Humanin ameliorates TBI-related cognitive impairment by attenuating mitochondrial dysfunction and inflammation

Traumatic brain injury (TBI) often results in a reduction of the capacity of cells to sustain energy demands, thus, compromising neuronal function and plasticity. Here we show that the mitochondrial activator humanin (HN) counteracts a TBI-related reduction in mitochondrial bioenergetics, including...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2024-02, Vol.1870 (2), p.166937-166937, Article 166937
Hauptverfasser:	Thapak, Pavan, Ying, Zhe, Palafox-Sanchez, Victoria, Zhang, Guanglin, Yang, Xia, Gomez-Pinilla, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins Brain Injuries, Traumatic - complications Brain Injuries, Traumatic - drug therapy Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Inflammation - drug therapy Mitochondrial Diseases Rats Rats, Sprague-Dawley
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