Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis
Background and objective A correlation between neutrophil extracellular traps (NETs) and ischemic stroke (IS) has been hypothesized, but the results of relevant studies remain controversial. The purpose was to determine whether NETs have an impact on ischemic stroke. Methods The studies on the corre...
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| Veröffentlicht in: | Acta neurologica Belgica 2024-04, Vol.124 (2), p.513-522 |
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| creator | Wu, Zhuo-Rao Zhou, Tian-Qi Ai, Shuang-Chun |
| description | Background and objective
A correlation between neutrophil extracellular traps (NETs) and ischemic stroke (IS) has been hypothesized, but the results of relevant studies remain controversial. The purpose was to determine whether NETs have an impact on ischemic stroke.
Methods
The studies on the correlation between NETs and IS were retrieved from CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science, Embase, and Cochrane databases by computer from the start of the database to December 2022. The study adhered to PRISMA guidelines. The PICOS model was used to create inclusion criteria. Two researchers screened the literature and extracted the relevant data. The quality of the included studies was evaluated using the NOS and the 11 items recommended by the AHRQ, and meta-analysis was completed using Stata 15.1 software.
Results
The researchers included 752 patients in 7 studies (4 case–control studies and 3 cross-sectional studies). The meta-analysis found NETs are positively associated with the severity of IS at the time of onset [r(95% CI) = 0.31(0.24, 0.38),
P
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| doi_str_mv | 10.1007/s13760-023-02409-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2889241017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2889241017</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-61d9991007a023f43143e5e12cca1a2ae3dcc4e36354e7ccfb2bc9a5101540033</originalsourceid><addsrcrecordid>eNp9kctuFDEQRS0EIqOQH8gCecmmiV_dPWaHIgJIEWyStVXjqck49AuXO8n8Ax-dSjqwxJLlknzqqu4tIU61-qiVas9I27ZRlTKWr1O-ql-JleGqMt7b12KlrFKVV8ofiROiW8XHNUa3zVtxZFtfq7WpV-LPD5xLHqd96iQ-lAwRu27uIEuuJ5JxzBk7KCjvU9lLwjvMqRwkDFs55fFmGCmRTIOcoCQcCi1corjHPkVJLP4LP0mQdKCCPVNRZrxLeP-s0WOBCgboDqzzTrzZQUd48vIei-uLL1fn36rLn1-_n3--rKJ1bakavfXeP6UAbH_nrHYWa9QmRtBgAO02Roe2sbXDNsbdxmyih1orXTulrD0WHxZddvB7Riqh54HZOAw4zhTMeu2NY7xl1CxozCNRxl2YcuohH4JW4WmEsCwi8CTheRGh5qb3L_rzpsftv5a_sTNgF4D4a7jBHG7HOXMK9D_ZR0Bklp0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2889241017</pqid></control><display><type>article</type><title>Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis</title><source>SpringerLink Journals</source><creator>Wu, Zhuo-Rao ; Zhou, Tian-Qi ; Ai, Shuang-Chun</creator><creatorcontrib>Wu, Zhuo-Rao ; Zhou, Tian-Qi ; Ai, Shuang-Chun</creatorcontrib><description>Background and objective
A correlation between neutrophil extracellular traps (NETs) and ischemic stroke (IS) has been hypothesized, but the results of relevant studies remain controversial. The purpose was to determine whether NETs have an impact on ischemic stroke.
Methods
The studies on the correlation between NETs and IS were retrieved from CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science, Embase, and Cochrane databases by computer from the start of the database to December 2022. The study adhered to PRISMA guidelines. The PICOS model was used to create inclusion criteria. Two researchers screened the literature and extracted the relevant data. The quality of the included studies was evaluated using the NOS and the 11 items recommended by the AHRQ, and meta-analysis was completed using Stata 15.1 software.
