Progressive multifocal leukoencephalopathy in patients with chronic kidney disease
Progressive multifocal leukoencephalopathy (PML) is an opportunistic central nervous system infection caused by the human polyomavirus 2, leading to demyelination from oligodendrocyte death and rapid neurologic decline. Most commonly, PML affects patients in immunocompromised states. However, rare r...
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| Veröffentlicht in: | Neurological sciences 2024-04, Vol.45 (4), p.1619-1624 |
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| container_title | Neurological sciences |
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| creator | Meylor, Jennifer Artunduaga, Daniel Crespo Mendoza, Michael Hooshmand, Sam I. Obeidat, Ahmed Z. |
| description | Progressive multifocal leukoencephalopathy (PML) is an opportunistic central nervous system infection caused by the human polyomavirus 2, leading to demyelination from oligodendrocyte death and rapid neurologic decline. Most commonly, PML affects patients in immunocompromised states. However, rare reports of PML in an immunocompetent host exist. Here, we report two cases of PML in older individuals with chronic kidney disease (CKD). CKD can ultimately lead to immune system dysfunction and place patients in a relatively immunosuppressed state. Testing for JC virus should remain a consideration for rapid, unexplained neurologic decline even without known immunocompromised status in the appropriate clinical setting. |
| doi_str_mv | 10.1007/s10072-023-07182-0 |
| format | Article |
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Most commonly, PML affects patients in immunocompromised states. However, rare reports of PML in an immunocompetent host exist. Here, we report two cases of PML in older individuals with chronic kidney disease (CKD). CKD can ultimately lead to immune system dysfunction and place patients in a relatively immunosuppressed state. Testing for JC virus should remain a consideration for rapid, unexplained neurologic decline even without known immunocompromised status in the appropriate clinical setting.</description><identifier>ISSN: 1590-1874</identifier><identifier>EISSN: 1590-3478</identifier><identifier>DOI: 10.1007/s10072-023-07182-0</identifier><identifier>PMID: 37950135</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Cardiac arrhythmia ; Cardiovascular disease ; Cellular biology ; Central nervous system ; Comorbidity ; COVID-19 ; Demyelination ; HIV ; Hospice care ; Human immunodeficiency virus ; Immune system ; Immunocompetence ; Infections ; Kidney diseases ; Laboratories ; Leukoencephalopathy ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Nervous system ; Neurology ; Neuroradiology ; Neurosurgery ; Original Article ; Patients ; Progressive multifocal leukoencephalopathy ; Psychiatry ; Risk factors</subject><ispartof>Neurological sciences, 2024-04, Vol.45 (4), p.1619-1624</ispartof><rights>Fondazione Società Italiana di Neurologia 2023. 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| subjects | Acquired immune deficiency syndrome AIDS Cardiac arrhythmia Cardiovascular disease Cellular biology Central nervous system Comorbidity COVID-19 Demyelination HIV Hospice care Human immunodeficiency virus Immune system Immunocompetence Infections Kidney diseases Laboratories Leukoencephalopathy Medicine Medicine & Public Health Multiple sclerosis Nervous system Neurology Neuroradiology Neurosurgery Original Article Patients Progressive multifocal leukoencephalopathy Psychiatry Risk factors |
| title | Progressive multifocal leukoencephalopathy in patients with chronic kidney disease |
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