Nuclear Factor Erythroid 2-Related Factor 2 is Essential for Low-Normobaric Oxygen Treatment-Mediated Blood-Brain Barrier Protection Following Ischemic Stroke

Cerebral ischemia/reperfusion (I/R) injury increases blood-brain barrier (BBB) permeability, leading to hemorrhagic transformation and brain edema. Normobaric oxygen (NBO) is a routine clinical treatment strategy for this condition. However, its neuroprotective effects remain controversial. This stu...

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Veröffentlicht in:	Molecular neurobiology 2024-05, Vol.61 (5), p.2938-2948
Hauptverfasser:	Ma, Xiao-Xiao, Xie, Hai-Yi, Hou, Pin-Pin, Wang, Xiao-Jing, Zhou, Wei, Wang, Zhen-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain Edema - metabolism Brain Edema - pathology Brain injury Cell Biology Cerebral blood flow Edema Endoplasmic Reticulum Stress - drug effects Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Glucose - deficiency Glucose - metabolism Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - therapy Ischemia Ischemic Stroke - metabolism Ischemic Stroke - pathology Ischemic Stroke - therapy Male Membrane permeability Mice Mice, Inbred C57BL Microvasculature Neurobiology Neurology Neuroprotection Neuroprotective Agents - pharmacology Neurosciences NF-E2-Related Factor 2 - metabolism NRF2 protein Oxygen - metabolism Permeability Reactive oxygen species Reactive Oxygen Species - metabolism Reperfusion Reperfusion Injury - metabolism Reperfusion Injury - therapy
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