The microRNA-195-5p/hnRNP A1 axis contributes to the progression of hepatocellular carcinoma by regulating the migration of cancer cells
Dysregulation of gene expression is critical for the progression of cancer. The augmented expression of hnRNP A1 in patients with hepatocellular carcinoma (HCC) has been related to its oncogenic functions. However, the underlying mechanisms responsible for upregulation of hnRNP A1 have not been full...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2023-12, Vol.686, p.149183-149183, Article 149183 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Jung, Myeongwoo Ji, Eunbyul Kang, Hoin Kim, Chongtae Ryu, Seungyeon Han, Sukyoung Cha, Seongho Lee, Eun Kyung |
| description | Dysregulation of gene expression is critical for the progression of cancer. The augmented expression of hnRNP A1 in patients with hepatocellular carcinoma (HCC) has been related to its oncogenic functions. However, the underlying mechanisms responsible for upregulation of hnRNP A1 have not been fully elucidated. In the present study, we identified microRNA-195-5p (miR-195-5p), a miRNA downregulated in HCC, as a novel regulator governing hnRNP A1 expression. Notably, our investigations showed an inverse correlation between hnRNP A1 level, which was increased in HCC, and miR-195-5p level, which was decreased. Our findings demonstrated that hnRNP A1 significantly enhanced the migration and invasion of PLC/PRF/5 cells through its association with mRNAs regulating metastasis. MiR-195-5p also interfered with the hnRNP A1-mediated cell migration by targeting hnRNP A1. Our results underscore the significance of the miR-195-5p/hnRNP A1 axis in regulating the migratory potential of cancer cells and its role in promoting HCC by orchestrating cell migration processes. |
| doi_str_mv | 10.1016/j.bbrc.2023.149183 |
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The augmented expression of hnRNP A1 in patients with hepatocellular carcinoma (HCC) has been related to its oncogenic functions. However, the underlying mechanisms responsible for upregulation of hnRNP A1 have not been fully elucidated. In the present study, we identified microRNA-195-5p (miR-195-5p), a miRNA downregulated in HCC, as a novel regulator governing hnRNP A1 expression. Notably, our investigations showed an inverse correlation between hnRNP A1 level, which was increased in HCC, and miR-195-5p level, which was decreased. Our findings demonstrated that hnRNP A1 significantly enhanced the migration and invasion of PLC/PRF/5 cells through its association with mRNAs regulating metastasis. MiR-195-5p also interfered with the hnRNP A1-mediated cell migration by targeting hnRNP A1. Our results underscore the significance of the miR-195-5p/hnRNP A1 axis in regulating the migratory potential of cancer cells and its role in promoting HCC by orchestrating cell migration processes.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2023.149183</identifier><identifier>PMID: 37926044</identifier><language>eng</language><publisher>United States</publisher><subject>Carcinoma, Hepatocellular - pathology ; Cell Line, Tumor ; Cell Movement - genetics ; Cell Proliferation - genetics ; Gene Expression Regulation, Neoplastic ; Heterogeneous Nuclear Ribonucleoprotein A1 - genetics ; Heterogeneous Nuclear Ribonucleoprotein A1 - metabolism ; Humans ; Liver Neoplasms - pathology ; MicroRNAs - genetics ; MicroRNAs - metabolism</subject><ispartof>Biochemical and biophysical research communications, 2023-12, Vol.686, p.149183-149183, Article 149183</ispartof><rights>Copyright © 2023 Elsevier Inc. 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The augmented expression of hnRNP A1 in patients with hepatocellular carcinoma (HCC) has been related to its oncogenic functions. However, the underlying mechanisms responsible for upregulation of hnRNP A1 have not been fully elucidated. In the present study, we identified microRNA-195-5p (miR-195-5p), a miRNA downregulated in HCC, as a novel regulator governing hnRNP A1 expression. Notably, our investigations showed an inverse correlation between hnRNP A1 level, which was increased in HCC, and miR-195-5p level, which was decreased. Our findings demonstrated that hnRNP A1 significantly enhanced the migration and invasion of PLC/PRF/5 cells through its association with mRNAs regulating metastasis. MiR-195-5p also interfered with the hnRNP A1-mediated cell migration by targeting hnRNP A1. Our results underscore the significance of the miR-195-5p/hnRNP A1 axis in regulating the migratory potential of cancer cells and its role in promoting HCC by orchestrating cell migration processes.