Evaluation of Serum Paraoxonase, Myeloperoxidase, and HDL-Cholesterol Levels in Acute Myeloid Leukemia
Inflammation and oxidative stress play a significant role in the pathogenesis of acute myeloid leukemia. While myeloperoxidase carries pro-oxidant effects, HDL-cholesterol and paraoxonase have antioxidant properties. Therefore, we evaluated serum paraoxonase, myeloperoxidase, and HDL-cholesterol lev...
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| Veröffentlicht in: | Inflammation 2023-12, Vol.46 (6), p.2470-2476 |
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| creator | Sincan, Suat Sincan, Gülden Aşkın, Seda Kızıltunç, Ahmet |
| description | Inflammation and oxidative stress play a significant role in the pathogenesis of acute myeloid leukemia. While myeloperoxidase carries pro-oxidant effects, HDL-cholesterol and paraoxonase have antioxidant properties. Therefore, we evaluated serum paraoxonase, myeloperoxidase, and HDL-cholesterol levels in cases with acute myeloid leukemia. Myeloperoxidase, paraoxonase, and HDL-cholesterol levels in 40 acute myeloid leukemia patients and 18 healthy individuals were determined. The relationship between these parameters and other prognostic factors, as well as their association with response to chemotherapy, was investigated. Myeloperoxidase levels were higher, while paraoxonase and HDL-cholesterol levels were lower in acute myeloid leukemia cases compared to the control group (
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| doi_str_mv | 10.1007/s10753-023-01924-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2886326812</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2893280498</sourcerecordid><originalsourceid>FETCH-LOGICAL-c303t-fe9d0555c07cc40bae36e6152fbdb73a4a2bdfd4cde661003e4299dbefe0a3153</originalsourceid><addsrcrecordid>eNp9kMFKxDAQhoMouK6-gKeCFw9WJ0mbtkdZV1eoKKjnkDZT7do2a9Iuu29v3AqCBw_DwOT7h8lHyCmFSwqQXDkKScxDYL5oxqIQ9siExgkPWZyIfTIBLiDkWZYckiPnlgCQZimfkGq-Vs2g-tp0gamCZ7RDGzwpq8zGdMrhRfCwxcas0JpNrXcD1elgcZOHs3fToOv9SxPkuMbGBXUXXJdDj2Oo1n4-fGBbq2NyUKnG4clPn5LX2_nLbBHmj3f3s-s8LDnwPqww0xDHcQlJWUZQKOQCBY1ZVegi4SpSrNCVjkqNQviPc4xYlukCKwTFacyn5Hzcu7Lmc_DXybZ2JTaN6tAMTrI0FZyJlDKPnv1Bl2awnb_OUxlnKUTe0JSwkSqtcc5iJVe2bpXdSgryW70c1UuvXu7US_AhPoach7s3tL-r_0l9ASh5hyc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2893280498</pqid></control><display><type>article</type><title>Evaluation of Serum Paraoxonase, Myeloperoxidase, and HDL-Cholesterol Levels in Acute Myeloid Leukemia</title><source>SpringerLink Journals</source><creator>Sincan, Suat ; Sincan, Gülden ; Aşkın, Seda ; Kızıltunç, Ahmet</creator><creatorcontrib>Sincan, Suat ; Sincan, Gülden ; Aşkın, Seda ; Kızıltunç, Ahmet</creatorcontrib><description>Inflammation and oxidative stress play a significant role in the pathogenesis of acute myeloid leukemia. While myeloperoxidase carries pro-oxidant effects, HDL-cholesterol and paraoxonase have antioxidant properties. Therefore, we evaluated serum paraoxonase, myeloperoxidase, and HDL-cholesterol levels in cases with acute myeloid leukemia. Myeloperoxidase, paraoxonase, and HDL-cholesterol levels in 40 acute myeloid leukemia patients and 18 healthy individuals were determined. The relationship between these parameters and other prognostic factors, as well as their association with response to chemotherapy, was investigated. Myeloperoxidase levels were higher, while paraoxonase and HDL-cholesterol levels were lower in acute myeloid leukemia cases compared to the control group (
p
< 0.001,
p
< 0.001,
p
= 0.006, respectively). The myeloperoxidase level was significantly negatively correlated with paraoxonase and HDL-c levels (
r
= − 0.64,
p
< 0.001;
r
= − 0.27,
p
= 0.02, respectively). Paraoxonase level was positively correlated with HDL level (
r
= 0.34,
p
= 0.04). Lactate dehydrogenase level was negatively correlated with HDL-c and paraoxonase levels and positively correlated with myeloperoxidase level (
r
= − 0.37,
p
= 0.019;
r
= − 0.35,
p
= 0.04;
r
= 0.45,
p
= 0.03, respectively). Following complete remission induction treatment, cases with complete remission had lower myeloperoxidase levels and higher HDL-cholesterol and paraoxonase levels compared to other cases (
p
= 0.03,
p
= 0.01,
p
