The impact of short-chain fatty acid–producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis
Introduction/objectives Persistent hyperuricemia is a key factor in gout; however, only 13.5% of hyperuricemic individuals manifest the disease. The gut microbiota could be one of the many factors underlying this phenomenon. We aimed to assess the difference in taxonomic and predicted functional pro...
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| Veröffentlicht in: | Clinical rheumatology 2023, Vol.42 (1), p.203-214 |
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| creator | Martínez-Nava, Gabriela A. Méndez-Salazar, Eder O. Vázquez-Mellado, Janitzia Zamudio-Cuevas, Yessica Francisco-Balderas, Adriana Martínez-Flores, Karina Fernández-Torres, Javier Lozada-Pérez, Carlos Guido-Gómora, Dafne L. Martínez-Gómez, Laura E. Jiménez-Gutiérrez, Guadalupe E. Pineda, Carlos Silveira, Luis H. Sánchez-Chapul, Laura Sánchez-Sánchez, Roberto Camacho-Rea, María del Carmen Martínez-Armenta, Carlos Burguete-García, Ana I. Orbe-Orihuela, Citlalli Lagunas-Martínez, Alfredo Palacios-González, Berenice López-Reyes, Alberto |
| description | Introduction/objectives
Persistent hyperuricemia is a key factor in gout; however, only 13.5% of hyperuricemic individuals manifest the disease. The gut microbiota could be one of the many factors underlying this phenomenon. We aimed to assess the difference in taxonomic and predicted functional profiles of the gut microbiota between asymptomatic hyperuricemia (AH) individuals and gout patients.
Methods
The V3–V4 region of the 16S rRNA gene of the gut microbiota of AH individuals, gout patients, and controls was sequenced. Bioinformatic analyses were carried out with QIIME2 and phyloseq to determine the difference in the relative abundance of bacterial genera among the study groups. Tax4fun2 was used to predict the functional profile of the gut microbiota.
Results
AH individuals presented a higher abundance of butyrate- and propionate-producing bacteria than gout patients; however, the latter had more bacteria capable of producing acetate. The abundance of
Prevotella
genus bacteria was not significantly different between the patients but was higher than that in controls. This result was corroborated by the functional profile, in which AH individuals had less pyruvate oxidase abundance than gout patients and less abundance of an enzyme that regulates glutamate synthetase activation than controls.
Conclusion
We observed a distinctive taxonomic profile in AH individuals characterized by a higher abundance of short-chain fatty acid-producing bacteria in comparison to those observed in gout patients. Furthermore, we provide scientific evidence that indicates that the gut microbiota of AH individuals could provide anti-inflammatory mediators, which prevent the appearance of gout flares.
Key Points
•
AH and gout patients both have a higher abundance of Prevotella genus bacteria than controls.
•
AH individuals’ gut microbiota had more butyrate- and propionate-producing bacteria than gout patients.
•
The gut microbiome of AH individuals provides anti-inflammatory mediators that could prevent gout flares. |
