Biopolymer‐Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing
Hydrogels are considered as a promising medical patch for wound healing. Researches in this aspect are focused on improving their compositions and permeability to enhance the effectiveness of wound healing. Here, novel prolamins‐assembled porous hydrogel microfibers with the desired merits for treat...
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| Veröffentlicht in: | Advanced healthcare materials 2024-01, Vol.13 (3), p.e2302170-n/a |
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| creator | Wang, Yu Guo, Jiahui Luo, Zhiqiang Shen, Yingbo Wang, Jinglin Yu, Yunru Zhao, Yuanjin |
| description | Hydrogels are considered as a promising medical patch for wound healing. Researches in this aspect are focused on improving their compositions and permeability to enhance the effectiveness of wound healing. Here, novel prolamins‐assembled porous hydrogel microfibers with the desired merits for treating diabetes wounds are presented. Such microfibers are continuously generated by one‐step microfluidic spinning technology with acetic acid solution of prolamins as the continuous phase and deionized water as the dispersed phase. By adjusting the prolamin concentration and flow rates of microfluidics, the porous structure and morphology as well as diameters of microfibers can be well tailored. Owing to their porosity, the resultant microfibers can be employed as flexible delivery systems for wound healing actives, such as bacitracin and vascular endothelial growth factor (VEGF). It is demonstrated that the resultant hydrogel microfibers are with good cell‐affinity and effective drug release efficiency, and their woven patches display superior in vivo capability in treating diabetes wounds. Thus, it is believed that the proposed prolamins‐assembled porous hydrogel microfibers will show important values in clinic wound treatments.
Novel prolamins‐assembled porous hydrogel microfibers generated from microfluidic spinning technology for wound healing are presented. The resultant microfibers possess porous structure and could be served as the drug‐loaded carrier. The drug‐loaded microfibers show good cell‐affinity and effective drug release efficiency, which have potential values in wound disease treatment. |
| doi_str_mv | 10.1002/adhm.202302170 |
| format | Article |
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Novel prolamins‐assembled porous hydrogel microfibers generated from microfluidic spinning technology for wound healing are presented. The resultant microfibers possess porous structure and could be served as the drug‐loaded carrier. The drug‐loaded microfibers show good cell‐affinity and effective drug release efficiency, which have potential values in wound disease treatment.</description><identifier>ISSN: 2192-2640</identifier><identifier>ISSN: 2192-2659</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202302170</identifier><identifier>PMID: 37921989</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Acetic acid ; Bacitracin ; Biocompatible Materials - chemistry ; Biopolymers ; Deionization ; Diabetes ; Diabetes Mellitus ; Drug delivery systems ; drug release ; Growth factors ; Humans ; Hydrogels ; Hydrogels - chemistry ; Hydrogels - pharmacology ; Microfibers ; Microfluidics ; Microfluidics - methods ; Permeability ; Porosity ; porous ; prolamin ; Prolamines ; Prolamins - pharmacology ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - pharmacology ; Wound Healing</subject><ispartof>Advanced healthcare materials, 2024-01, Vol.13 (3), p.e2302170-n/a</ispartof><rights>2023 Wiley‐VCH GmbH</rights><rights>2023 Wiley-VCH GmbH.</rights><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3730-b5e90e710ff79fc8ba0cf41b0952ffb51d401e6e2ae353b4ebece1f6ea99bfe33</citedby><cites>FETCH-LOGICAL-c3730-b5e90e710ff79fc8ba0cf41b0952ffb51d401e6e2ae353b4ebece1f6ea99bfe33</cites><orcidid>0000-0001-9242-4000</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202302170$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202302170$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37921989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Guo, Jiahui</creatorcontrib><creatorcontrib>Luo, Zhiqiang</creatorcontrib><creatorcontrib>Shen, Yingbo</creatorcontrib><creatorcontrib>Wang, Jinglin</creatorcontrib><creatorcontrib>Yu, Yunru</creatorcontrib><creatorcontrib>Zhao, Yuanjin</creatorcontrib><title>Biopolymer‐Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Hydrogels are considered as a promising medical patch for wound healing. Researches in this aspect are focused on improving their compositions and permeability to enhance the effectiveness of wound healing. Here, novel prolamins‐assembled porous hydrogel microfibers with the desired merits for treating diabetes wounds are presented. Such microfibers are continuously generated by one‐step microfluidic spinning technology with acetic acid solution of prolamins as the continuous phase and deionized water as the dispersed phase. By adjusting the prolamin concentration and flow rates of microfluidics, the porous structure and morphology as well as diameters of microfibers can be well tailored. Owing to their porosity, the resultant microfibers can be employed as flexible delivery systems for wound healing actives, such as bacitracin and vascular endothelial growth factor (VEGF). It is demonstrated that the resultant hydrogel microfibers are with good cell‐affinity and effective drug release efficiency, and their woven patches display superior in vivo capability in treating diabetes wounds. Thus, it is believed that the proposed prolamins‐assembled porous hydrogel microfibers will show important values in clinic wound treatments.
