A DNA methylation haplotype block landscape in human tissues and preimplantation embryos reveals regulatory elements defined by comethylation patterns

DNA methylation and associated regulatory elements play a crucial role in gene expression regulation. Previous studies have focused primarily on the distribution of mean methylation levels. Advances in whole-genome bisulfite sequencing (WGBS) have enabled the characterization of DNA methylation hapl...

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Veröffentlicht in:	Genome research 2023-12, Vol.33 (12), p.2041-2052
Hauptverfasser:	Feng, Yan, Zhang, Zhiqiang, Hong, Yuyang, Ding, Yi, Liu, Leiqin, Gao, Siqi, Fang, Hai, Shi, Jiantao
Format:	Artikel
Sprache:	eng
Schlagworte:	Bisulfite Blastocyst - metabolism Chromatin Chromosomes CpG Islands DNA Methylation Embryogenesis Embryonic Development - genetics Enhancer Elements, Genetic Enhancers Gene expression Gene Expression Regulation, Developmental Genome, Human Genomes Haplotypes Histones Humans Organ Specificity Regulatory sequences Regulatory Sequences, Nucleic Acid
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