Intermittent fasting associated with aerobic exercise improves oxidative parameters and causes muscle damage without compromising the performance of Wistar rats
•Intermittent fasting and exercise reduced body weight and lean mass.•Intermittent fasting did not change physical performance during aerobic exercise.•Intermittent fasting combined with aerobic exercise decreased homeostatic model assessment for insulin resistance, low-density lipoprotein, lactate...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2023-11, Vol.115, p.112159-112159, Article 112159 |
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| creator | Dorand, Victor Augusto Mathias Soares, Naís Lira da Silva Andrade, Artur D' Angelo Ribeiro, Mateus Duarte de Almeida Filho, Eder Jackson Bezerra Neto, Manoel Miranda Batista, Kamila Sabino de Oliveira, Guilherme Costa Alves, Adriano Francisco de Paiva Sousa, Maria Carolina Silva, Alexandre Sergio Aquino, Jailane de Souza |
| description | •Intermittent fasting and exercise reduced body weight and lean mass.•Intermittent fasting did not change physical performance during aerobic exercise.•Intermittent fasting combined with aerobic exercise decreased homeostatic model assessment for insulin resistance, low-density lipoprotein, lactate dehydrogenase, and metabolic index.•Intermittent fasting and exercise increased total antioxidant capacity in soleus and in extensor digitorum longus muscles.•Intermittent fasting and exercise caused muscle fiber damage, with increase in the positivity marking for tumor necrosis factor-α.
The aim of this study was to` investigate the effects of intermittent fasting (IF) and the possible association with aerobic exercise on performance, oxidative, biochemical, and somatic parameters of Wistar rats.
Forty rats were randomized into the following groups: sedentary (SC) and trained (TC) controls, sedentary intermittent fasting (SIF), and trained intermittent fasting (TIF). The rats were subjected to IF for 15 h every day and aerobic exercise lasting 30 min, five times a week, at a speed of 15 m/min for 4 wk. Performance tests were performed at the beginning and end of the protocol. Glucose and insulin tolerance, somatic parameters, lipidogram, leptin, insulin, malondialdehyde, antioxidant capacity, C-reactive protein, alpha acid glycoprotein, creatine kinase, lactate dehydrogenase, and muscle histology were analyzed.
The trained groups had similar performance and significantly improved performance at the end of the experiment. TIF showed lower body weight (–16 g), lean mass (22.49%), homeostatic model assessment for insulin resistance (29%), and lactate dehydrogenase (48%), and higher malondialdehyde (53%) and antioxidant capacity (75%) than the TC group. The SIF and TIF groups showed a fiber area reduction and positivity marking for tumor necrosis factor-α in the muscles.
Although IF associated with aerobic exercise improved antioxidant capacity caused damage to muscle fibers and lean mass loss, it did not change the performance of the rats.
[Display omitted] |
| doi_str_mv | 10.1016/j.nut.2023.112159 |
| format | Article |
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The aim of this study was to` investigate the effects of intermittent fasting (IF) and the possible association with aerobic exercise on performance, oxidative, biochemical, and somatic parameters of Wistar rats.
Forty rats were randomized into the following groups: sedentary (SC) and trained (TC) controls, sedentary intermittent fasting (SIF), and trained intermittent fasting (TIF). The rats were subjected to IF for 15 h every day and aerobic exercise lasting 30 min, five times a week, at a speed of 15 m/min for 4 wk. Performance tests were performed at the beginning and end of the protocol. Glucose and insulin tolerance, somatic parameters, lipidogram, leptin, insulin, malondialdehyde, antioxidant capacity, C-reactive protein, alpha acid glycoprotein, creatine kinase, lactate dehydrogenase, and muscle histology were analyzed.
The trained groups had similar performance and significantly improved performance at the end of the experiment. TIF showed lower body weight (–16 g), lean mass (22.49%), homeostatic model assessment for insulin resistance (29%), and lactate dehydrogenase (48%), and higher malondialdehyde (53%) and antioxidant capacity (75%) than the TC group. The SIF and TIF groups showed a fiber area reduction and positivity marking for tumor necrosis factor-α in the muscles.