| doi_str_mv | 10.1007/s10067-022-06392-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2887609261</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2887609261</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-5f0c9a1d8cb3812f8c1c24e5a59fef80720fdbf2ad060d191665a244f60227a23</originalsourceid><addsrcrecordid>eNqFkbtuFDEUhi0EIpvAC1AgSzQ0huPLeuwSReEiRaIJteXxZdbRznixPcV2vEPekCfBYQNIFND4FP7-_1x-hF5QeEMBhre1v3IgwBgByTUj-hHaUMEF0Vrox2gDwwCEU63O0HmttwDAlKZP0RmXDChlfIPqzS7gNB-sazhHXHe5NOJ2Ni042taO2Lrkv3-7O5TsV5eWCY8dDSXZe7x18bQ2PCdX8phys7gLd8dDKGtJLswds4vHU-6QT3Zack31GXoS7b6G5w_1An15f3Vz-ZFcf_7w6fLdNXECVCPbCE5b6pUbuaIsKkcdE2FrtzqGqGBgEP0YmfUgwVNNpdxaJkSU_SKDZfwCvT759uG_rqE2M6fqwn5vl5DXaphSgwTNJP0_OjDGKadUdfTVX-htXsvSF-mUpKK7StEpdqL6YWotIZpDSbMtR0PB3KdnTumZPqv5mZ7RXfTywXod5-B_S37F1QF-Amr_WqZQ_vT-h-0Pjbml6g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2761428864</pqid></control><display><type>article</type><title>The impact of short-chain fatty acid–producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis</title><source>Springer Nature - Complete Springer Journals</source><creator>Martínez-Nava, Gabriela A. ; Méndez-Salazar, Eder O. ; Vázquez-Mellado, Janitzia ; Zamudio-Cuevas, Yessica ; Francisco-Balderas, Adriana ; Martínez-Flores, Karina ; Fernández-Torres, Javier ; Lozada-Pérez, Carlos ; Guido-Gómora, Dafne L. ; Martínez-Gómez, Laura E. ; Jiménez-Gutiérrez, Guadalupe E. ; Pineda, Carlos ; Silveira, Luis H. ; Sánchez-Chapul, Laura ; Sánchez-Sánchez, Roberto ; Camacho-Rea, María del Carmen ; Martínez-Armenta, Carlos ; Burguete-García, Ana I. ; Orbe-Orihuela, Citlalli ; Lagunas-Martínez, Alfredo ; Palacios-González, Berenice ; López-Reyes, Alberto</creator><creatorcontrib>Martínez-Nava, Gabriela A. ; Méndez-Salazar, Eder O. ; Vázquez-Mellado, Janitzia ; Zamudio-Cuevas, Yessica ; Francisco-Balderas, Adriana ; Martínez-Flores, Karina ; Fernández-Torres, Javier ; Lozada-Pérez, Carlos ; Guido-Gómora, Dafne L. ; Martínez-Gómez, Laura E. ; Jiménez-Gutiérrez, Guadalupe E. ; Pineda, Carlos ; Silveira, Luis H. ; Sánchez-Chapul, Laura ; Sánchez-Sánchez, Roberto ; Camacho-Rea, María del Carmen ; Martínez-Armenta, Carlos ; Burguete-García, Ana I. ; Orbe-Orihuela, Citlalli ; Lagunas-Martínez, Alfredo ; Palacios-González, Berenice ; López-Reyes, Alberto</creatorcontrib><description>Introduction/objectives
Persistent hyperuricemia is a key factor in gout; however, only 13.5% of hyperuricemic individuals manifest the disease. The gut microbiota could be one of the many factors underlying this phenomenon. We aimed to assess the difference in taxonomic and predicted functional profiles of the gut microbiota between asymptomatic hyperuricemia (AH) individuals and gout patients.
Methods
The V3–V4 region of the 16S rRNA gene of the gut microbiota of AH individuals, gout patients, and controls was sequenced. Bioinformatic analyses were carried out with QIIME2 and phyloseq to determine the difference in the relative abundance of bacterial genera among the study groups. Tax4fun2 was used to predict the functional profile of the gut microbiota.
Results
AH individuals presented a higher abundance of butyrate- and propionate-producing bacteria than gout patients; however, the latter had more bacteria capable of producing acetate. The abundance of
Prevotella
genus bacteria was not significantly different between the patients but was higher than that in controls. This result was corroborated by the functional profile, in which AH individuals had less pyruvate oxidase abundance than gout patients and less abundance of an enzyme that regulates glutamate synthetase activation than controls.
Conclusion
We observed a distinctive taxonomic profile in AH individuals characterized by a higher abundance of short-chain fatty acid-producing bacteria in comparison to those observed in gout patients. Furthermore, we provide scientific evidence that indicates that the gut microbiota of AH individuals could provide anti-inflammatory mediators, which prevent the appearance of gout flares.
Key Points
•
AH and gout patients both have a higher abundance of Prevotella genus bacteria than controls.
•
AH individuals’ gut microbiota had more butyrate- and propionate-producing bacteria than gout patients.
