Ingenol mebutate inhibits the growth of pancreatic cancer cells in vitro via STING with an efficacy comparable to that of clinically used anticancer agents

Pancreatic cancer is associated with a poor prognosis; thus, there is an urgent need to develop new and effective treatments. Ingenol mebutate (IM), which is isolated from the latex of Euphorbia peplus , was recently shown to be effective against pancreatic cancer cell lines; however, its mechanism...

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Veröffentlicht in:Journal of natural medicines 2023-03, Vol.77 (2), p.343-351
Hauptverfasser: Kikuyama, Fumihiro, Suzuki, Sayo, Jibiki, Aya, Yokoyama, Yuta, Kawazoe, Hitoshi, Kitanaka, Susumu, Nakamura, Tomonori
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Sprache:eng
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