O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins

N 6 -methyladenosine (m 6 A) is the most abundant internal mRNA nucleotide modification in mammals, regulating critical aspects of cell physiology and differentiation. The YTHDF proteins are the primary readers of m 6 A modifications and exert physiological functions of m 6 A in the cytosol. Elucida...

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Veröffentlicht in:	Nature cell biology 2023-11, Vol.25 (11), p.1676-1690
Hauptverfasser:	Chen, Yulin, Wan, Ruixi, Zou, Zhongyu, Lao, Lihui, Shao, Guojian, Zheng, Yingying, Tang, Ling, Yuan, Ying, Ge, Yun, He, Chuan, Lin, Shixian
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 14/19 38/89 45/29 45/91 631/208/514 631/337/574 631/45/500 631/80/458/1524 631/80/86/2366 82/51 82/58 82/80 82/83 Animals Biomedical and Life Sciences Cancer Research Cell Biology Cell differentiation Cytosol Developmental Biology Gene Expression Regulation Gene regulation Life Sciences Mammals - metabolism N6-methyladenosine Nucleotides O-GlcNAcylation Phase separation Physiology Post-transcription Post-translation Protein Processing, Post-Translational Proteins Proteins - metabolism Regulatory mechanisms (biology) RNA modification RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding protein Stem Cells Translation
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