Increased Left Ventricular End-Diastolic Volume Index Is Associated With Increased Adverse Events After MitraClip Implantation
This study investigated the association between the left ventricular end-diastolic volume index (LVEDVI) and the incidence of adverse clinical events in patients after MitraClip implantation. In this retrospective, observational study, 123 patients who underwent the MitraClip procedure were enrolled...
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| Veröffentlicht in: | The American journal of cardiology 2024-01, Vol.211, p.106-111 |
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| container_title | The American journal of cardiology |
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| creator | Yoshikawa, Masafumi Arashi, Hiroyuki Kikuchi, Noriko Koyanagi-Saito, Chihiro Domoto, Satoru Niinami, Hiroshi Yamaguchi, Junichi |
| description | This study investigated the association between the left ventricular end-diastolic volume index (LVEDVI) and the incidence of adverse clinical events in patients after MitraClip implantation. In this retrospective, observational study, 123 patients who underwent the MitraClip procedure were enrolled. Participants were divided into 2 groups according to the LVEDVI cut-off level, calculated using receiver operating characteristic curve analysis, to predict the primary end point and the occurrence of cardiovascular events was compared between the groups. The primary end point was all-cause mortality and hospitalization because of heart failure. The receiver operating characteristic curve analysis for the composite primary end point revealed an LVEDVI cut-off point of 118 ml/m
. Based on this threshold, 61 patients (49.6%) were categorized into the LVEDVI |
| doi_str_mv | 10.1016/j.amjcard.2023.10.090 |
| format | Article |
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. Based on this threshold, 61 patients (49.6%) were categorized into the LVEDVI <118 ml/m
group, whereas 62 (50.4%) fell into the LVEDVI ≥118 ml/m
group. Over a median follow-up period of 336 days (interquartile range 80 to 667), the primary end points occurred in 15 and 26 patients in the LVEDVI <118 and LVEDVI ≥118 ml/m
groups, corresponding to incidence rates of 24.6% and 41.9%, respectively. Patients in the LVEDVI ≥118 ml/m
group demonstrated a significantly higher risk of adverse clinical events than those in the LVEDVI <118 ml/m
group (hazard ratio 2.24, 95% confidence interval 1.17 to 4.28, p = 0.01). This trend persisted even after adjusting for several confounders (p = 0.02). In conclusion, increased LVEDVI values were associated with increased adverse clinical events after MitraClip implantation in patients with severe mitral valve regurgitation.</description><identifier>ISSN: 0002-9149</identifier><identifier>ISSN: 1879-1913</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2023.10.090</identifier><identifier>PMID: 37949338</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Congestive heart failure ; Cut-off ; Ejection fraction ; Heart failure ; Heart Valve Prosthesis Implantation - methods ; Humans ; Implantation ; Mitral valve ; Mitral Valve Insufficiency ; Mortality ; Observational studies ; Patients ; Pulmonary arteries ; Regression analysis ; Regurgitation ; Retrospective Studies ; Stroke Volume ; Transplants & implants ; Treatment Outcome ; Ultrasonic imaging ; Ventricle</subject><ispartof>The American journal of cardiology, 2024-01, Vol.211, p.106-111</ispartof><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><rights>2023. