Discovery of a novel tetrahydroimidazo1,2-apyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach

Heparanase-1 (HPSE1) is an endo-β-d-glucuronidase that catalyzes degradation of heparan sulfate proteoglycans. Inhibition of HPSE1 appears to be a useful therapeutic target against cancer and proteinuric kidney diseases. We previously reported tetrahydroimidazo[1,2-a]pyridine 2 as a potent HPSE1 inh...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2024-01, Vol.97, p.129543
Hauptverfasser:	Imai, Yudai, Suzuki, Ryo, Matsuda, Daisuke, Tanaka-Yamamoto, Nozomi, Ohki, Yuta, Tabata, Ryotaro, Kato, Sota, Sugisaki, Mami, Fujimoto, Natsuko, Fukunaga, Takuya, Kato, Sayaka, Takahashi, Teisuke, Kakinuma, Hiroyuki
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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