Although IF associated with aerobic exercise improved antioxidant capacity caused damage to muscle fibers and lean mass loss, it did not change the performance of the rats.
[Display omitted]</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2023.112159</identifier><identifier>PMID: 37549455</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aerobic capacity ; Aerobics ; alpha acids ; Animal models ; antioxidant activity ; Antioxidant capacity ; Antioxidants ; Body composition ; Body weight ; C-reactive protein ; Cloning ; Creatine ; Creatine kinase ; Damage ; Dehydrogenase ; Exercise ; Fasting ; Fitness equipment ; Food ; Glucose ; Glucose tolerance ; Glycoproteins ; Histology ; Inflammatory markers ; Insulin ; Insulin resistance ; Kinases ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Leptin ; Lipoproteins ; Malondialdehyde ; Medical research ; Metabolism ; Muscle fiber ; Muscles ; necrosis ; neoplasms ; nutrition ; Parameters ; Performance tests ; Physical fitness ; Running ; Time-restricted feeding ; Tumor necrosis factor-TNF</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2023-11, Vol.115, p.112159-112159, Article 112159</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><rights>2023. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-fe803c7e9a41d4b4a1cbf1be37d16a6db5681f8d67a875a355f3c5b6e47e6de83</citedby><cites>FETCH-LOGICAL-c414t-fe803c7e9a41d4b4a1cbf1be37d16a6db5681f8d67a875a355f3c5b6e47e6de83</cites><orcidid>0000-0002-5262-980X ; 0000-0002-4870-3130 ; 0000-0003-3576-9023 ; 0000-0003-4449-2169 ; 0000-0003-2458-9449 ; 0000-0002-7221-9867</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0899900723001879$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37549455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dorand, Victor Augusto Mathias</creatorcontrib><creatorcontrib>Soares, Naís Lira</creatorcontrib><creatorcontrib>da Silva Andrade, Artur D' Angelo</creatorcontrib><creatorcontrib>Ribeiro, Mateus Duarte</creatorcontrib><creatorcontrib>de Almeida Filho, Eder Jackson Bezerra</creatorcontrib><creatorcontrib>Neto, Manoel Miranda</creatorcontrib><creatorcontrib>Batista, Kamila Sabino</creatorcontrib><creatorcontrib>de Oliveira, Guilherme Costa</creatorcontrib><creatorcontrib>Alves, Adriano Francisco</creatorcontrib><creatorcontrib>de Paiva Sousa, Maria Carolina</creatorcontrib><creatorcontrib>Silva, Alexandre Sergio</creatorcontrib><creatorcontrib>Aquino, Jailane de Souza</creatorcontrib><title>Intermittent fasting associated with aerobic exercise improves oxidative parameters and causes muscle damage without compromising the performance of Wistar rats</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>•Intermittent fasting and exercise reduced body weight and lean mass.•Intermittent fasting did not change physical performance during aerobic exercise.•Intermittent fasting combined with aerobic exercise decreased homeostatic model assessment for insulin resistance, low-density lipoprotein, lactate dehydrogenase, and metabolic index.•Intermittent fasting and exercise increased total antioxidant capacity in soleus and in extensor digitorum longus muscles.•Intermittent fasting and exercise caused muscle fiber damage, with increase in the positivity marking for tumor necrosis factor-α.
The aim of this study was to` investigate the effects of intermittent fasting (IF) and the possible association with aerobic exercise on performance, oxidative, biochemical, and somatic parameters of Wistar rats.
Forty rats were randomized into the following groups: sedentary (SC) and trained (TC) controls, sedentary intermittent fasting (SIF), and trained intermittent fasting (TIF). The rats were subjected to IF for 15 h every day and aerobic exercise lasting 30 min, five times a week, at a speed of 15 m/min for 4 wk. Performance tests were performed at the beginning and end of the protocol. Glucose and insulin tolerance, somatic parameters, lipidogram, leptin, insulin, malondialdehyde, antioxidant capacity, C-reactive protein, alpha acid glycoprotein, creatine kinase, lactate dehydrogenase, and muscle histology were analyzed.