•
The gut microbiome of AH individuals provides anti-inflammatory mediators that could prevent gout flares.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-022-06392-9</identifier><identifier>PMID: 36201123</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abundance ; acetates ; Acetic acid ; Bacteria ; bioinformatics ; Fatty acids ; Genera ; genes ; glutamic acid ; Gout ; Hyperuricemia ; Inflammation ; Intestinal microflora ; intestinal microorganisms ; Medicine ; Medicine & Public Health ; Microbiomes ; Microbiota ; Original Article ; Prevotella ; Propionic acid ; Pyruvate oxidase ; Pyruvic acid ; Rheumatology ; rRNA 16S ; Taxonomy</subject><ispartof>Clinical rheumatology, 2023, Vol.42 (1), p.203-214</ispartof><rights>The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-5f0c9a1d8cb3812f8c1c24e5a59fef80720fdbf2ad060d191665a244f60227a23</citedby><cites>FETCH-LOGICAL-c408t-5f0c9a1d8cb3812f8c1c24e5a59fef80720fdbf2ad060d191665a244f60227a23</cites><orcidid>0000-0002-2575-2589</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-022-06392-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-022-06392-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36201123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martínez-Nava, Gabriela A.</creatorcontrib><creatorcontrib>Méndez-Salazar, Eder O.</creatorcontrib><creatorcontrib>Vázquez-Mellado, Janitzia</creatorcontrib><creatorcontrib>Zamudio-Cuevas, Yessica</creatorcontrib><creatorcontrib>Francisco-Balderas, Adriana</creatorcontrib><creatorcontrib>Martínez-Flores, Karina</creatorcontrib><creatorcontrib>Fernández-Torres, Javier</creatorcontrib><creatorcontrib>Lozada-Pérez, Carlos</creatorcontrib><creatorcontrib>Guido-Gómora, Dafne L.</creatorcontrib><creatorcontrib>Martínez-Gómez, Laura E.</creatorcontrib><creatorcontrib>Jiménez-Gutiérrez, Guadalupe E.</creatorcontrib><creatorcontrib>Pineda, Carlos</creatorcontrib><creatorcontrib>Silveira, Luis H.</creatorcontrib><creatorcontrib>Sánchez-Chapul, Laura</creatorcontrib><creatorcontrib>Sánchez-Sánchez, Roberto</creatorcontrib><creatorcontrib>Camacho-Rea, María del Carmen</creatorcontrib><creatorcontrib>Martínez-Armenta, Carlos</creatorcontrib><creatorcontrib>Burguete-García, Ana I.</creatorcontrib><creatorcontrib>Orbe-Orihuela, Citlalli</creatorcontrib><creatorcontrib>Lagunas-Martínez, Alfredo</creatorcontrib><creatorcontrib>Palacios-González, Berenice</creatorcontrib><creatorcontrib>López-Reyes, Alberto</creatorcontrib><title>The impact of short-chain fatty acid–producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Introduction/objectives
Persistent hyperuricemia is a key factor in gout; however, only 13.5% of hyperuricemic individuals manifest the disease. The gut microbiota could be one of the many factors underlying this phenomenon. We aimed to assess the difference in taxonomic and predicted functional profiles of the gut microbiota between asymptomatic hyperuricemia (AH) individuals and gout patients.
Methods
The V3–V4 region of the 16S rRNA gene of the gut microbiota of AH individuals, gout patients, and controls was sequenced. Bioinformatic analyses were carried out with QIIME2 and phyloseq to determine the difference in the relative abundance of bacterial genera among the study groups. Tax4fun2 was used to predict the functional profile of the gut microbiota.
Results
AH individuals presented a higher abundance of butyrate- and propionate-producing bacteria than gout patients; however, the latter had more bacteria capable of producing acetate. The abundance of
Prevotella
genus bacteria was not significantly different between the patients but was higher than that in controls. This result was corroborated by the functional profile, in which AH individuals had less pyruvate oxidase abundance than gout patients and less abundance of an enzyme that regulates glutamate synthetase activation than controls.
Conclusion
We observed a distinctive taxonomic profile in AH individuals characterized by a higher abundance of short-chain fatty acid-producing bacteria in comparison to those observed in gout patients. Furthermore, we provide scientific evidence that indicates that the gut microbiota of AH individuals could provide anti-inflammatory mediators, which prevent the appearance of gout flares.
Key Points
•
AH and gout patients both have a higher abundance of Prevotella genus bacteria than controls.
•
AH individuals’ gut microbiota had more butyrate- and propionate-producing bacteria than gout patients.
