Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes

An efficient protocol for the synthesis of novel methotrexate-betulonic acid hybrids with a (tert-butoxycarbonylamino)-3,6-dioxa-8-octanamine (Boc-DOOA) linkage has been developed. Reaction of N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-betulonamide with methotrexate resulted in a mixture of isomeric conju...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Steroids 2024-01, Vol.201, p.109332-109332, Article 109332
Hauptverfasser:	Semenenko, Olexander M, Lipson, Victoria V, Sadchenko, Alina O, Vashchenko, Olga V, Kasian, Natalia A, Sviechnikova, Liliia V, Lisetski, Longin M, Babak, Mykola L, Vakula, Volodymyr M, Borysov, Oleksandr V, Holota, Yuliia V, Zozulya, Sergey O, Borysko, Petro O, Mazepa, Olexander V
Format:	Artikel
Sprache:	eng
Schlagworte:	Betulinic Acid Caco-2 Cells Cell Membrane Humans Membranes, Artificial Methotrexate Oleanolic Acid - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!