tRNA‐derived fragments are altered in diabetes
Aims Maternally inherited diabetes and deafness (MIDD) is a rare form of adult‐onset diabetes that can be difficult to diagnose due to its variable clinical phenotype. Transfer RNA‐derived small fragments are a novel, emerging class of small non‐coding RNAs (sncRNAs) that have significant potential...
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| Veröffentlicht in: | Diabetic medicine 2024-02, Vol.41 (2), p.e15258-n/a |
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| container_title | Diabetic medicine |
| container_volume | 41 |
| creator | Ng, N. Gibriel, H. A. Y. Halang, L. Jirström, E. Ioana, J. A. Burke, M. Byrne, M. M. Prehn, J. H. M. |
| description | Aims
Maternally inherited diabetes and deafness (MIDD) is a rare form of adult‐onset diabetes that can be difficult to diagnose due to its variable clinical phenotype. Transfer RNA‐derived small fragments are a novel, emerging class of small non‐coding RNAs (sncRNAs) that have significant potential as serum biomarkers due to their stress‐induced generation, abundance, stability and ease of detection.
Methods
We investigated the levels of tiRNA 5'ValCAC (alone and in combination with miR‐23b‐3p) identified from small RNA sequencing studies in serum samples from healthy controls, type 1 diabetes, type 2 diabetes and MIDD subjects.
Results
Serum levels of 5'ValCAC were reduced in MIDD and type 2 diabetes subjects compared to controls. Type 2 diabetes subjects had higher serum levels of miR‐23b‐3p compared to all other subjects. Receiver Operating Characteristic analysis showed the potential of 5'ValCAC and miR‐23b‐3p as MIDD biomarkers, with the combination showing excellent separation from type 2 diabetes subjects.
Conclusions
This is the first report showing altered serum levels of tiRNAs in diabetes subjects. The combined use of 5'ValCAC and miR‐23b‐3p as serum biomarkers could potentially differentiate between MIDD subjects and type 2 diabetes subjects. |
| doi_str_mv | 10.1111/dme.15258 |
| format | Article |
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Maternally inherited diabetes and deafness (MIDD) is a rare form of adult‐onset diabetes that can be difficult to diagnose due to its variable clinical phenotype. Transfer RNA‐derived small fragments are a novel, emerging class of small non‐coding RNAs (sncRNAs) that have significant potential as serum biomarkers due to their stress‐induced generation, abundance, stability and ease of detection.
Methods
We investigated the levels of tiRNA 5'ValCAC (alone and in combination with miR‐23b‐3p) identified from small RNA sequencing studies in serum samples from healthy controls, type 1 diabetes, type 2 diabetes and MIDD subjects.
Results
Serum levels of 5'ValCAC were reduced in MIDD and type 2 diabetes subjects compared to controls. Type 2 diabetes subjects had higher serum levels of miR‐23b‐3p compared to all other subjects. Receiver Operating Characteristic analysis showed the potential of 5'ValCAC and miR‐23b‐3p as MIDD biomarkers, with the combination showing excellent separation from type 2 diabetes subjects.
