Neferine exerts anti‑inflammatory activity in BV‑2 microglial cells and protects mice with MPTP‑induced Parkinson's disease by inhibiting NF‑κB activation

Abnormal activation of microglia and the production of proinflammatory cytokines can lead to chronic neuroinflammation, which is an important pathological characteristic of Parkinson's disease (PD). Neferine is a chemical compound extracted from lotus seed which has previously been reported to...

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Veröffentlicht in:	Molecular medicine reports 2023-12, Vol.28 (6), Article 235
Hauptverfasser:	Li, Ting, Zhai, Yun Xin, Zheng, Tianyi, Xu, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Brain damage Cell death Cytokines Cytotoxicity Disease Encephalopathy Gene amplification Hypoxia Inflammation Interleukin 6 Invoices Ischemia Kinases Laboratories Lipopolysaccharides Microglia Movement disorders MPTP Nervous system Neurodegeneration Neurodegenerative diseases NF-κB protein Nitric-oxide synthase Nuclear transport Parkinson's disease Phosphorylation Proteins Substantia nigra Tumor necrosis factor-TNF
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