Spatial Transcriptomics Resolve an Emphysema-Specific Lymphoid Follicle B Cell Signature in Chronic Obstructive Pulmonary Disease

Within chronic obstructive pulmonary disease (COPD), emphysema is characterized by a significant yet partially understood B cell immune component. To characterize the transcriptomic signatures from lymphoid follicles (LFs) in ever-smokers without COPD and patients with COPD with varying degrees of e...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2024-01, Vol.209 (1), p.48-58
Hauptverfasser:	Rojas-Quintero, Joselyn, Ochsner, Scott A, New, Felicia, Divakar, Prajan, Yang, Chen Xi, Wu, Tianshi David, Robinson, Jerid, Chandrashekar, Darshan Shimoga, Banovich, Nicholas E, Rosas, Ivan O, Sauler, Maor, Kheradmand, Farrah, Gaggar, Amit, Margaroli, Camilla, San Jose Estepar, Raul, McKenna, Neil J, Polverino, Francesca
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronic obstructive pulmonary disease Emphysema Gene expression Gene Expression Profiling Humans Inflammation Lung diseases Lymphadenopathy Proteomics Pulmonary Disease, Chronic Obstructive Pulmonary Emphysema - diagnostic imaging Pulmonary Emphysema - genetics
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