An illness–death multistate model to implement delta adjustment and reference‐based imputation with time‐to‐event endpoints

With a treatment policy strategy, therapies are evaluated regardless of the disturbance caused by intercurrent events (ICEs). Implementing this estimand is challenging if subjects are not followed up after the ICE. This circumstance can be dealt with using delta adjustment (DA) or reference‐based (R...

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Veröffentlicht in:	Pharmaceutical statistics : the journal of the pharmaceutical industry 2024-03, Vol.23 (2), p.219-241
Hauptverfasser:	García‐Hernandez, Alberto, Pérez, Teresa, Carmen Pardo, María, Rizopoulos, Dimitris
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Probability
Online-Zugang:	Volltext
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