Opportunities and Challenges for a Histology-Agnostic Utilization of Trastuzumab Deruxtecan

Purpose of Review This review delves into the prospects and challenges offered by a potential pan-histological utilization of trastuzumab deruxtecan (T-DXd) in patients with advanced solid tumors. Recent Findings The HER2-targeted antibody-drug conjugate (ADC) T-DXd has shown broad activity across c...

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Veröffentlicht in:	Current oncology reports 2023-12, Vol.25 (12), p.1467-1482
Hauptverfasser:	Neupane, Niraj, Thapa, Sangharsha, Bhattarai, Abhinav, Ahuja, Kriti, Schlam, Ilana, Mittal, Abhenil, Tolaney, Sara M., Tarantino, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Biomarkers Breast Breast Neoplasms - drug therapy Camptothecin Cancer Vaccines Carcinoma, Non-Small-Cell Lung Chemotherapy Clinical trials Cytotoxicity ErbB-2 protein Female Histology Humans Immunoconjugates - therapeutic use Immunotherapy Lung cancer Lung Neoplasms Medicine Medicine & Public Health Monoclonal antibodies Non-small cell lung carcinoma Oncology Receptor, ErbB-2 Solid tumors Targeted cancer therapy Topical Collection on Evolving Therapies Trastuzumab Trastuzumab - therapeutic use
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