Selective Venous Sampling Prompting Unilateral Oophorectomy in an Adolescent With PCOS and Markedly Elevated Testosterone

Selective Venous Sampling Prompting Unilateral Oophorectomy in an Adolescent With PCOS and Markedly Elevated Testosterone

BACKGROUNDFor adolescents with suspected polycystic ovary syndrome (PCOS) and severely elevated testosterone concentrations, imaging is recommended to assess for neoplasm. Selective venous sampling (SVS) can be considered when imaging is nondiagnostic.CASEAn adolescent female treated for PCOS had a...

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Veröffentlicht in:Journal of pediatric and adolescent gynecology 2023, Vol.36 (2), p.103-106
Hauptverfasser: Halpin, Kelsee, Paprocki, Emily, Eickhoff, Paige, Rivard, Douglas C, Habeebu, Sahibu Sultan, Priebe, Anne-Marie
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container_end_page 106
container_issue 2
container_start_page 103
container_title Journal of pediatric and adolescent gynecology
container_volume 36
creator Halpin, Kelsee
Paprocki, Emily
Eickhoff, Paige
Rivard, Douglas C
Habeebu, Sahibu Sultan
Priebe, Anne-Marie
description BACKGROUNDFor adolescents with suspected polycystic ovary syndrome (PCOS) and severely elevated testosterone concentrations, imaging is recommended to assess for neoplasm. Selective venous sampling (SVS) can be considered when imaging is nondiagnostic.CASEAn adolescent female treated for PCOS had a peak testosterone of 344 ng/dL (11.9 nmol/L). Imaging did not localize a mass. SVS implicated the right ovary as the source of hyperandrogenism. Following laparoscopic right oophorectomy, pathology excluded a neoplasm and confirmed PCOS. She subsequently had rapid and persistent improvement in her hyperandrogenism.SUMMARY AND CONCLUSIONStriking testosterone elevation can occur with adolescent PCOS. SVS is a tool for localizing the source of severe hyperandrogenism, yet unilaterality is not always diagnostic of a neoplasm. Unilateral oophorectomy could nonetheless be therapeutic for severe PCOS.
doi_str_mv 10.1016/j.jpag.2022.10.006
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Selective venous sampling (SVS) can be considered when imaging is nondiagnostic.CASEAn adolescent female treated for PCOS had a peak testosterone of 344 ng/dL (11.9 nmol/L). Imaging did not localize a mass. SVS implicated the right ovary as the source of hyperandrogenism. Following laparoscopic right oophorectomy, pathology excluded a neoplasm and confirmed PCOS. She subsequently had rapid and persistent improvement in her hyperandrogenism.SUMMARY AND CONCLUSIONStriking testosterone elevation can occur with adolescent PCOS. SVS is a tool for localizing the source of severe hyperandrogenism, yet unilaterality is not always diagnostic of a neoplasm. 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Selective venous sampling (SVS) can be considered when imaging is nondiagnostic.CASEAn adolescent female treated for PCOS had a peak testosterone of 344 ng/dL (11.9 nmol/L). Imaging did not localize a mass. SVS implicated the right ovary as the source of hyperandrogenism. Following laparoscopic right oophorectomy, pathology excluded a neoplasm and confirmed PCOS. She subsequently had rapid and persistent improvement in her hyperandrogenism.SUMMARY AND CONCLUSIONStriking testosterone elevation can occur with adolescent PCOS. SVS is a tool for localizing the source of severe hyperandrogenism, yet unilaterality is not always diagnostic of a neoplasm. Unilateral oophorectomy could nonetheless be therapeutic for severe PCOS.</abstract><doi>10.1016/j.jpag.2022.10.006</doi></addata></record>
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title Selective Venous Sampling Prompting Unilateral Oophorectomy in an Adolescent With PCOS and Markedly Elevated Testosterone
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