Conclusions
This is the first report showing altered serum levels of tiRNAs in diabetes subjects. The combined use of 5'ValCAC and miR‐23b‐3p as serum biomarkers could potentially differentiate between MIDD subjects and type 2 diabetes subjects.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/dme.15258</identifier><identifier>PMID: 37935454</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; biomarker ; Biomarkers ; Deafness ; Diabetes ; Diabetes mellitus (insulin dependent) ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - genetics ; Humans ; maternally inherited diabetes and deafness ; MicroRNAs - genetics ; miRNA ; Mitochondrial Diseases ; Phenotypes ; RNA, Transfer ; Serum levels ; sncRNA ; tiRNA ; tRNA</subject><ispartof>Diabetic medicine, 2024-02, Vol.41 (2), p.e15258-n/a</ispartof><rights>2023 Diabetes UK.</rights><rights>Diabetic Medicine © 2024 Diabetes UK</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3138-3d959e70a7f421c22007d8e7371dc13f33709f35b65cd8e8ceb814a4e0801e013</cites><orcidid>0000-0002-9394-8698 ; 0000-0002-5355-8396 ; 0000-0002-3362-1570 ; 0000-0003-3479-7794 ; 0000-0003-4060-3300 ; 0000-0003-0076-672X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdme.15258$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdme.15258$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37935454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, N.</creatorcontrib><creatorcontrib>Gibriel, H. A. Y.</creatorcontrib><creatorcontrib>Halang, L.</creatorcontrib><creatorcontrib>Jirström, E.</creatorcontrib><creatorcontrib>Ioana, J. A.</creatorcontrib><creatorcontrib>Burke, M.</creatorcontrib><creatorcontrib>Byrne, M. M.</creatorcontrib><creatorcontrib>Prehn, J. H. M.</creatorcontrib><title>tRNA‐derived fragments are altered in diabetes</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims
Maternally inherited diabetes and deafness (MIDD) is a rare form of adult‐onset diabetes that can be difficult to diagnose due to its variable clinical phenotype. Transfer RNA‐derived small fragments are a novel, emerging class of small non‐coding RNAs (sncRNAs) that have significant potential as serum biomarkers due to their stress‐induced generation, abundance, stability and ease of detection.
Methods
We investigated the levels of tiRNA 5'ValCAC (alone and in combination with miR‐23b‐3p) identified from small RNA sequencing studies in serum samples from healthy controls, type 1 diabetes, type 2 diabetes and MIDD subjects.
Results
Serum levels of 5'ValCAC were reduced in MIDD and type 2 diabetes subjects compared to controls. Type 2 diabetes subjects had higher serum levels of miR‐23b‐3p compared to all other subjects. Receiver Operating Characteristic analysis showed the potential of 5'ValCAC and miR‐23b‐3p as MIDD biomarkers, with the combination showing excellent separation from type 2 diabetes subjects.
Conclusions
This is the first report showing altered serum levels of tiRNAs in diabetes subjects. The combined use of 5'ValCAC and miR‐23b‐3p as serum biomarkers could potentially differentiate between MIDD subjects and type 2 diabetes subjects.</description><subject>Adult</subject><subject>biomarker</subject><subject>Biomarkers</subject><subject>Deafness</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Humans</subject><subject>maternally inherited diabetes and deafness</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Mitochondrial Diseases</subject><subject>Phenotypes</subject><subject>RNA, Transfer</subject><subject>Serum levels</subject><subject>sncRNA</subject><subject>tiRNA</subject><subject>tRNA</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKw0AUQAdRbK0u_AEpuNFF7DwzM8tS6wOqguh6mCQ3kpJHnUmU7vwEv9EvcTTVheDdXLgcDpeD0CHBZyTMJKvgjAgq1BYaEh7zSHBNttEQS04jhiUZoD3vlxgTqpneRQMmNRNc8CHC7f3t9OPtPQNXvEA2zp19qqBu_dg6GNuyBReuRT3OCptAC34f7eS29HCw2SP0eDF_mF1Fi7vL69l0EaWMMBWxTAsNEluZc0pSSjGWmQLJJMlSwnLGJNY5E0ks0nBXKSSKcMsBK0wAEzZCJ7135ZrnDnxrqsKnUJa2hqbzhioluYwlFwE9_oMum87V4TtDNeE6VlTiQJ32VOoa7x3kZuWKyrq1Idh8ZTQho_nOGNijjbFLKsh-yZ9uAZj0wGtRwvp_kzm_mffKT6MYeaU</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Ng, N.</creator><creator>Gibriel, H. A. Y.</creator><creator>Halang, L.</creator><creator>Jirström, E.</creator><creator>Ioana, J. A.</creator><creator>Burke, M.</creator><creator>Byrne, M. M.