Results
The researchers included 752 patients in 7 studies (4 case–control studies and 3 cross-sectional studies). The meta-analysis found NETs are positively associated with the severity of IS at the time of onset [r(95% CI) = 0.31(0.24, 0.38),
P
< 0.001]. NETs are positively associated with a worse prognosis of IS [r(95% CI) = 0.34(0.13, 0.53),
P
= 0.003].
Conclusion
The presence of NETs is positively related to the severity and prognosis of IS. Higher levels of NETs indicate a more severe disease and a poorer prognosis. Because the number and quality of included studies are limited, the above results must be supported by further high-quality studies.
Systematic review registration:
https://www.crd.york.ac.uk/PROSPERO/
, identifier: CRD42022356619.</description><identifier>ISSN: 0300-9009</identifier><identifier>ISSN: 2240-2993</identifier><identifier>EISSN: 2240-2993</identifier><identifier>DOI: 10.1007/s13760-023-02409-5</identifier><identifier>PMID: 37950825</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; CRD ; CRD42022356619 ; Medicine/Public Health ; Neurology ; Neuroradiology ; Neurosciences ; Original Article</subject><ispartof>Acta neurologica Belgica, 2024-04, Vol.124 (2), p.513-522</ispartof><rights>The Author(s) under exclusive licence to Belgian Neurological Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s) under exclusive licence to Belgian Neurological Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-61d9991007a023f43143e5e12cca1a2ae3dcc4e36354e7ccfb2bc9a5101540033</citedby><cites>FETCH-LOGICAL-c347t-61d9991007a023f43143e5e12cca1a2ae3dcc4e36354e7ccfb2bc9a5101540033</cites><orcidid>0000-0002-3946-3008 ; 0000-0002-9318-099X ; 0000-0001-6801-4589</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13760-023-02409-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13760-023-02409-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37950825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Zhuo-Rao</creatorcontrib><creatorcontrib>Zhou, Tian-Qi</creatorcontrib><creatorcontrib>Ai, Shuang-Chun</creatorcontrib><title>Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis</title><title>Acta neurologica Belgica</title><addtitle>Acta Neurol Belg</addtitle><addtitle>Acta Neurol Belg</addtitle><description>Background and objective
A correlation between neutrophil extracellular traps (NETs) and ischemic stroke (IS) has been hypothesized, but the results of relevant studies remain controversial. The purpose was to determine whether NETs have an impact on ischemic stroke.
Methods
The studies on the correlation between NETs and IS were retrieved from CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science, Embase, and Cochrane databases by computer from the start of the database to December 2022. The study adhered to PRISMA guidelines. The PICOS model was used to create inclusion criteria. Two researchers screened the literature and extracted the relevant data. The quality of the included studies was evaluated using the NOS and the 11 items recommended by the AHRQ, and meta-analysis was completed using Stata 15.1 software.
Results
The researchers included 752 patients in 7 studies (4 case–control studies and 3 cross-sectional studies). The meta-analysis found NETs are positively associated with the severity of IS at the time of onset [r(95% CI) = 0.31(0.24, 0.38),
P
< 0.001]. NETs are positively associated with a worse prognosis of IS [r(95% CI) = 0.34(0.13, 0.53),
P
= 0.003].
Conclusion
The presence of NETs is positively related to the severity and prognosis of IS. Higher levels of NETs indicate a more severe disease and a poorer prognosis. Because the number and quality of included studies are limited, the above results must be supported by further high-quality studies.
