Targeting PKD2 aggravates ferritinophagy-mediated ferroptosis via promoting autophagosome-lysosome fusion and enhances efficacy of carboplatin in lung adenocarcinoma

Ferroptosis is an iron-dependent cell death and affects efficacies of multiple antitumor regimens, showing a great potential in cancer therapy. Protein kinase D2 (PKD2) plays a crucial role in regulating necrosis and apoptosis. However, the relationship of PKD2 and ferroptosis is still elusive. In t...

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Veröffentlicht in:	Chemico-biological interactions 2024-01, Vol.387, p.110794-110794, Article 110794
Hauptverfasser:	Liu, Yong, Pang, Zhaofei, Wang, Yadong, Liu, Jichang, Wang, Guanghui, Du, Jiajun
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Ferroptosis Lung adenocarcinoma Protein kinase D2 Reactive oxygen species
Online-Zugang:	Volltext
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