Adjuvant Radiotherapy in Moderately Advanced (T3) Oral Cavity Cancers

Objective To investigate the impact of adjuvant radiotherapy in isolated locally advanced oral cavity cancers (pT3N0M0) without adverse features. Methods We selected all patients from the National Cancer Database (2004–2019) who underwent surgical treatment where the final pathology was T3N0M0 with negative margins. Demographics, details of treatment, and outcomes were ed. The impact of radiotherapy on survival was assessed with univariable, multivariable, and propensity score‐matched analyses. Results We identified 571 patients in our survival cohort. Most were male (348, 60.9%), and median age was 65. Less than one‐third (176, 30.8%) received adjuvant radiotherapy. The median length of follow‐up was 29 months. Overall, adjuvant radiotherapy was associated with improved survival (87.2% vs. 77.7%, at 2 years, p