The trained groups had similar performance and significantly improved performance at the end of the experiment. TIF showed lower body weight (–16 g), lean mass (22.49%), homeostatic model assessment for insulin resistance (29%), and lactate dehydrogenase (48%), and higher malondialdehyde (53%) and antioxidant capacity (75%) than the TC group. The SIF and TIF groups showed a fiber area reduction and positivity marking for tumor necrosis factor-α in the muscles.
Although IF associated with aerobic exercise improved antioxidant capacity caused damage to muscle fibers and lean mass loss, it did not change the performance of the rats.
[Display omitted]</description><subject>Aerobic capacity</subject><subject>Aerobics</subject><subject>alpha acids</subject><subject>Animal models</subject><subject>antioxidant activity</subject><subject>Antioxidant capacity</subject><subject>Antioxidants</subject><subject>Body composition</subject><subject>Body weight</subject><subject>C-reactive protein</subject><subject>Cloning</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Damage</subject><subject>Dehydrogenase</subject><subject>Exercise</subject><subject>Fasting</subject><subject>Fitness equipment</subject><subject>Food</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Glycoproteins</subject><subject>Histology</subject><subject>Inflammatory markers</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Leptin</subject><subject>Lipoproteins</subject><subject>Malondialdehyde</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Muscle fiber</subject><subject>Muscles</subject><subject>necrosis</subject><subject>neoplasms</subject><subject>nutrition</subject><subject>Parameters</subject><subject>Performance tests</subject><subject>Physical fitness</subject><subject>Running</subject><subject>Time-restricted feeding</subject><subject>Tumor necrosis 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fasting associated with aerobic exercise improves oxidative parameters and causes muscle damage without compromising the performance of Wistar rats</title><author>Dorand, Victor Augusto Mathias ; Soares, Naís Lira ; da Silva Andrade, Artur D' Angelo ; Ribeiro, Mateus Duarte ; de Almeida Filho, Eder Jackson Bezerra ; Neto, Manoel Miranda ; Batista, Kamila Sabino ; de Oliveira, Guilherme Costa ; Alves, Adriano Francisco ; de Paiva Sousa, Maria Carolina ; Silva, Alexandre Sergio ; Aquino, Jailane de Souza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-fe803c7e9a41d4b4a1cbf1be37d16a6db5681f8d67a875a355f3c5b6e47e6de83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aerobic capacity</topic><topic>Aerobics</topic><topic>alpha acids</topic><topic>Animal models</topic><topic>antioxidant activity</topic><topic>Antioxidant capacity</topic><topic>Antioxidants</topic><topic>Body composition</topic><topic>Body weight</topic><topic>C-reactive protein</topic><topic>Cloning</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Damage</topic><topic>Dehydrogenase</topic><topic>Exercise</topic><topic>Fasting</topic><topic>Fitness equipment</topic><topic>Food</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Glycoproteins</topic><topic>Histology</topic><topic>Inflammatory markers</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactate dehydrogenase</topic><topic>Lactic acid</topic><topic>Leptin</topic><topic>Lipoproteins</topic><topic>Malondialdehyde</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Muscle fiber</topic><topic>Muscles</topic><topic>necrosis</topic><topic>neoplasms</topic><topic>nutrition</topic><topic>Parameters</topic><topic>Performance tests</topic><topic>Physical 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with aerobic exercise improves oxidative parameters and causes muscle damage without compromising the performance of Wistar rats</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>115</volume><spage>112159</spage><epage>112159</epage><pages>112159-112159</pages><artnum>112159</artnum><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>•Intermittent fasting and exercise reduced body weight and lean mass.•Intermittent fasting did not change physical performance during aerobic exercise.•Intermittent fasting combined with aerobic exercise decreased homeostatic model assessment for insulin resistance, low-density lipoprotein, lactate dehydrogenase, and metabolic index.•Intermittent fasting and exercise increased total antioxidant capacity in soleus and in extensor digitorum longus muscles.•Intermittent fasting and exercise caused muscle fiber damage, with increase in the positivity marking for tumor necrosis factor-α.
