Human peripheral blood mononuclear cells as a valuable source of disease‐related biomarkers: Evidence from comparative proteomics studies
Purpose The discovery of specific and sensitive disease‐associated biomarkers for early diagnostic purposes of many diseases is still highly challenging due to various complex molecular mechanisms triggered, high variability of disease‐related interactions, and an overlap of manifestations among dis...
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| Veröffentlicht in: | Proteomics. Clinical applications 2024-03, Vol.18 (2), p.e2300072-n/a |
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| container_title | Proteomics. Clinical applications |
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| creator | Alexovič, Michal Uličná, Csilla Sabo, Ján Davalieva, Katarina |
| description | Purpose
The discovery of specific and sensitive disease‐associated biomarkers for early diagnostic purposes of many diseases is still highly challenging due to various complex molecular mechanisms triggered, high variability of disease‐related interactions, and an overlap of manifestations among diseases. Human peripheral blood mononuclear cells (PBMCs) contain protein signatures corresponding to essential immunological interplay. Certain diseases stimulate PBMCs and contribute towards modulation of their proteome which can be effectively identified and evaluated via the comparative proteomics approach.
Experimental design
In this review, we made a detailed survey of the PBMCS‐derived protein biomarker candidates for a variety of diseases, published in the last 15 years. Articles were preselected to include only comparative proteomics studies.
Results
PBMC‐derived biomarkers were investigated for cancer, glomerular, neurodegenerative/neurodevelopmental, psychiatric, chronic inflammatory, autoimmune, endocrinal, infectious, and other diseases. A detailed review of these studies encompassed the proteomics platforms, proposed candidate biomarkers, their immune cell type specificity, and potential clinical application.
Conclusions
Overall, PBMCs have shown a solid potential in giving early diagnostic and prognostic biomarkers for many diseases. The future of PBMC biomarker research should reveal its full potential through well‐designed comparative studies and extensive testing of the most promising protein biomarkers identified so far. |
| doi_str_mv | 10.1002/prca.202300072 |
| format | Article |
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The discovery of specific and sensitive disease‐associated biomarkers for early diagnostic purposes of many diseases is still highly challenging due to various complex molecular mechanisms triggered, high variability of disease‐related interactions, and an overlap of manifestations among diseases. Human peripheral blood mononuclear cells (PBMCs) contain protein signatures corresponding to essential immunological interplay. Certain diseases stimulate PBMCs and contribute towards modulation of their proteome which can be effectively identified and evaluated via the comparative proteomics approach.
Experimental design
In this review, we made a detailed survey of the PBMCS‐derived protein biomarker candidates for a variety of diseases, published in the last 15 years. Articles were preselected to include only comparative proteomics studies.
Results
PBMC‐derived biomarkers were investigated for cancer, glomerular, neurodegenerative/neurodevelopmental, psychiatric, chronic inflammatory, autoimmune, endocrinal, infectious, and other diseases. A detailed review of these studies encompassed the proteomics platforms, proposed candidate biomarkers, their immune cell type specificity, and potential clinical application.
Conclusions
Overall, PBMCs have shown a solid potential in giving early diagnostic and prognostic biomarkers for many diseases. The future of PBMC biomarker research should reveal its full potential through well‐designed comparative studies and extensive testing of the most promising protein biomarkers identified so far.</description><identifier>ISSN: 1862-8346</identifier><identifier>EISSN: 1862-8354</identifier><identifier>DOI: 10.1002/prca.202300072</identifier><identifier>PMID: 37933719</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>biomarker ; Biomarkers ; Blood ; comparative proteomics ; Comparative studies ; Design of experiments ; Disease ; Immune system ; Immunology ; Inflammation ; Leukocytes (mononuclear) ; Molecular modelling ; Peripheral blood mononuclear cells ; Proteins ; Proteomes ; Proteomics</subject><ispartof>Proteomics. Clinical applications, 2024-03, Vol.18 (2), p.e2300072-n/a</ispartof><rights>2023 Wiley‐VCH GmbH.</rights><rights>2023 Wiley-VCH GmbH.</rights><rights>2024 Wiley‐VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3688-8ba5e5ec71f0e804d276f37438d5281decb4909c35a69f1e6e7251979e613b7b3</citedby><cites>FETCH-LOGICAL-c3688-8ba5e5ec71f0e804d276f37438d5281decb4909c35a69f1e6e7251979e613b7b3</cites><orcidid>0000-0002-0878-6533</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fprca.202300072$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fprca.202300072$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37933719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexovič, Michal</creatorcontrib><creatorcontrib>Uličná, Csilla</creatorcontrib><creatorcontrib>Sabo, Ján</creatorcontrib><creatorcontrib>Davalieva, Katarina</creatorcontrib><title>Human peripheral blood mononuclear cells as a valuable source of disease‐related biomarkers: Evidence from comparative proteomics studies</title><title>Proteomics. Clinical applications</title><addtitle>Proteomics Clin Appl</addtitle><description>Purpose
The discovery of specific and sensitive disease‐associated biomarkers for early diagnostic purposes of many diseases is still highly challenging due to various complex molecular mechanisms triggered, high variability of disease‐related interactions, and an overlap of manifestations among diseases. Human peripheral blood mononuclear cells (PBMCs) contain protein signatures corresponding to essential immunological interplay. Certain diseases stimulate PBMCs and contribute towards modulation of their proteome which can be effectively identified and evaluated via the comparative proteomics approach.
Experimental design
In this review, we made a detailed survey of the PBMCS‐derived protein biomarker candidates for a variety of diseases, published in the last 15 years. Articles were preselected to include only comparative proteomics studies.
