Simultaneous dendritic cells targeting and effective endosomal escape enhance sialic acid-modified mRNA vaccine efficacy and reduce side effects

mRNA vaccines are attractive prospects for the development of DC-targeted vaccines; however, no clinical success has been realized because, currently, it is difficult to simultaneously achieve DC targeting and efficient endosomal/lysosomal escape. Herein, we developed a sialic acid (SA)-modified mRN...

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Veröffentlicht in:	Journal of controlled release 2023-12, Vol.364, p.529-545
Hauptverfasser:	Tang, Xueying, Zhang, Jiashuo, Sui, Dezhi, Yang, Qiongfen, Wang, Tianyu, Xu, Zihan, Li, Xiaoya, Gao, Xin, Yan, Xinyang, Liu, Xinrong, Song, Yanzhi, Deng, Yihui
Format:	Artikel
Sprache:	eng
Schlagworte:	Dendritic Cells Endosomes mRNA Vaccines N-Acetylneuraminic Acid Nanoparticles RNA, Messenger - genetics Vaccine Efficacy
Online-Zugang:	Volltext
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