Inhibition of miR‐578 through SOCS2‐dependent manner reverses gefitinib resistance in NSCLC cells

Background Nonsmall‐cell lung cancer (NSCLC) has emerged as one of the dreadful lung cancers globally due to its increased mortality rates. Concerning chemotherapy, gefitinib has been employed as an effective first‐line treatment drug for NSCLC. Nonetheless, the acquired resistance to gefitinib has...

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Veröffentlicht in:	Environmental toxicology 2024-03, Vol.39 (3), p.1283-1293
Hauptverfasser:	Yang, Bo, Yao, Lei, Yang, Liankai, Zhao, Fang, Zhou, Wenyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell lines Cells Chemotherapy Gefitinib Gefitinib resistance Inhibitor drugs Lung cancer miRNA miR‐578 Non-small cell lung carcinoma NSCLC Nucleic acids Nucleotide sequence Polymerase chain reaction Reverse transcription Ribose SOCS2 Targeted cancer therapy Therapeutic targets Transcription Western blotting Xenotransplantation
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