Neutrophil-to-lymphocyte ratio is independently associated with carotid atherosclerosis burden in individuals with type 1 diabetes
Recent studies have identified a relationship between innate versus. Adaptative immunity and cardiovascular disease (CVD) in the general population, but information on type 1 diabetes (T1D) is lacking. We aimed to study the relationship between inflammatory biomarkers and preclinical atherosclerosis...
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| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2024-02, Vol.34 (2), p.395-403 |
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| creator | Mariaca, Karla Serés-Noriega, Tonet Viñals, Clara Perea, Verónica Conget, Ignacio Mesa, Alex Boswell, Laura Font, Carla Pané, Adriana Vinagre, Irene Blanco, Jesús Esmatjes, Enric Giménez, Marga Amor, Antonio J. |
| description | Recent studies have identified a relationship between innate versus. Adaptative immunity and cardiovascular disease (CVD) in the general population, but information on type 1 diabetes (T1D) is lacking. We aimed to study the relationship between inflammatory biomarkers and preclinical atherosclerosis in this population.
Cross-sectional study in T1D individuals without CVD and with ≥1 of the following: ≥40 years, diabetic kidney disease, or ≥10 years of diabetes duration with classical CVD risk factors. Carotid plaques were evaluated by ultrasonography. C-reactive protein, total leukocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio and systemic immune-inflammation index were assessed as inflammatory markers. Multivariate-adjusted models including age, sex, and other CVD risk factors were constructed to test their independent associations with atherosclerosis burden. We included 602 subjects (52.8% men, 48.7 ± 10.2 years old and 27.0 ± 10.5 years of diabetes duration). Carotid plaques were found in 41.2% of the individuals (12.8%, ≥3 plaques). The number of carotid plaques (none, 1–2, ≥3 plaques), was directly associated with the leukocyte count (6570 [5445–8050], 6640 [5450–8470] and 7310 [5715–8935] per mm3, respectively; p for trend = 0.021) and the NLR (1.63 [1.28–2.13], 1.78 [1.38–2.25] and 2.14 [1.58–2.92], respectively; p for trend |
| doi_str_mv | 10.1016/j.numecd.2023.09.017 |
| format | Article |
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Cross-sectional study in T1D individuals without CVD and with ≥1 of the following: ≥40 years, diabetic kidney disease, or ≥10 years of diabetes duration with classical CVD risk factors. Carotid plaques were evaluated by ultrasonography. C-reactive protein, total leukocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio and systemic immune-inflammation index were assessed as inflammatory markers. Multivariate-adjusted models including age, sex, and other CVD risk factors were constructed to test their independent associations with atherosclerosis burden. We included 602 subjects (52.8% men, 48.7 ± 10.2 years old and 27.0 ± 10.5 years of diabetes duration). Carotid plaques were found in 41.2% of the individuals (12.8%, ≥3 plaques). The number of carotid plaques (none, 1–2, ≥3 plaques), was directly associated with the leukocyte count (6570 [5445–8050], 6640 [5450–8470] and 7310 [5715–8935] per mm3, respectively; p for trend = 0.021) and the NLR (1.63 [1.28–2.13], 1.78 [1.38–2.25] and 2.14 [1.58–2.92], respectively; p for trend <0.001), but only the NLR remained directly associated in fully-adjusted models (presence of plaques; OR 1.285 [1.040–1.587]; ≥3 plaques, OR 1.377 [1.036–1.829]).
The NLR was independently and directly associated with carotid plaque burden in T1D individuals. Our data support the role of innate versus. Adaptative immunity in atherosclerosis also among the T1D population.
[Display omitted]
•The role of inflammation in atherosclerosis progression in T1D is poorly understood.•Neutrophil-to-lymphocyte ratio shows the balance between innate/adaptative immunity.•This ratio (NLR) was independently associated with carotid atherosclerosis in T1D.•NLR was not only associated with presence, but the number of carotid plaques.•These associations were independent of other classical or T1D-specific risk factors.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2023.09.017</identifier><identifier>PMID: 37951756</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Atherosclerosis ; biomarkers ; C-reactive protein ; Carotid Artery Diseases - epidemiology ; Carotid ultrasonography ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - diagnosis ; Female ; Humans ; immunity ; Inflammation ; insulin-dependent diabetes mellitus ; kidney diseases ; leukocyte count ; Lymphocytes ; Male ; metabolism ; Middle Aged ; Neutrophil-to-lymphocyte ratio ; Neutrophils ; nutrition ; Plaque, Atherosclerotic ; Preclinical atherosclerosis ; risk ; Type 1 diabetes ; ultrasonography</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2024-02, Vol.34 (2), p.395-403</ispartof><rights>2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-218c6d228ac6a77ad856c2041412f6b9edd9f39ee0af3d310fc9d4cfe4ecdad83</citedby><cites>FETCH-LOGICAL-c395t-218c6d228ac6a77ad856c2041412f6b9edd9f39ee0af3d310fc9d4cfe4ecdad83</cites><orcidid>0000-0001-8104-7326 ; 0000-0003-0696-2529 ; 0000-0001-9237-0903 ; 0000-0003-4974-0969 ; 0000-0002-7810-1827 ; 0000-0001-6459-5566 ; 0000-0002-6888-0396 ; 0000-0001-8760-3370 ; 0000-0002-8553-4030 ; 0000-0003-2976-1690</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0939475323003782$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37951756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mariaca, Karla</creatorcontrib><creatorcontrib>Serés-Noriega, Tonet</creatorcontrib><creatorcontrib>Viñals, Clara</creatorcontrib><creatorcontrib>Perea, Verónica</creatorcontrib><creatorcontrib>Conget, Ignacio</creatorcontrib><creatorcontrib>Mesa, Alex</creatorcontrib><creatorcontrib>Boswell, Laura</creatorcontrib><creatorcontrib>Font, Carla</creatorcontrib><creatorcontrib>Pané, Adriana</creatorcontrib><creatorcontrib>Vinagre, Irene</creatorcontrib><creatorcontrib>Blanco, Jesús</creatorcontrib><creatorcontrib>Esmatjes, Enric</creatorcontrib><creatorcontrib>Giménez, Marga</creatorcontrib><creatorcontrib>Amor, Antonio J.</creatorcontrib><title>Neutrophil-to-lymphocyte ratio is independently associated with carotid atherosclerosis burden in individuals with type 1 diabetes</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Recent studies have identified a relationship between innate versus. Adaptative immunity and cardiovascular disease (CVD) in the general population, but information on type 1 diabetes (T1D) is lacking. We aimed to study the relationship between inflammatory biomarkers and preclinical atherosclerosis in this population.
Cross-sectional study in T1D individuals without CVD and with ≥1 of the following: ≥40 years, diabetic kidney disease, or ≥10 years of diabetes duration with classical CVD risk factors. Carotid plaques were evaluated by ultrasonography. C-reactive protein, total leukocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio and systemic immune-inflammation index were assessed as inflammatory markers. Multivariate-adjusted models including age, sex, and other CVD risk factors were constructed to test their independent associations with atherosclerosis burden. We included 602 subjects (52.8% men, 48.7 ± 10.2 years old and 27.0 ± 10.5 years of diabetes duration). Carotid plaques were found in 41.2% of the individuals (12.8%, ≥3 plaques). The number of carotid plaques (none, 1–2, ≥3 plaques), was directly associated with the leukocyte count (6570 [5445–8050], 6640 [5450–8470] and 7310 [5715–8935] per mm3, respectively; p for trend = 0.021) and the NLR (1.63 [1.28–2.13], 1.78 [1.38–2.25] and 2.14 [1.58–2.92], respectively; p for trend <0.001), but only the NLR remained directly associated in fully-adjusted models (presence of plaques; OR 1.285 [1.040–1.587]; ≥3 plaques, OR 1.377 [1.036–1.829]).
The NLR was independently and directly associated with carotid plaque burden in T1D individuals. Our data support the role of innate versus. Adaptative immunity in atherosclerosis also among the T1D population.
[Display omitted]
•The role of inflammation in atherosclerosis progression in T1D is poorly understood.•Neutrophil-to-lymphocyte ratio shows the balance between innate/adaptative immunity.•This ratio (NLR) was independently associated with carotid atherosclerosis in T1D.•NLR was not only associated with presence, but the number of carotid plaques.•These associations were independent of other classical or T1D-specific risk factors.</description><subject>Adult</subject><subject>Atherosclerosis</subject><subject>biomarkers</subject><subject>C-reactive protein</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid ultrasonography</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>immunity</subject><subject>Inflammation</subject><subject>insulin-dependent diabetes mellitus</subject><subject>kidney diseases</subject><subject>leukocyte count</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>metabolism</subject><subject>Middle Aged</subject><subject>Neutrophil-to-lymphocyte ratio</subject><subject>Neutrophils</subject><subject>nutrition</subject><subject>Plaque, Atherosclerotic</subject><subject>Preclinical atherosclerosis</subject><subject>risk</subject><subject>Type 1 diabetes</subject><subject>ultrasonography</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1URLeFf4CQj70k-CtxfKlUVUArVXCBs-W1J1qvkji1naJc-eV4lbZHuIwP8zwz8rwIfaSkpoS2n4_1tIxgXc0I4zVRNaHyDdrRRpGKS6bO0I4oriohG36OLlI6EsIl4eIdOudSNVQ27Q79-Q5LjmE--KHKoRrWcT4Eu2bA0WQfsE_YTw5mKGXKw4pNSsF6k8Hh3z4fsDUxZO-wyQeIIdnhVIu1X2Ixinzy_ZN3ixnSpuR1Bkyx82YPGdJ79LYvPfjw_F6iX1-__Ly9qx5-fLu_vXmoLFdNrhjtbOsY64xtjZTGdU1rGRFUUNa3ewXOqZ4rAGJ67jglvVVO2B5EOVKh-SW62ubOMTwukLIefbIwDGaCsCTNacMbJTsm_ouyrlNMEMZIQcWG2vLvFKHXc_SjiaumRJ-C0ke9BaVPQWmidAmqaJ-eNyz7Edyr9JJMAa43AMpJnjxEnayHyYLzEWzWLvh_b_gLxpmqUA</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Mariaca, Karla</creator><creator>Serés-Noriega, Tonet</creator><creator>Viñals, Clara</creator><creator>Perea, Verónica</creator><creator>Conget, Ignacio</creator><creator>Mesa, Alex</creator><creator>Boswell, Laura</creator><creator>Font, Carla</creator><creator>Pané, Adriana</creator><creator>Vinagre, Irene</creator><creator>Blanco, Jesús</creator><creator>Esmatjes, Enric</creator><creator>Giménez, Marga</creator><creator>Amor, Antonio J.