An overview of multimorbidity and polypharmacy in older people living with HIV
The availability of effective antiretroviral therapy (ART) has revolutionized the care of people living with HIV (PLHIV). As a result, PLHIV now have a life expectancy comparable with that of the general population. PLHIV are increasingly confronted with age‐related comorbidities and geriatric syndr...
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| Veröffentlicht in: | Geriatrics & gerontology international 2024-03, Vol.24 (S1), p.49-59 |
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| creator | Yang, Chen Teh, Yii Ean Chua, Nathalie Grace Sy Lee, Kiat Loon Simon Ng, Rachel Qiao Ming |
| description | The availability of effective antiretroviral therapy (ART) has revolutionized the care of people living with HIV (PLHIV). As a result, PLHIV now have a life expectancy comparable with that of the general population. PLHIV are increasingly confronted with age‐related comorbidities and geriatric syndromes, including frailty and polypharmacy, which occur at a higher prevalence and set in at an earlier age compared with their uninfected counterparts. The underlying pathophysiology for multimorbidity and polypharmacy are multifactorial, multidimensional and complex. Therefore, regular review and optimization of risk factors to maintain physical function, social and psychological health is of utmost importance. With an ever‐growing population of older PLHIV, there is a pressing need to provide holistic care to address these emerging issues. Accelerated aging observed in PLHIV suggests that early involvement of a multidisciplinary team, including geriatricians, and implementation of integrated models of care can potentially improve the care of older PLHIV, who are at increased risk of frailty and complex multimorbidity. This article reviews the current global situation, discusses the challenges involved and suggests approaches to deliver comprehensive care for older PLHIV. Geriatr Gerontol Int 2024; 24: 49–59.
People living with HIV (PLHIV) are increasingly confronted with age‐related comorbidities and geriatric syndromes, including frailty and polypharmacy, which occur at a higher prevalence and set in at an earlier age compared with their uninfected counterparts. Therefore, early involvement of a multidisciplinary team, including geriatricians, and implementation of integrated models of care can potentially improve the care of older PLHIV, who are at increased risk of frailty and complex multimorbidity. This article reviews the current global situation, discusses the challenges involved and suggests approaches to deliver comprehensive care for older PLHIV. |
| doi_str_mv | 10.1111/ggi.14717 |
| format | Article |
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People living with HIV (PLHIV) are increasingly confronted with age‐related comorbidities and geriatric syndromes, including frailty and polypharmacy, which occur at a higher prevalence and set in at an earlier age compared with their uninfected counterparts. Therefore, early involvement of a multidisciplinary team, including geriatricians, and implementation of integrated models of care can potentially improve the care of older PLHIV, who are at increased risk of frailty and complex multimorbidity. This article reviews the current global situation, discusses the challenges involved and suggests approaches to deliver comprehensive care for older PLHIV.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.14717</identifier><identifier>PMID: 37940135</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Aged ; Aging ; Antiretroviral drugs ; Clinical outcomes ; Comorbidity ; Drug interactions ; Frailty ; Frailty - epidemiology ; Frailty - therapy ; geriatric syndromes ; Geriatrics ; Health risks ; HIV ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Integrated delivery systems ; Multimorbidity ; older adults ; Older people ; Patient-centered care ; people living with HIV ; Polypharmacy ; Psychological aspects ; Quality of life ; Social support</subject><ispartof>Geriatrics & gerontology international, 2024-03, Vol.24 (S1), p.49-59</ispartof><rights>2023 Japan Geriatrics Society.