Novel prolamins‐assembled porous hydrogel microfibers generated from microfluidic spinning technology for wound healing are presented. The resultant microfibers possess porous structure and could be served as the drug‐loaded carrier. The drug‐loaded microfibers show good cell‐affinity and effective drug release efficiency, which have potential values in wound disease treatment.</description><subject>Acetic acid</subject><subject>Bacitracin</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biopolymers</subject><subject>Deionization</subject><subject>Diabetes</subject><subject>Diabetes Mellitus</subject><subject>Drug delivery systems</subject><subject>drug release</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogels - pharmacology</subject><subject>Microfibers</subject><subject>Microfluidics</subject><subject>Microfluidics - methods</subject><subject>Permeability</subject><subject>Porosity</subject><subject>porous</subject><subject>prolamin</subject><subject>Prolamines</subject><subject>Prolamins - pharmacology</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - pharmacology</subject><subject>Wound Healing</subject><issn>2192-2640</issn><issn>2192-2659</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMottRePcqCFy-t-divHGv9qNCioOIxbHYnNSW7qYmL9OZP8Df6S0xpreDFucww88zLzIvQMcFDgjE9L6qXekgxZZiSDO-hLiWcDmia8P1dHeMO6nu_wCHShKQ5OUQdlvEwznkXiQttl9asanBfH58j76GWBqro3jrb-miyqpydg4lmunRWaQnOR8rZetswra50GT0sddPoZh4p66Jn2zZVNIHChM4ROlCF8dDf5h56ur56HE8G07ub2_FoOihZxvBAJsAxZAQrlXFV5rLApYqJxDyhSsmEVDEmkAItgCVMxiChBKJSKDiXChjrobON7tLZ1xb8m6i1L8GYooHwiKB5njJGcbpGT_-gC9u6JlwnKCd5RtI4sD003FDhTe8dKLF0ui7cShAs1u6Ltfti535YONnKtrKGaof_eB0AvgHetYHVP3JidDmZ_Yp_AzGrkxA</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Wang, Yu</creator><creator>Guo, Jiahui</creator><creator>Luo, Zhiqiang</creator><creator>Shen, Yingbo</creator><creator>Wang, Jinglin</creator><creator>Yu, Yunru</creator><creator>Zhao, Yuanjin</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9242-4000</orcidid></search><sort><creationdate>20240101</creationdate><title>Biopolymer‐Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing</title><author>Wang, Yu ; Guo, Jiahui ; Luo, Zhiqiang ; Shen, Yingbo ; Wang, Jinglin ; Yu, Yunru ; Zhao, Yuanjin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3730-b5e90e710ff79fc8ba0cf41b0952ffb51d401e6e2ae353b4ebece1f6ea99bfe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acetic acid</topic><topic>Bacitracin</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biopolymers</topic><topic>Deionization</topic><topic>Diabetes</topic><topic>Diabetes Mellitus</topic><topic>Drug delivery systems</topic><topic>drug release</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogels - pharmacology</topic><topic>Microfibers</topic><topic>Microfluidics</topic><topic>Microfluidics - methods</topic><topic>Permeability</topic><topic>Porosity</topic><topic>porous</topic><topic>prolamin</topic><topic>Prolamines</topic><topic>Prolamins - pharmacology</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - pharmacology</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Guo, Jiahui</creatorcontrib><creatorcontrib>Luo, Zhiqiang</creatorcontrib><creatorcontrib>Shen, Yingbo</creatorcontrib><creatorcontrib>Wang, Jinglin</creatorcontrib><creatorcontrib>Yu, Yunru</creatorcontrib><creatorcontrib>Zhao, Yuanjin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Immunology Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced healthcare materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yu</au><au>Guo, Jiahui</au><au>Luo, Zhiqiang</au><au>Shen, Yingbo</au><au>Wang, Jinglin</au><au>Yu, Yunru</au><au>Zhao, Yuanjin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biopolymer‐Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing</atitle><jtitle>Advanced healthcare materials</jtitle><addtitle>Adv Healthc Mater</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>13</volume><issue>3</issue><spage>e2302170</spage><epage>n/a</epage><pages>e2302170-n/a</pages><issn>2192-2640</issn><issn>2192-2659</issn><eissn>2192-2659</eissn><abstract>Hydrogels are considered as a promising medical patch for wound healing. Researches in this aspect are focused on improving their compositions and permeability to enhance the effectiveness of wound healing. Here, novel prolamins‐assembled porous hydrogel microfibers with the desired merits for treating diabetes wounds are presented. Such microfibers are continuously generated by one‐step microfluidic spinning technology with acetic acid solution of prolamins as the continuous phase and deionized water as the dispersed phase. By adjusting the prolamin concentration and flow rates of microfluidics, the porous structure and morphology as well as diameters of microfibers can be well tailored. Owing to their porosity, the resultant microfibers can be employed as flexible delivery systems for wound healing actives, such as bacitracin and vascular endothelial growth factor (VEGF). It is demonstrated that the resultant hydrogel microfibers are with good cell‐affinity and effective drug release efficiency, and their woven patches display superior in vivo capability in treating diabetes wounds. Thus, it is believed that the proposed prolamins‐assembled porous hydrogel microfibers will show important values in clinic wound treatments.
Novel prolamins‐assembled porous hydrogel microfibers generated from microfluidic spinning technology for wound healing are presented. The resultant microfibers possess porous structure and could be served as the drug‐loaded carrier. The drug‐loaded microfibers show good cell‐affinity and effective drug release efficiency, which have potential values in wound disease treatment.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37921989</pmid><doi>10.1002/adhm.202302170</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9242-4000</orcidid></addata></record> |
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| subjects | Acetic acid Bacitracin Biocompatible Materials - chemistry Biopolymers Deionization Diabetes Diabetes Mellitus Drug delivery systems drug release Growth factors Humans Hydrogels Hydrogels - chemistry Hydrogels - pharmacology Microfibers Microfluidics Microfluidics - methods Permeability Porosity porous prolamin Prolamines Prolamins - pharmacology Vascular endothelial growth factor Vascular Endothelial Growth Factor A - pharmacology Wound Healing |
| title | Biopolymer‐Assembled Porous Hydrogel Microfibers from Microfluidic Spinning for Wound Healing |
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