Asymmetric Synthesis of Cyclopamine, a Hedgehog (Hh) Signaling Pathway Inhibitor

Cyclopamine is a teratogenic steroidal alkaloid, which inhibits the Hedgehog (Hh) signaling pathway by targeting the Smoothened (Smo) receptor. Suppression of Hh signaling with synthetic small molecules has been pursued as a therapeutic approach for the treatment of cancer. We report herein the asym...

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Veröffentlicht in:	Journal of the American Chemical Society 2023-11, Vol.145 (46), p.25086-25092
Hauptverfasser:	Shao, Hao, Liu, Wenheng, Liu, Muhan, He, Haibing, Zhou, Qi-Lin, Zhu, Shou-Fei, Gao, Shuanhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Antineoplastic Agents - pharmacology Hedgehog Proteins - metabolism Receptors, G-Protein-Coupled - metabolism Signal Transduction
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