</rights><rights>2024 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3137-fded70bee58f11c85894079617bbff28c48211feba86358108ffe5ce8fe8c8fa3</cites><orcidid>0000-0002-8166-812X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fggi.14717$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fggi.14717$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37940135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Chen</creatorcontrib><creatorcontrib>Teh, Yii Ean</creatorcontrib><creatorcontrib>Chua, Nathalie Grace Sy</creatorcontrib><creatorcontrib>Lee, Kiat Loon Simon</creatorcontrib><creatorcontrib>Ng, Rachel Qiao Ming</creatorcontrib><title>An overview of multimorbidity and polypharmacy in older people living with HIV</title><title>Geriatrics & gerontology international</title><addtitle>Geriatr Gerontol Int</addtitle><description>The availability of effective antiretroviral therapy (ART) has revolutionized the care of people living with HIV (PLHIV). As a result, PLHIV now have a life expectancy comparable with that of the general population. PLHIV are increasingly confronted with age‐related comorbidities and geriatric syndromes, including frailty and polypharmacy, which occur at a higher prevalence and set in at an earlier age compared with their uninfected counterparts. The underlying pathophysiology for multimorbidity and polypharmacy are multifactorial, multidimensional and complex. Therefore, regular review and optimization of risk factors to maintain physical function, social and psychological health is of utmost importance. With an ever‐growing population of older PLHIV, there is a pressing need to provide holistic care to address these emerging issues. Accelerated aging observed in PLHIV suggests that early involvement of a multidisciplinary team, including geriatricians, and implementation of integrated models of care can potentially improve the care of older PLHIV, who are at increased risk of frailty and complex multimorbidity. This article reviews the current global situation, discusses the challenges involved and suggests approaches to deliver comprehensive care for older PLHIV. Geriatr Gerontol Int 2024; 24: 49–59.
People living with HIV (PLHIV) are increasingly confronted with age‐related comorbidities and geriatric syndromes, including frailty and polypharmacy, which occur at a higher prevalence and set in at an earlier age compared with their uninfected counterparts. Therefore, early involvement of a multidisciplinary team, including geriatricians, and implementation of integrated models of care can potentially improve the care of older PLHIV, who are at increased risk of frailty and complex multimorbidity. This article reviews the current global situation, discusses the challenges involved and suggests approaches to deliver comprehensive care for older PLHIV.</description><subject>Aged</subject><subject>Aging</subject><subject>Antiretroviral drugs</subject><subject>Clinical outcomes</subject><subject>Comorbidity</subject><subject>Drug interactions</subject><subject>Frailty</subject><subject>Frailty - epidemiology</subject><subject>Frailty - therapy</subject><subject>geriatric syndromes</subject><subject>Geriatrics</subject><subject>Health risks</subject><subject>HIV</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Integrated delivery systems</subject><subject>Multimorbidity</subject><subject>older adults</subject><subject>Older people</subject><subject>Patient-centered care</subject><subject>people living with HIV</subject><subject>Polypharmacy</subject><subject>Psychological aspects</subject><subject>Quality of life</subject><subject>Social support</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PGzEQQC1URCBw4A9UlnppDwue_fLsESEaIiG4AFdrP8aJI-96680m2n9fQ6CHSsxl5vD0NHqMXYK4gjDXq5W5glSCPGKnkKYyElmRfnu_0wgyzGfsbBg2QoAsAE7YLJFFKiDJTtnjTcfdjvzO0J47zdvRbk3rfGUas5142TW8d3bq16Vvy3riJuC2Ic97cr0lbs3OdCu-N9s1v1--nrNjXdqBLj72nL38vnu-vY8enhbL25uHqE4gkZFuqJGiIspQA9SYYfhHFjnIqtI6xjrFGEBTVWKeZAgCtaasJtSENeoymbOfB2_v3Z-Rhq1qzVCTtWVHbhxUjIgiARQyoD_-Qzdu9F34TsXFW4c4zzFQvw5U7d0weNKq96Yt_aRAqLfIKkRW75ED-_3DOFYtNf_Iz6oBuD4Ae2Np-tqkFovlQfkXJIOFrA</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Yang, Chen</creator><creator>Teh, Yii Ean</creator><creator>Chua, Nathalie Grace Sy</creator><creator>Lee, Kiat Loon Simon</creator><creator>Ng, Rachel Qiao Ming</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8166-812X</orcidid></search><sort><creationdate>202403</creationdate><title>An overview of multimorbidity and polypharmacy in older people living with HIV</title><author>Yang, Chen ; Teh, Yii Ean ; Chua, Nathalie Grace Sy ; Lee, Kiat Loon Simon ; Ng, Rachel