</creator><creator>Prehn, J. H. M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9394-8698</orcidid><orcidid>https://orcid.org/0000-0002-5355-8396</orcidid><orcidid>https://orcid.org/0000-0002-3362-1570</orcidid><orcidid>https://orcid.org/0000-0003-3479-7794</orcidid><orcidid>https://orcid.org/0000-0003-4060-3300</orcidid><orcidid>https://orcid.org/0000-0003-0076-672X</orcidid></search><sort><creationdate>202402</creationdate><title>tRNA‐derived fragments are altered in diabetes</title><author>Ng, N. ; Gibriel, H. A. Y. ; Halang, L. ; Jirström, E. ; Ioana, J. A. ; Burke, M. ; Byrne, M. M. ; Prehn, J. H. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3138-3d959e70a7f421c22007d8e7371dc13f33709f35b65cd8e8ceb814a4e0801e013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>biomarker</topic><topic>Biomarkers</topic><topic>Deafness</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Humans</topic><topic>maternally inherited diabetes and deafness</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Mitochondrial Diseases</topic><topic>Phenotypes</topic><topic>RNA, Transfer</topic><topic>Serum levels</topic><topic>sncRNA</topic><topic>tiRNA</topic><topic>tRNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, N.</creatorcontrib><creatorcontrib>Gibriel, H. A. Y.</creatorcontrib><creatorcontrib>Halang, L.</creatorcontrib><creatorcontrib>Jirström, E.</creatorcontrib><creatorcontrib>Ioana, J. A.</creatorcontrib><creatorcontrib>Burke, M.</creatorcontrib><creatorcontrib>Byrne, M. M.</creatorcontrib><creatorcontrib>Prehn, J. H. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, N.</au><au>Gibriel, H. A. Y.</au><au>Halang, L.</au><au>Jirström, E.</au><au>Ioana, J. A.</au><au>Burke, M.</au><au>Byrne, M. M.</au><au>Prehn, J. H. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>tRNA‐derived fragments are altered in diabetes</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2024-02</date><risdate>2024</risdate><volume>41</volume><issue>2</issue><spage>e15258</spage><epage>n/a</epage><pages>e15258-n/a</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><abstract>Aims
Maternally inherited diabetes and deafness (MIDD) is a rare form of adult‐onset diabetes that can be difficult to diagnose due to its variable clinical phenotype. Transfer RNA‐derived small fragments are a novel, emerging class of small non‐coding RNAs (sncRNAs) that have significant potential as serum biomarkers due to their stress‐induced generation, abundance, stability and ease of detection.
Methods
We investigated the levels of tiRNA 5'ValCAC (alone and in combination with miR‐23b‐3p) identified from small RNA sequencing studies in serum samples from healthy controls, type 1 diabetes, type 2 diabetes and MIDD subjects.
Results
Serum levels of 5'ValCAC were reduced in MIDD and type 2 diabetes subjects compared to controls. Type 2 diabetes subjects had higher serum levels of miR‐23b‐3p compared to all other subjects. Receiver Operating Characteristic analysis showed the potential of 5'ValCAC and miR‐23b‐3p as MIDD biomarkers, with the combination showing excellent separation from type 2 diabetes subjects.
Conclusions
This is the first report showing altered serum levels of tiRNAs in diabetes subjects. The combined use of 5'ValCAC and miR‐23b‐3p as serum biomarkers could potentially differentiate between MIDD subjects and type 2 diabetes subjects.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37935454</pmid><doi>10.1111/dme.15258</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9394-8698</orcidid><orcidid>https://orcid.org/0000-0002-5355-8396</orcidid><orcidid>https://orcid.org/0000-0002-3362-1570</orcidid><orcidid>https://orcid.org/0000-0003-3479-7794</orcidid><orcidid>https://orcid.org/0000-0003-4060-3300</orcidid><orcidid>https://orcid.org/0000-0003-0076-672X</orcidid></addata></record> |
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| ispartof | Diabetic medicine, 2024-02, Vol.41 (2), p.e15258-n/a |
| issn | 0742-3071 1464-5491 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult biomarker Biomarkers Deafness Diabetes Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Humans maternally inherited diabetes and deafness MicroRNAs - genetics miRNA Mitochondrial Diseases Phenotypes RNA, Transfer Serum levels sncRNA tiRNA tRNA |
| title | tRNA‐derived fragments are altered in diabetes |
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