastoma - genetics Glioblastoma - pathology Glioblastoma - radiotherapy Human Genetics Humans Internal Medicine Ionizing radiation Medicine Medicine & Public Health Molecular modelling Neoplasm Recurrence, Local NF-kappa B - genetics NF-κB protein O-GlcNAcylation Oncology Radiation therapy Signal transduction Ubiquitin-protein ligase Ubiquitination
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