Results
PBMC‐derived biomarkers were investigated for cancer, glomerular, neurodegenerative/neurodevelopmental, psychiatric, chronic inflammatory, autoimmune, endocrinal, infectious, and other diseases. A detailed review of these studies encompassed the proteomics platforms, proposed candidate biomarkers, their immune cell type specificity, and potential clinical application.
Conclusions
Overall, PBMCs have shown a solid potential in giving early diagnostic and prognostic biomarkers for many diseases. The future of PBMC biomarker research should reveal its full potential through well‐designed comparative studies and extensive testing of the most promising protein biomarkers identified so far.</description><subject>biomarker</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>comparative proteomics</subject><subject>Comparative studies</subject><subject>Design of experiments</subject><subject>Disease</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Leukocytes (mononuclear)</subject><subject>Molecular modelling</subject><subject>Peripheral blood mononuclear cells</subject><subject>Proteins</subject><subject>Proteomes</subject><subject>Proteomics</subject><issn>1862-8346</issn><issn>1862-8354</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkT1vFDEQhi0EIh_QUiJLNDR38df6gy46hQQpUhCC2vJ6Z4WDd73Yuxelo6fhN-aXxKcLV9AgjTRTPPNq3nkRekPJmhLCzqbs3ZoRxgkhij1Dx1RLttK8Ec8Ps5BH6KSUW0IawRR5iY64Mpwrao7R76tlcCOeIIfpO2QXcRtT6vCQxjQuPoLL2EOMBbtaeOvi4toIuKQle8Cpx10o4Ao8_PqTIboZOtyGNLj8A3L5gC-2oYOxkn1OA_ZpmFx2c9gCnnKaIQ3BF1zmpQtQXqEXvYsFXj_1U_Tt48XXzdXq-uby0-b8euW51HqlW9dAA17RnoAmomNK9lwJrruGadqBb4UhxvPGSdNTkKBYQ40yIClvVctP0fu9bj3h5wJltkMoO5NuhLQUy7SWRjBGdUXf_YPeVuNjvc4y0wjZEK5kpdZ7yudUSobeTjnUF9xbSuwuJruLyR5iqgtvn2SXdoDugP_NpQJiD9yFCPf_kbOfv2zOGVOaPwLuNqDu</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Alexovič, Michal</creator><creator>Uličná, Csilla</creator><creator>Sabo, Ján</creator><creator>Davalieva, Katarina</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0878-6533</orcidid></search><sort><creationdate>202403</creationdate><title>Human peripheral blood mononuclear cells as a valuable source of disease‐related biomarkers: Evidence from comparative proteomics studies</title><author>Alexovič, Michal ; Uličná, Csilla ; Sabo, Ján ; Davalieva, Katarina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3688-8ba5e5ec71f0e804d276f37438d5281decb4909c35a69f1e6e7251979e613b7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>biomarker</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>comparative proteomics</topic><topic>Comparative studies</topic><topic>Design of experiments</topic><topic>Disease</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Leukocytes (mononuclear)</topic><topic>Molecular modelling</topic><topic>Peripheral blood mononuclear cells</topic><topic>Proteins</topic><topic>Proteomes</topic><topic>Proteomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexovič, Michal</creatorcontrib><creatorcontrib>Uličná, Csilla</creatorcontrib><creatorcontrib>Sabo, Ján</creatorcontrib><creatorcontrib>Davalieva, Katarina</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Proteomics. Clinical applications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexovič, Michal</au><au>Uličná, Csilla</au><au>Sabo, Ján</au><au>Davalieva, Katarina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human peripheral blood mononuclear cells as a valuable source of disease‐related biomarkers: Evidence from comparative proteomics studies</atitle><jtitle>Proteomics. Clinical applications</jtitle><addtitle>Proteomics Clin Appl</addtitle><date>2024-03</date><risdate>2024</risdate><volume>18</volume><issue>2</issue><spage>e2300072</spage><epage>n/a</epage><pages>e2300072-n/a</pages><issn>1862-8346</issn><eissn>1862-8354</eissn><abstract>Purpose
The discovery of specific and sensitive disease‐associated biomarkers for early diagnostic purposes of many diseases is still highly challenging due to various complex molecular mechanisms triggered, high variability of disease‐related interactions, and an overlap of manifestations among diseases. Human peripheral blood mononuclear cells (PBMCs) contain protein signatures corresponding to essential immunological interplay. Certain diseases stimulate PBMCs and contribute towards modulation of their proteome which can be effectively identified and evaluated via the comparative proteomics approach.
Experimental design
In this review, we made a detailed survey of the PBMCS‐derived protein biomarker candidates for a variety of diseases, published in the last 15 years. Articles were preselected to include only comparative proteomics studies.
Results
PBMC‐derived biomarkers were investigated for cancer, glomerular, neurodegenerative/neurodevelopmental, psychiatric, chronic inflammatory, autoimmune, endocrinal, infectious, and other diseases. A detailed review of these studies encompassed the proteomics platforms, proposed candidate biomarkers, their immune cell type specificity, and potential clinical application.
Conclusions
Overall, PBMCs have shown a solid potential in giving early diagnostic and prognostic biomarkers for many diseases. The future of PBMC biomarker research should reveal its full potential through well‐designed comparative studies and extensive testing of the most promising protein biomarkers identified so far.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37933719</pmid><doi>10.1002/prca.202300072</doi><tpages>41</tpages><orcidid>https://orcid.org/0000-0002-0878-6533</orcidid></addata></record> |
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| subjects | biomarker Biomarkers Blood comparative proteomics Comparative studies Design of experiments Disease Immune system Immunology Inflammation Leukocytes (mononuclear) Molecular modelling Peripheral blood mononuclear cells Proteins Proteomes Proteomics |
| title | Human peripheral blood mononuclear cells as a valuable source of disease‐related biomarkers: Evidence from comparative proteomics studies |
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