Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma

•Aqueous fraction of ethanolic extract of Bacopa monnieri (BM-AF) was found to have potent anticancer potential against oral cancer cells.•BM-AF induced Parkin dependent mitophagy in oral cancer cells.•BM-AF inhibited arecoline-induced NLRP3 inflammasome activation in both in-vitro and in-vivo oral...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-01, Vol.123, p.155157-155157, Article 155157
Hauptverfasser:	Mishra, Soumya Ranjan, Behera, Bishnu Prasad, Singh, Vineet Kumar, Mahapatra, Kewal Kumar, Mundkinajeddu, Deepak, Bhat, Deeksha, Minz, Aruna Mukti, Sethi, Gautam, Efferth, Thomas, Das, Surajit, Bhutia, Sujit Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Arecoline - pharmacology Bacopa - metabolism Bacopa monnieri Carcinoma, Squamous Cell - drug therapy Head and Neck Neoplasms Humans Inflammasomes - metabolism Mice Mice, Inbred C57BL Mitophagy Mouth Neoplasms - drug therapy NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Oral cancer Reactive Oxygen Species - metabolism Squamous Cell Carcinoma of Head and Neck
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