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c285t-93e639ff7b4332e442e6034024e2e827ec31462d7c45403d865d49a50d210e2b3</cites><orcidid>0000-0002-5340-8603</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37949338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshikawa, Masafumi</creatorcontrib><creatorcontrib>Arashi, Hiroyuki</creatorcontrib><creatorcontrib>Kikuchi, Noriko</creatorcontrib><creatorcontrib>Koyanagi-Saito, Chihiro</creatorcontrib><creatorcontrib>Domoto, Satoru</creatorcontrib><creatorcontrib>Niinami, Hiroshi</creatorcontrib><creatorcontrib>Yamaguchi, Junichi</creatorcontrib><title>Increased Left Ventricular End-Diastolic Volume Index Is Associated With Increased Adverse Events After MitraClip Implantation</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>This study investigated the association between the left ventricular end-diastolic volume index (LVEDVI) and the incidence of adverse clinical events in patients after MitraClip implantation. In this retrospective, observational study, 123 patients who underwent the MitraClip procedure were enrolled. Participants were divided into 2 groups according to the LVEDVI cut-off level, calculated using receiver operating characteristic curve analysis, to predict the primary end point and the occurrence of cardiovascular events was compared between the groups. The primary end point was all-cause mortality and hospitalization because of heart failure. The receiver operating characteristic curve analysis for the composite primary end point revealed an LVEDVI cut-off point of 118 ml/m
. Based on this threshold, 61 patients (49.6%) were categorized into the LVEDVI <118 ml/m
group, whereas 62 (50.4%) fell into the LVEDVI ≥118 ml/m
group. Over a median follow-up period of 336 days (interquartile range 80 to 667), the primary end points occurred in 15 and 26 patients in the LVEDVI <118 and LVEDVI ≥118 ml/m
groups, corresponding to incidence rates of 24.6% and 41.9%, respectively. Patients in the LVEDVI ≥118 ml/m
group demonstrated a significantly higher risk of adverse clinical events than those in the LVEDVI <118 ml/m
group (hazard ratio 2.24, 95% confidence interval 1.17 to 4.28, p = 0.01). This trend persisted even after adjusting for several confounders (p = 0.02). In conclusion, increased LVEDVI values were associated with increased adverse clinical events after MitraClip implantation in patients with severe mitral valve regurgitation.</description><subject>Congestive heart failure</subject><subject>Cut-off</subject><subject>Ejection fraction</subject><subject>Heart failure</subject><subject>Heart Valve Prosthesis Implantation - methods</subject><subject>Humans</subject><subject>Implantation</subject><subject>Mitral valve</subject><subject>Mitral Valve Insufficiency</subject><subject>Mortality</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Pulmonary arteries</subject><subject>Regression analysis</subject><subject>Regurgitation</subject><subject>Retrospective Studies</subject><subject>Stroke Volume</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><subject>Ventricle</subject><issn>0002-9149</issn><issn>1879-1913</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtrGzEURkVpaBynP6FF0E024-g1Dy2N4zYDDtm0zlLI0h2qYR6upDHJJr89MnZa6OpyL-f7uHAQ-kLJghJa3LYL3bdGe7tghPF0WxBJPqAZrUqZUUn5RzQjhLBMUiEv0VUIbVopzYtP6JKXUkjOqxl6rQfjQQeweANNxFsYondm6rTH68Fmd06HOHbO4O3YTT3gerDwjOuAlyGMxumYkk8u_sb_ipb2AD4AXh9SWQKbCB4_uOj1qnN7XPf7Tg9RRzcO1-ii0V2Az-c5R7--r3-u7rPN4496tdxkhlV5zCSHgsumKXeCcwZCMCgIF4QJYFCxEgynomC2NCIXhNuqyK2QOieWUQJsx-fo5tS79-OfCUJUvQsGuvQIjFNQrKok4zIvSUK__Ye24-SH9J1ikshCUJnzROUnyvgxBA-N2nvXa_-iKFFHQapVZ0HqKOh4ToJS7uu5fdr1YP-m3o3wN7kQjc0</recordid><startdate>20240115</startdate><enddate>20240115</enddate><creator>Yoshikawa, Masafumi</creator><creator>Arashi, Hiroyuki</creator><creator>Kikuchi, Noriko</creator><creator>Koyanagi-Saito, Chihiro</creator><creator>Domoto, Satoru</creator><creator>Niinami, Hiroshi</creator><creator>Yamaguchi, Junichi</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5340-8603</orcidid></search><sort><creationdate>20240115</creationdate><title>Increased Left Ventricular End-Diastolic Volume Index Is Associated With Increased Adverse Events After MitraClip Implantation</title><author>Yoshikawa, Masafumi ; Arashi, Hiroyuki ; Kikuchi, Noriko ; Koyanagi-Saito, Chihiro ; Domoto, Satoru ; Niinami, Hiroshi ; Yamaguchi, Junichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-93e639ff7b4332e442e6034024e2e827ec31462d7c45403d865d49a50d210e2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Congestive