•
The gut microbiome of AH individuals provides anti-inflammatory mediators that could prevent gout flares.</description><subject>Abundance</subject><subject>acetates</subject><subject>Acetic acid</subject><subject>Bacteria</subject><subject>bioinformatics</subject><subject>Fatty acids</subject><subject>Genera</subject><subject>genes</subject><subject>glutamic acid</subject><subject>Gout</subject><subject>Hyperuricemia</subject><subject>Inflammation</subject><subject>Intestinal microflora</subject><subject>intestinal microorganisms</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Original Article</subject><subject>Prevotella</subject><subject>Propionic acid</subject><subject>Pyruvate oxidase</subject><subject>Pyruvic acid</subject><subject>Rheumatology</subject><subject>rRNA 16S</subject><subject>Taxonomy</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkbtuFDEUhi0EIpvAC1AgSzQ0huPLeuwSReEiRaIJteXxZdbRznixPcV2vEPekCfBYQNIFND4FP7-_1x-hF5QeEMBhre1v3IgwBgByTUj-hHaUMEF0Vrox2gDwwCEU63O0HmttwDAlKZP0RmXDChlfIPqzS7gNB-sazhHXHe5NOJ2Ni042taO2Lrkv3-7O5TsV5eWCY8dDSXZe7x18bQ2PCdX8phys7gLd8dDKGtJLswds4vHU-6QT3Zack31GXoS7b6G5w_1An15f3Vz-ZFcf_7w6fLdNXECVCPbCE5b6pUbuaIsKkcdE2FrtzqGqGBgEP0YmfUgwVNNpdxaJkSU_SKDZfwCvT759uG_rqE2M6fqwn5vl5DXaphSgwTNJP0_OjDGKadUdfTVX-htXsvSF-mUpKK7StEpdqL6YWotIZpDSbMtR0PB3KdnTumZPqv5mZ7RXfTywXod5-B_S37F1QF-Amr_WqZQ_vT-h-0Pjbml6g</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Martínez-Nava, Gabriela A.</creator><creator>Méndez-Salazar, Eder O.</creator><creator>Vázquez-Mellado, Janitzia</creator><creator>Zamudio-Cuevas, Yessica</creator><creator>Francisco-Balderas, Adriana</creator><creator>Martínez-Flores, Karina</creator><creator>Fernández-Torres, Javier</creator><creator>Lozada-Pérez, Carlos</creator><creator>Guido-Gómora, Dafne L.</creator><creator>Martínez-Gómez, Laura E.</creator><creator>Jiménez-Gutiérrez, Guadalupe E.</creator><creator>Pineda, Carlos</creator><creator>Silveira, Luis H.</creator><creator>Sánchez-Chapul, Laura</creator><creator>Sánchez-Sánchez, Roberto</creator><creator>Camacho-Rea, María del Carmen</creator><creator>Martínez-Armenta, Carlos</creator><creator>Burguete-García, Ana I.</creator><creator>Orbe-Orihuela, Citlalli</creator><creator>Lagunas-Martínez, Alfredo</creator><creator>Palacios-González, Berenice</creator><creator>López-Reyes, Alberto</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-2575-2589</orcidid></search><sort><creationdate>2023</creationdate><title>The impact of short-chain fatty acid–producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis</title><author>Martínez-Nava, Gabriela A. ; Méndez-Salazar, Eder O. ; Vázquez-Mellado, Janitzia ; Zamudio-Cuevas, Yessica ; Francisco-Balderas, Adriana ; Martínez-Flores, Karina ; Fernández-Torres, Javier ; Lozada-Pérez, Carlos ; Guido-Gómora, Dafne L. ; Martínez-Gómez, Laura E. ; Jiménez-Gutiérrez, Guadalupe E. ; Pineda, Carlos ; Silveira, Luis H. ; Sánchez-Chapul, Laura ; Sánchez-Sánchez, Roberto ; Camacho-Rea, María del Carmen ; Martínez-Armenta, Carlos ; Burguete-García, Ana I. ; Orbe-Orihuela, Citlalli ; Lagunas-Martínez, Alfredo ; Palacios-González, Berenice ; López-Reyes, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-5f0c9a1d8cb3812f8c1c24e5a59fef80720fdbf2ad060d191665a244f60227a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abundance</topic><topic>acetates</topic><topic>Acetic acid</topic><topic>Bacteria</topic><topic>bioinformatics</topic><topic>Fatty acids</topic><topic>Genera</topic><topic>genes</topic><topic>glutamic acid</topic><topic>Gout</topic><topic>Hyperuricemia</topic><topic>Inflammation</topic><topic>Intestinal microflora</topic><topic>intestinal microorganisms</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Original Article</topic><topic>Prevotella</topic><topic>Propionic acid</topic><topic>Pyruvate oxidase</topic><topic>Pyruvic acid</topic><topic>Rheumatology</topic><topic>rRNA 16S</topic><topic>Taxonomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martínez-Nava, Gabriela A.</creatorcontrib><creatorcontrib>Méndez-Salazar, Eder O.</creatorcontrib><creatorcontrib>Vázquez-Mellado, Janitzia</creatorcontrib><creatorcontrib>Zamudio-Cuevas, Yessica</creatorcontrib><creatorcontrib>Francisco-Balderas, Adriana</creatorcontrib><creatorcontrib>Martínez-Flores, Karina</creatorcontrib><creatorcontrib>Fernández-Torres, Javier</creatorcontrib><creatorcontrib>Lozada-Pérez, Carlos</creatorcontrib><creatorcontrib>Guido-Gómora, Dafne L.</creatorcontrib><creatorcontrib>Martínez-Gómez, Laura E.</creatorcontrib><creatorcontrib>Jiménez-Gutiérrez, Guadalupe E.