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-8104-7326</orcidid><orcidid>https://orcid.org/0000-0003-0696-2529</orcidid><orcidid>https://orcid.org/0000-0001-9237-0903</orcidid><orcidid>https://orcid.org/0000-0003-4974-0969</orcidid><orcidid>https://orcid.org/0000-0002-7810-1827</orcidid><orcidid>https://orcid.org/0000-0001-6459-5566</orcidid><orcidid>https://orcid.org/0000-0002-6888-0396</orcidid><orcidid>https://orcid.org/0000-0001-8760-3370</orcidid><orcidid>https://orcid.org/0000-0002-8553-4030</orcidid><orcidid>https://orcid.org/0000-0003-2976-1690</orcidid></search><sort><creationdate>20240201</creationdate><title>Neutrophil-to-lymphocyte ratio is independently associated with carotid atherosclerosis burden in individuals with type 1 diabetes</title><author>Mariaca, Karla ; 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Adaptative immunity and cardiovascular disease (CVD) in the general population, but information on type 1 diabetes (T1D) is lacking. We aimed to study the relationship between inflammatory biomarkers and preclinical atherosclerosis in this population.
Cross-sectional study in T1D individuals without CVD and with ≥1 of the following: ≥40 years, diabetic kidney disease, or ≥10 years of diabetes duration with classical CVD risk factors. Carotid plaques were evaluated by ultrasonography. C-reactive protein, total leukocyte count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio and systemic immune-inflammation index were assessed as inflammatory markers. Multivariate-adjusted models including age, sex, and other CVD risk factors were constructed to test their independent associations with atherosclerosis burden. We included 602 subjects (52.8% men, 48.7 ± 10.2 years old and 27.0 ± 10.5 years of diabetes duration). Carotid plaques were found in 41.2% of the individuals (12.8%, ≥3 plaques). The number of carotid plaques (none, 1–2, ≥3 plaques), was directly associated with the leukocyte count (6570 [5445–8050], 6640 [5450–8470] and 7310 [5715–8935] per mm3, respectively; p for trend = 0.021) and the NLR (1.63 [1.28–2.13], 1.78 [1.38–2.25] and 2.14 [1.58–2.92], respectively; p for trend <0.001), but only the NLR remained directly associated in fully-adjusted models (presence of plaques; OR 1.285 [1.040–1.587]; ≥3 plaques, OR 1.377 [1.036–1.829]).
The NLR was independently and directly associated with carotid plaque burden in T1D individuals. Our data support the role of innate versus. Adaptative immunity in atherosclerosis also among the T1D population.
[Display omitted]
•The role of inflammation in atherosclerosis progression in T1D is poorly understood.•Neutrophil-to-lymphocyte ratio shows the balance between innate/adaptative immunity.•This ratio (NLR) was independently associated with carotid atherosclerosis in T1D.•NLR was not only associated with presence, but the number of carotid plaques.•These associations were independent of other classical or T1D-specific risk factors.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37951756</pmid><doi>10.1016/j.numecd.2023.09.017</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8104-7326</orcidid><orcidid>https://orcid.org/0000-0003-0696-2529</orcidid><orcidid>https://orcid.org/0000-0001-9237-0903</orcidid><orcidid>https://orcid.org/0000-0003-4974-0969</orcidid><orcidid>https://orcid.org/0000-0002-7810-1827</orcidid><orcidid>https://orcid.org/0000-0001-6459-5566</orcidid><orcidid>https://orcid.org/0000-0002-6888-0396</orcidid><orcidid>https://orcid.org/0000-0001-8760-3370</orcidid><orcidid>https://orcid.org/0000-0002-8553-4030</orcidid><orcidid>https://orcid.org/0000-0003-2976-1690</orcidid></addata></record> |
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| ispartof | Nutrition, metabolism, and cardiovascular diseases, 2024-02, Vol.34 (2), p.395-403 |
| issn | 0939-4753 1590-3729 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Atherosclerosis biomarkers C-reactive protein Carotid Artery Diseases - epidemiology Carotid ultrasonography Cross-Sectional Studies Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - diagnosis Female Humans immunity Inflammation insulin-dependent diabetes mellitus kidney diseases leukocyte count Lymphocytes Male metabolism Middle Aged Neutrophil-to-lymphocyte ratio Neutrophils nutrition Plaque, Atherosclerotic Preclinical atherosclerosis risk Type 1 diabetes ultrasonography |
| title | Neutrophil-to-lymphocyte ratio is independently associated with carotid atherosclerosis burden in individuals with type 1 diabetes |
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