Systematic review registration:
https://www.crd.york.ac.uk/PROSPERO/
, identifier: CRD42022356619.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CRD</subject><subject>CRD42022356619</subject><subject>Medicine/Public Health</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Article</subject><issn>0300-9009</issn><issn>2240-2993</issn><issn>2240-2993</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kctuFDEQRS0EIqOQH8gCecmmiV_dPWaHIgJIEWyStVXjqck49AuXO8n8Ax-dSjqwxJLlknzqqu4tIU61-qiVas9I27ZRlTKWr1O-ql-JleGqMt7b12KlrFKVV8ofiROiW8XHNUa3zVtxZFtfq7WpV-LPD5xLHqd96iQ-lAwRu27uIEuuJ5JxzBk7KCjvU9lLwjvMqRwkDFs55fFmGCmRTIOcoCQcCi1corjHPkVJLP4LP0mQdKCCPVNRZrxLeP-s0WOBCgboDqzzTrzZQUd48vIei-uLL1fn36rLn1-_n3--rKJ1bakavfXeP6UAbH_nrHYWa9QmRtBgAO02Roe2sbXDNsbdxmyih1orXTulrD0WHxZddvB7Riqh54HZOAw4zhTMeu2NY7xl1CxozCNRxl2YcuohH4JW4WmEsCwi8CTheRGh5qb3L_rzpsftv5a_sTNgF4D4a7jBHG7HOXMK9D_ZR0Bklp0</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Wu, Zhuo-Rao</creator><creator>Zhou, Tian-Qi</creator><creator>Ai, Shuang-Chun</creator><general>Springer International Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3946-3008</orcidid><orcidid>https://orcid.org/0000-0002-9318-099X</orcidid><orcidid>https://orcid.org/0000-0001-6801-4589</orcidid></search><sort><creationdate>20240401</creationdate><title>Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis</title><author>Wu, Zhuo-Rao ; Zhou, Tian-Qi ; Ai, Shuang-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-61d9991007a023f43143e5e12cca1a2ae3dcc4e36354e7ccfb2bc9a5101540033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CRD</topic><topic>CRD42022356619</topic><topic>Medicine/Public Health</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Zhuo-Rao</creatorcontrib><creatorcontrib>Zhou, Tian-Qi</creatorcontrib><creatorcontrib>Ai, Shuang-Chun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurologica Belgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Zhuo-Rao</au><au>Zhou, Tian-Qi</au><au>Ai, Shuang-Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis</atitle><jtitle>Acta neurologica Belgica</jtitle><stitle>Acta Neurol Belg</stitle><addtitle>Acta Neurol Belg</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>124</volume><issue>2</issue><spage>513</spage><epage>522</epage><pages>513-522</pages><issn>0300-9009</issn><issn>2240-2993</issn><eissn>2240-2993</eissn><abstract>Background and objective
A correlation between neutrophil extracellular traps (NETs) and ischemic stroke (IS) has been hypothesized, but the results of relevant studies remain controversial. The purpose was to determine whether NETs have an impact on ischemic stroke.
Methods
The studies on the correlation between NETs and IS were retrieved from CNKI, Wanfang Data, VIP, CBM, PubMed, Web of Science, Embase, and Cochrane databases by computer from the start of the database to December 2022. The study adhered to PRISMA guidelines. The PICOS model was used to create inclusion criteria. Two researchers screened the literature and extracted the relevant data. The quality of the included studies was evaluated using the NOS and the 11 items recommended by the AHRQ, and meta-analysis was completed using Stata 15.1 software.
Results
The researchers included 752 patients in 7 studies (4 case–control studies and 3 cross-sectional studies). The meta-analysis found NETs are positively associated with the severity of IS at the time of onset [r(95% CI) = 0.31(0.24, 0.38),
P
< 0.001]. NETs are positively associated with a worse prognosis of IS [r(95% CI) = 0.34(0.13, 0.53),
P
= 0.003].
Conclusion
The presence of NETs is positively related to the severity and prognosis of IS. Higher levels of NETs indicate a more severe disease and a poorer prognosis. Because the number and quality of included studies are limited, the above results must be supported by further high-quality studies.
Systematic review registration:
https://www.crd.york.ac.uk/PROSPERO/
, identifier: CRD42022356619.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37950825</pmid><doi>10.1007/s13760-023-02409-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3946-3008</orcidid><orcidid>https://orcid.org/0000-0002-9318-099X</orcidid><orcidid>https://orcid.org/0000-0001-6801-4589</orcidid></addata></record> |
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| title | Neutrophil extracellular traps correlate with severity and prognosis in patients with ischemic stroke: a systematic review and meta-analysis |
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