</description><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Heterogeneous Nuclear Ribonucleoprotein A1 - genetics</subject><subject>Heterogeneous Nuclear Ribonucleoprotein A1 - metabolism</subject><subject>Humans</subject><subject>Liver Neoplasms - pathology</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctOwzAQRS0EgvL4ARbISzYpfsbxskK8JAQIgcTOcpxJ66qJi51I8Ad8Ni4FVqMZ3TOauRehU0qmlNDyYjmt6-imjDA-pULTiu-gCSWaFIwSsYsmhJCyYJq-HaDDlJaEUCpKvY8OuNKsJEJM0NfLAnDnXQzPD7OCalnI9cWif354wjOK7YdP2IV-iL4eB0h4CHjIwDqGeYSUfOhxaPEC1nYIDlarcWUjdjY634fO4voTR5jn4eD7-Q_Z-XnM3ZZztneQ9RlMx2ivtasEJ7_1CL1eX71c3hb3jzd3l7P7wnHCh6KRylWOcGp13chaSAGt4AQappRsNWuoY9ZyJTUHWXEKWtVc8JI1rRIaLD9C59u9-Yf3EdJgOp82F9gewpgMq6pSaqVLlaVsK83upBShNevoOxs_DSVmk4BZmk0CZpOA2SaQobPf_WPdQfOP_FnOvwFmAYOo</recordid><startdate>20231217</startdate><enddate>20231217</enddate><creator>Jung, Myeongwoo</creator><creator>Ji, Eunbyul</creator><creator>Kang, Hoin</creator><creator>Kim, Chongtae</creator><creator>Ryu, Seungyeon</creator><creator>Han, Sukyoung</creator><creator>Cha, Seongho</creator><creator>Lee, Eun Kyung</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20231217</creationdate><title>The microRNA-195-5p/hnRNP A1 axis contributes to the progression of hepatocellular carcinoma by regulating the migration of cancer cells</title><author>Jung, Myeongwoo ; Ji, Eunbyul ; Kang, Hoin ; Kim, Chongtae ; Ryu, Seungyeon ; Han, Sukyoung ; Cha, Seongho ; Lee, Eun Kyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-d57c8c031a9bd5b454ef430ed2775f92d1c2aa37593e5831e97b34362df749ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>Cell Proliferation - genetics</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Heterogeneous Nuclear Ribonucleoprotein A1 - genetics</topic><topic>Heterogeneous Nuclear Ribonucleoprotein A1 - metabolism</topic><topic>Humans</topic><topic>Liver Neoplasms - pathology</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Myeongwoo</creatorcontrib><creatorcontrib>Ji, Eunbyul</creatorcontrib><creatorcontrib>Kang, Hoin</creatorcontrib><creatorcontrib>Kim, Chongtae</creatorcontrib><creatorcontrib>Ryu, Seungyeon</creatorcontrib><creatorcontrib>Han, Sukyoung</creatorcontrib><creatorcontrib>Cha, Seongho</creatorcontrib><creatorcontrib>Lee, Eun Kyung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Myeongwoo</au><au>Ji, Eunbyul</au><au>Kang, Hoin</au><au>Kim, Chongtae</au><au>Ryu, Seungyeon</au><au>Han, Sukyoung</au><au>Cha, Seongho</au><au>Lee, Eun Kyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The microRNA-195-5p/hnRNP A1 axis contributes to the progression of hepatocellular carcinoma by regulating the migration of cancer cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2023-12-17</date><risdate>2023</risdate><volume>686</volume><spage>149183</spage><epage>149183</epage><pages>149183-149183</pages><artnum>149183</artnum><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Dysregulation of gene expression is critical for the progression of cancer. The augmented expression of hnRNP A1 in patients with hepatocellular carcinoma (HCC) has been related to its oncogenic functions. However, the underlying mechanisms responsible for upregulation of hnRNP A1 have not been fully elucidated. In the present study, we identified microRNA-195-5p (miR-195-5p), a miRNA downregulated in HCC, as a novel regulator governing hnRNP A1 expression. Notably, our investigations showed an inverse correlation between hnRNP A1 level, which was increased in HCC, and miR-195-5p level, which was decreased. Our findings demonstrated that hnRNP A1 significantly enhanced the migration and invasion of PLC/PRF/5 cells through its association with mRNAs regulating metastasis. MiR-195-5p also interfered with the hnRNP A1-mediated cell migration by targeting hnRNP A1. Our results underscore the significance of the miR-195-5p/hnRNP A1 axis in regulating the migratory potential of cancer cells and its role in promoting HCC by orchestrating cell migration processes.</abstract><cop>United States</cop><pmid>37926044</pmid><doi>10.1016/j.bbrc.2023.149183</doi><tpages>1</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Gene Expression Regulation, Neoplastic Heterogeneous Nuclear Ribonucleoprotein A1 - genetics Heterogeneous Nuclear Ribonucleoprotein A1 - metabolism Humans Liver Neoplasms - pathology MicroRNAs - genetics MicroRNAs - metabolism |
| title | The microRNA-195-5p/hnRNP A1 axis contributes to the progression of hepatocellular carcinoma by regulating the migration of cancer cells |
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