heart failure</topic><topic>Cut-off</topic><topic>Ejection fraction</topic><topic>Heart failure</topic><topic>Heart Valve Prosthesis Implantation - methods</topic><topic>Humans</topic><topic>Implantation</topic><topic>Mitral valve</topic><topic>Mitral Valve Insufficiency</topic><topic>Mortality</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Pulmonary arteries</topic><topic>Regression analysis</topic><topic>Regurgitation</topic><topic>Retrospective Studies</topic><topic>Stroke Volume</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Ultrasonic imaging</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshikawa, Masafumi</creatorcontrib><creatorcontrib>Arashi, Hiroyuki</creatorcontrib><creatorcontrib>Kikuchi, Noriko</creatorcontrib><creatorcontrib>Koyanagi-Saito, Chihiro</creatorcontrib><creatorcontrib>Domoto, Satoru</creatorcontrib><creatorcontrib>Niinami, Hiroshi</creatorcontrib><creatorcontrib>Yamaguchi, Junichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshikawa, Masafumi</au><au>Arashi, Hiroyuki</au><au>Kikuchi, Noriko</au><au>Koyanagi-Saito, Chihiro</au><au>Domoto, Satoru</au><au>Niinami, Hiroshi</au><au>Yamaguchi, Junichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Left Ventricular End-Diastolic Volume Index Is Associated With Increased Adverse Events After MitraClip Implantation</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2024-01-15</date><risdate>2024</risdate><volume>211</volume><spage>106</spage><epage>111</epage><pages>106-111</pages><issn>0002-9149</issn><issn>1879-1913</issn><eissn>1879-1913</eissn><abstract>This study investigated the association between the left ventricular end-diastolic volume index (LVEDVI) and the incidence of adverse clinical events in patients after MitraClip implantation. In this retrospective, observational study, 123 patients who underwent the MitraClip procedure were enrolled. Participants were divided into 2 groups according to the LVEDVI cut-off level, calculated using receiver operating characteristic curve analysis, to predict the primary end point and the occurrence of cardiovascular events was compared between the groups. The primary end point was all-cause mortality and hospitalization because of heart failure. The receiver operating characteristic curve analysis for the composite primary end point revealed an LVEDVI cut-off point of 118 ml/m
. Based on this threshold, 61 patients (49.6%) were categorized into the LVEDVI <118 ml/m
group, whereas 62 (50.4%) fell into the LVEDVI ≥118 ml/m
group. Over a median follow-up period of 336 days (interquartile range 80 to 667), the primary end points occurred in 15 and 26 patients in the LVEDVI <118 and LVEDVI ≥118 ml/m
groups, corresponding to incidence rates of 24.6% and 41.9%, respectively. Patients in the LVEDVI ≥118 ml/m
group demonstrated a significantly higher risk of adverse clinical events than those in the LVEDVI <118 ml/m
group (hazard ratio 2.24, 95% confidence interval 1.17 to 4.28, p = 0.01). This trend persisted even after adjusting for several confounders (p = 0.02). In conclusion, increased LVEDVI values were associated with increased adverse clinical events after MitraClip implantation in patients with severe mitral valve regurgitation.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>37949338</pmid><doi>10.1016/j.amjcard.2023.10.090</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5340-8603</orcidid></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Congestive heart failure Cut-off Ejection fraction Heart failure Heart Valve Prosthesis Implantation - methods Humans Implantation Mitral valve Mitral Valve Insufficiency Mortality Observational studies Patients Pulmonary arteries Regression analysis Regurgitation Retrospective Studies Stroke Volume Transplants & implants Treatment Outcome Ultrasonic imaging Ventricle |
| title | Increased Left Ventricular End-Diastolic Volume Index Is Associated With Increased Adverse Events After MitraClip Implantation |
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