</creatorcontrib><creatorcontrib>Pineda, Carlos</creatorcontrib><creatorcontrib>Silveira, Luis H.</creatorcontrib><creatorcontrib>Sánchez-Chapul, Laura</creatorcontrib><creatorcontrib>Sánchez-Sánchez, Roberto</creatorcontrib><creatorcontrib>Camacho-Rea, María del Carmen</creatorcontrib><creatorcontrib>Martínez-Armenta, Carlos</creatorcontrib><creatorcontrib>Burguete-García, Ana I.</creatorcontrib><creatorcontrib>Orbe-Orihuela, Citlalli</creatorcontrib><creatorcontrib>Lagunas-Martínez, Alfredo</creatorcontrib><creatorcontrib>Palacios-González, Berenice</creatorcontrib><creatorcontrib>López-Reyes, Alberto</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martínez-Nava, Gabriela A.</au><au>Méndez-Salazar, Eder O.</au><au>Vázquez-Mellado, Janitzia</au><au>Zamudio-Cuevas, Yessica</au><au>Francisco-Balderas, Adriana</au><au>Martínez-Flores, Karina</au><au>Fernández-Torres, Javier</au><au>Lozada-Pérez, Carlos</au><au>Guido-Gómora, Dafne L.</au><au>Martínez-Gómez, Laura E.</au><au>Jiménez-Gutiérrez, Guadalupe E.</au><au>Pineda, Carlos</au><au>Silveira, Luis H.</au><au>Sánchez-Chapul, Laura</au><au>Sánchez-Sánchez, Roberto</au><au>Camacho-Rea, María del Carmen</au><au>Martínez-Armenta, Carlos</au><au>Burguete-García, Ana I.</au><au>Orbe-Orihuela, Citlalli</au><au>Lagunas-Martínez, Alfredo</au><au>Palacios-González, Berenice</au><au>López-Reyes, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of short-chain fatty acid–producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2023</date><risdate>2023</risdate><volume>42</volume><issue>1</issue><spage>203</spage><epage>214</epage><pages>203-214</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Introduction/objectives
Persistent hyperuricemia is a key factor in gout; however, only 13.5% of hyperuricemic individuals manifest the disease. The gut microbiota could be one of the many factors underlying this phenomenon. We aimed to assess the difference in taxonomic and predicted functional profiles of the gut microbiota between asymptomatic hyperuricemia (AH) individuals and gout patients.
Methods
The V3–V4 region of the 16S rRNA gene of the gut microbiota of AH individuals, gout patients, and controls was sequenced. Bioinformatic analyses were carried out with QIIME2 and phyloseq to determine the difference in the relative abundance of bacterial genera among the study groups. Tax4fun2 was used to predict the functional profile of the gut microbiota.
Results
AH individuals presented a higher abundance of butyrate- and propionate-producing bacteria than gout patients; however, the latter had more bacteria capable of producing acetate. The abundance of
Prevotella
genus bacteria was not significantly different between the patients but was higher than that in controls. This result was corroborated by the functional profile, in which AH individuals had less pyruvate oxidase abundance than gout patients and less abundance of an enzyme that regulates glutamate synthetase activation than controls.
Conclusion
We observed a distinctive taxonomic profile in AH individuals characterized by a higher abundance of short-chain fatty acid-producing bacteria in comparison to those observed in gout patients. Furthermore, we provide scientific evidence that indicates that the gut microbiota of AH individuals could provide anti-inflammatory mediators, which prevent the appearance of gout flares.
Key Points
•
AH and gout patients both have a higher abundance of Prevotella genus bacteria than controls.
•
AH individuals’ gut microbiota had more butyrate- and propionate-producing bacteria than gout patients.
•
The gut microbiome of AH individuals provides anti-inflammatory mediators that could prevent gout flares.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36201123</pmid><doi>10.1007/s10067-022-06392-9</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-2575-2589</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0770-3198 |
| ispartof | Clinical rheumatology, 2023, Vol.42 (1), p.203-214 |
| issn | 0770-3198 1434-9949 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2887609261 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Abundance acetates Acetic acid Bacteria bioinformatics Fatty acids Genera genes glutamic acid Gout Hyperuricemia Inflammation Intestinal microflora intestinal microorganisms Medicine Medicine & Public Health Microbiomes Microbiota Original Article Prevotella Propionic acid Pyruvate oxidase Pyruvic acid Rheumatology rRNA 16S Taxonomy |
| title | The impact of short-chain fatty acid–producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis |
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