New-generation cytopharmaceuticals with powerfully boosted extravasation for enhanced cancer therapy

Effective extravasation of therapeutic agents into solid tumors still faces huge challenges. Since the doubted effectiveness of enhanced penetration and retention effect, first-generation neutrophil cytopharmaceuticals with encapsulated drugs have been developed to improve the drug accumulation in t...

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Veröffentlicht in:	Journal of controlled release 2023-07, Vol.359, p.116-131
Hauptverfasser:	Zhang, Luping, Wang, Qianqian, Dai, Yupeng, Chen, Jiaqi, Wu, Tong, Ju, Caoyun, Xue, Lingjing, Zhang, Can
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Anti-angiogenesis Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use cancer therapy Cell Adhesion Cell membrane-anchoring strategy chemotaxis Chemotherapeutics cytotoxicity drug therapy drugs encapsulation endocytosis endothelium Endothelium, Vascular Enhanced extravasation Humans neoplasms Neoplasms - drug therapy Neutrophil cytopharmaceuticals neutrophils peptides Peptides - pharmacology Peptides - therapeutic use Vascular Endothelial Growth Factor A - pharmacology vascular endothelial growth factor receptor-2
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