= 0.04, respectively). Myeloperoxidase levels are higher, while paraoxonase and HDL-cholesterol levels are lower in acute myeloid leukemia cases. The obtained findings emphasize the potential importance of inflammation and oxidative stress in the pathogenesis of acute myeloid leukemia. These parameters can be used as biomarkers for prognosis prediction and prediction of response to chemotherapy.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-023-01924-0</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acute myeloid leukemia ; Biomedical and Life Sciences ; Biomedicine ; Chemotherapy ; Cholesterol ; High density lipoprotein ; Immunology ; Inflammation ; Internal Medicine ; L-Lactate dehydrogenase ; Leukemia ; Medical prognosis ; Oxidants ; Oxidative stress ; Paraoxonase ; Pathogenesis ; Pathology ; Peroxidase ; Pharmacology/Toxicology ; Remission ; Remission (Medicine) ; Rheumatology</subject><ispartof>Inflammation, 2023-12, Vol.46 (6), p.2470-2476</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-fe9d0555c07cc40bae36e6152fbdb73a4a2bdfd4cde661003e4299dbefe0a3153</cites><orcidid>0000-0002-7671-7628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-023-01924-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-023-01924-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Sincan, Suat</creatorcontrib><creatorcontrib>Sincan, Gülden</creatorcontrib><creatorcontrib>Aşkın, Seda</creatorcontrib><creatorcontrib>Kızıltunç, Ahmet</creatorcontrib><title>Evaluation of Serum Paraoxonase, Myeloperoxidase, and HDL-Cholesterol Levels in Acute Myeloid Leukemia</title><title>Inflammation</title><addtitle>Inflammation</addtitle><description>Inflammation and oxidative stress play a significant role in the pathogenesis of acute myeloid leukemia. While myeloperoxidase carries pro-oxidant effects, HDL-cholesterol and paraoxonase have antioxidant properties. Therefore, we evaluated serum paraoxonase, myeloperoxidase, and HDL-cholesterol levels in cases with acute myeloid leukemia. Myeloperoxidase, paraoxonase, and HDL-cholesterol levels in 40 acute myeloid leukemia patients and 18 healthy individuals were determined. The relationship between these parameters and other prognostic factors, as well as their association with response to chemotherapy, was investigated. Myeloperoxidase levels were higher, while paraoxonase and HDL-cholesterol levels were lower in acute myeloid leukemia cases compared to the control group (
p
< 0.001,
p
< 0.001,
p
= 0.006, respectively). The myeloperoxidase level was significantly negatively correlated with paraoxonase and HDL-c levels (
r
= − 0.64,
p
< 0.001;
r
= − 0.27,
p
= 0.02, respectively). Paraoxonase level was positively correlated with HDL level (
r
= 0.34,
p
= 0.04). Lactate dehydrogenase level was negatively correlated with HDL-c and paraoxonase levels and positively correlated with myeloperoxidase level (
r
= − 0.37,
p
= 0.019;
r
= − 0.35,
p
= 0.04;
r
= 0.45,
p
= 0.03, respectively). Following complete remission induction treatment, cases with complete remission had lower myeloperoxidase levels and higher HDL-cholesterol and paraoxonase levels compared to other cases (
p
= 0.03,
p
= 0.01,
p
= 0.04, respectively). Myeloperoxidase levels are higher, while paraoxonase and HDL-cholesterol levels are lower in acute myeloid leukemia cases. The obtained findings emphasize the potential importance of inflammation and oxidative stress in the pathogenesis of acute myeloid leukemia. These parameters can be used as biomarkers for prognosis prediction and prediction of response to chemotherapy.</description><subject>Acute myeloid leukemia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chemotherapy</subject><subject>Cholesterol</subject><subject>High density lipoprotein</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>L-Lactate dehydrogenase</subject><subject>Leukemia</subject><subject>Medical prognosis</subject><subject>Oxidants</subject><subject>Oxidative stress</subject><subject>Paraoxonase</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Peroxidase</subject><subject>Pharmacology/Toxicology</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Rheumatology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kMFKxDAQhoMouK6-gKeCFw9WJ0mbtkdZV1eoKKjnkDZT7do2a9Iuu29v3AqCBw_DwOT7h8lHyCmFSwqQXDkKScxDYL5oxqIQ9siExgkPWZyIfTIBLiDkWZYckiPnlgCQZimfkGq-Vs2g-tp0gamCZ7RDGzwpq8zGdMrhRfCwxcas0JpNrXcD1elgcZOHs3fToOv9SxPkuMbGBXUXXJdDj2Oo1n4-fGBbq2NyUKnG4clPn5LX2_nLbBHmj3f3s-s8LDnwPqww0xDHcQlJWUZQKOQCBY1ZVegi4SpSrNCVjkqNQviPc4xYlukCKwTFacyn5Hzcu7Lmc_DXybZ2JTaN6tAMTrI0FZyJlDKPnv1Bl2awnb_OUxlnKUTe0JSwkSqtcc5iJVe2bpXdSgryW70c1UuvXu7US_AhPoach7s3tL-r_0l9ASh5hyc</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Sincan, Suat</creator><creator>Sincan, Gülden</creator><creator>Aşkın, Seda</creator><creator>Kızıltunç, Ahmet</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7671-7628</orcidid></search><sort><creationdate>20231201</creationdate><title>Evaluation