Qiao Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3137-fded70bee58f11c85894079617bbff28c48211feba86358108ffe5ce8fe8c8fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Antiretroviral drugs</topic><topic>Clinical outcomes</topic><topic>Comorbidity</topic><topic>Drug interactions</topic><topic>Frailty</topic><topic>Frailty - epidemiology</topic><topic>Frailty - therapy</topic><topic>geriatric syndromes</topic><topic>Geriatrics</topic><topic>Health risks</topic><topic>HIV</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Integrated delivery systems</topic><topic>Multimorbidity</topic><topic>older adults</topic><topic>Older people</topic><topic>Patient-centered care</topic><topic>people living with HIV</topic><topic>Polypharmacy</topic><topic>Psychological aspects</topic><topic>Quality of life</topic><topic>Social support</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Chen</creatorcontrib><creatorcontrib>Teh, Yii Ean</creatorcontrib><creatorcontrib>Chua, Nathalie Grace Sy</creatorcontrib><creatorcontrib>Lee, Kiat Loon Simon</creatorcontrib><creatorcontrib>Ng, Rachel Qiao Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Chen</au><au>Teh, Yii Ean</au><au>Chua, Nathalie Grace Sy</au><au>Lee, Kiat Loon Simon</au><au>Ng, Rachel Qiao Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An overview of multimorbidity and polypharmacy in older people living with HIV</atitle><jtitle>Geriatrics & gerontology international</jtitle><addtitle>Geriatr Gerontol Int</addtitle><date>2024-03</date><risdate>2024</risdate><volume>24</volume><issue>S1</issue><spage>49</spage><epage>59</epage><pages>49-59</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>The availability of effective antiretroviral therapy (ART) has revolutionized the care of people living with HIV (PLHIV). As a result, PLHIV now have a life expectancy comparable with that of the general population. PLHIV are increasingly confronted with age‐related comorbidities and geriatric syndromes, including frailty and polypharmacy, which occur at a higher prevalence and set in at an earlier age compared with their uninfected counterparts. The underlying pathophysiology for multimorbidity and polypharmacy are multifactorial, multidimensional and complex. Therefore, regular review and optimization of risk factors to maintain physical function, social and psychological health is of utmost importance. With an ever‐growing population of older PLHIV, there is a pressing need to provide holistic care to address these emerging issues. Accelerated aging observed in PLHIV suggests that early involvement of a multidisciplinary team, including geriatricians, and implementation of integrated models of care can potentially improve the care of older PLHIV, who are at increased risk of frailty and complex multimorbidity. This article reviews the current global situation, discusses the challenges involved and suggests approaches to deliver comprehensive care for older PLHIV. Geriatr Gerontol Int 2024; 24: 49–59.
People living with HIV (PLHIV) are increasingly confronted with age‐related comorbidities and geriatric syndromes, including frailty and polypharmacy, which occur at a higher prevalence and set in at an earlier age compared with their uninfected counterparts. Therefore, early involvement of a multidisciplinary team, including geriatricians, and implementation of integrated models of care can potentially improve the care of older PLHIV, who are at increased risk of frailty and complex multimorbidity. This article reviews the current global situation, discusses the challenges involved and suggests approaches to deliver comprehensive care for older PLHIV.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>37940135</pmid><doi>10.1111/ggi.14717</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8166-812X</orcidid></addata></record> |
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| subjects | Aged Aging Antiretroviral drugs Clinical outcomes Comorbidity Drug interactions Frailty Frailty - epidemiology Frailty - therapy geriatric syndromes Geriatrics Health risks HIV HIV Infections - drug therapy HIV Infections - epidemiology Human immunodeficiency virus Humans Integrated delivery systems Multimorbidity older adults Older people Patient-centered care people living with HIV Polypharmacy Psychological aspects Quality of life Social support |
| title | An overview of multimorbidity and polypharmacy in older people living with HIV |
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