The aim of this study was to` investigate the effects of intermittent fasting (IF) and the possible association with aerobic exercise on performance, oxidative, biochemical, and somatic parameters of Wistar rats.
Forty rats were randomized into the following groups: sedentary (SC) and trained (TC) controls, sedentary intermittent fasting (SIF), and trained intermittent fasting (TIF). The rats were subjected to IF for 15 h every day and aerobic exercise lasting 30 min, five times a week, at a speed of 15 m/min for 4 wk. Performance tests were performed at the beginning and end of the protocol. Glucose and insulin tolerance, somatic parameters, lipidogram, leptin, insulin, malondialdehyde, antioxidant capacity, C-reactive protein, alpha acid glycoprotein, creatine kinase, lactate dehydrogenase, and muscle histology were analyzed.
The trained groups had similar performance and significantly improved performance at the end of the experiment. TIF showed lower body weight (–16 g), lean mass (22.49%), homeostatic model assessment for insulin resistance (29%), and lactate dehydrogenase (48%), and higher malondialdehyde (53%) and antioxidant capacity (75%) than the TC group. The SIF and TIF groups showed a fiber area reduction and positivity marking for tumor necrosis factor-α in the muscles.
Although IF associated with aerobic exercise improved antioxidant capacity caused damage to muscle fibers and lean mass loss, it did not change the performance of the rats.
[Display omitted]</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37549455</pmid><doi>10.1016/j.nut.2023.112159</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5262-980X</orcidid><orcidid>https://orcid.org/0000-0002-4870-3130</orcidid><orcidid>https://orcid.org/0000-0003-3576-9023</orcidid><orcidid>https://orcid.org/0000-0003-4449-2169</orcidid><orcidid>https://orcid.org/0000-0003-2458-9449</orcidid><orcidid>https://orcid.org/0000-0002-7221-9867</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2023-11, Vol.115, p.112159-112159, Article 112159 |
| issn | 0899-9007 1873-1244 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2887991704 |
| source | Elsevier ScienceDirect Journals |
| subjects | Aerobic capacity Aerobics alpha acids Animal models antioxidant activity Antioxidant capacity Antioxidants Body composition Body weight C-reactive protein Cloning Creatine Creatine kinase Damage Dehydrogenase Exercise Fasting Fitness equipment Food Glucose Glucose tolerance Glycoproteins Histology Inflammatory markers Insulin Insulin resistance Kinases L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Leptin Lipoproteins Malondialdehyde Medical research Metabolism Muscle fiber Muscles necrosis neoplasms nutrition Parameters Performance tests Physical fitness Running Time-restricted feeding Tumor necrosis factor-TNF |
| title | Intermittent fasting associated with aerobic exercise improves oxidative parameters and causes muscle damage without compromising the performance of Wistar rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T00%3A34%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intermittent%20fasting%20associated%20with%20aerobic%20exercise%20improves%20oxidative%20parameters%20and%20causes%20muscle%20damage%20without%20compromising%20the%20performance%20of%20Wistar%20rats&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=Dorand,%20Victor%20Augusto%20Mathias&rft.date=2023-11-01&rft.volume=115&rft.spage=112159&rft.epage=112159&rft.pages=112159-112159&rft.artnum=112159&rft.issn=0899-9007&rft.eissn=1873-1244&rft_id=info:doi/10.1016/j.nut.2023.112159&rft_dat=%3Cproquest_cross%3E2887991704%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2875880222&rft_id=info:pmid/37549455&rft_els_id=S0899900723001879&rfr_iscdi=true |