of Serum Paraoxonase, Myeloperoxidase, and HDL-Cholesterol Levels in Acute Myeloid Leukemia</title><author>Sincan, Suat ; Sincan, Gülden ; Aşkın, Seda ; Kızıltunç, Ahmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-fe9d0555c07cc40bae36e6152fbdb73a4a2bdfd4cde661003e4299dbefe0a3153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute myeloid leukemia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chemotherapy</topic><topic>Cholesterol</topic><topic>High density lipoprotein</topic><topic>Immunology</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>L-Lactate dehydrogenase</topic><topic>Leukemia</topic><topic>Medical prognosis</topic><topic>Oxidants</topic><topic>Oxidative stress</topic><topic>Paraoxonase</topic><topic>Pathogenesis</topic><topic>Pathology</topic><topic>Peroxidase</topic><topic>Pharmacology/Toxicology</topic><topic>Remission</topic><topic>Remission (Medicine)</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sincan, Suat</creatorcontrib><creatorcontrib>Sincan, Gülden</creatorcontrib><creatorcontrib>Aşkın, Seda</creatorcontrib><creatorcontrib>Kızıltunç, Ahmet</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sincan, Suat</au><au>Sincan, Gülden</au><au>Aşkın, Seda</au><au>Kızıltunç, Ahmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Serum Paraoxonase, Myeloperoxidase, and HDL-Cholesterol Levels in Acute Myeloid Leukemia</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>46</volume><issue>6</issue><spage>2470</spage><epage>2476</epage><pages>2470-2476</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Inflammation and oxidative stress play a significant role in the pathogenesis of acute myeloid leukemia. While myeloperoxidase carries pro-oxidant effects, HDL-cholesterol and paraoxonase have antioxidant properties. Therefore, we evaluated serum paraoxonase, myeloperoxidase, and HDL-cholesterol levels in cases with acute myeloid leukemia. Myeloperoxidase, paraoxonase, and HDL-cholesterol levels in 40 acute myeloid leukemia patients and 18 healthy individuals were determined. The relationship between these parameters and other prognostic factors, as well as their association with response to chemotherapy, was investigated. Myeloperoxidase levels were higher, while paraoxonase and HDL-cholesterol levels were lower in acute myeloid leukemia cases compared to the control group (
p
< 0.001,
p
< 0.001,
p
= 0.006, respectively). The myeloperoxidase level was significantly negatively correlated with paraoxonase and HDL-c levels (
r
= − 0.64,
p
< 0.001;
r
= − 0.27,
p
= 0.02, respectively). Paraoxonase level was positively correlated with HDL level (
r
= 0.34,
p
= 0.04). Lactate dehydrogenase level was negatively correlated with HDL-c and paraoxonase levels and positively correlated with myeloperoxidase level (
r
= − 0.37,
p
= 0.019;
r
= − 0.35,
p
= 0.04;
r
= 0.45,
p
= 0.03, respectively). Following complete remission induction treatment, cases with complete remission had lower myeloperoxidase levels and higher HDL-cholesterol and paraoxonase levels compared to other cases (
p
= 0.03,
p
= 0.01,
p
= 0.04, respectively). Myeloperoxidase levels are higher, while paraoxonase and HDL-cholesterol levels are lower in acute myeloid leukemia cases. The obtained findings emphasize the potential importance of inflammation and oxidative stress in the pathogenesis of acute myeloid leukemia. These parameters can be used as biomarkers for prognosis prediction and prediction of response to chemotherapy.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10753-023-01924-0</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7671-7628</orcidid></addata></record> |
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| ispartof | Inflammation, 2023-12, Vol.46 (6), p.2470-2476 |
| issn | 0360-3997 1573-2576 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | Acute myeloid leukemia Biomedical and Life Sciences Biomedicine Chemotherapy Cholesterol High density lipoprotein Immunology Inflammation Internal Medicine L-Lactate dehydrogenase Leukemia Medical prognosis Oxidants Oxidative stress Paraoxonase Pathogenesis Pathology Peroxidase Pharmacology/Toxicology Remission Remission (Medicine) Rheumatology |
| title | Evaluation of Serum Paraoxonase, Myeloperoxidase, and HDL-Cholesterol Levels in Acute Myeloid Leukemia |
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