Getting to the heart of thick-filament structure

Thick filaments contain the protein myosin that generates the force of every heartbeat. Two studies report how these myosin molecules pack together in thick filaments with other proteins to form a surprisingly complex structure. Cryo-electron microscopy reveals the structure of muscle thick filament...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 2023-11, Vol.623 (7988), p.703-704
1. Verfasser: Knight, Peter J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 704
container_issue 7988
container_start_page 703
container_title Nature (London)
container_volume 623
creator Knight, Peter J.
description Thick filaments contain the protein myosin that generates the force of every heartbeat. Two studies report how these myosin molecules pack together in thick filaments with other proteins to form a surprisingly complex structure. Cryo-electron microscopy reveals the structure of muscle thick filaments.
doi_str_mv 10.1038/d41586-023-03307-9
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2885541180</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2885541180</sourcerecordid><originalsourceid>FETCH-LOGICAL-c303t-df89dcbc3b9fc81dc593516b549eba952942ef4f4e07101fe9190e93ac2a35a03</originalsourceid><addsrcrecordid>eNp9kEFLwzAYhoMoOKd_wFPBi5folyZpk6MMncLAi55Dmn7ZOrt2JunBf2-3CoIHTx8vPO_Lx0PINYM7Blzd14JJVVDIOQXOoaT6hMyYKAsqClWekhlArigoXpyTixi3ACBZKWYElphS062z1Gdpg9kGbUhZ78fQuA_qm9busEtZTGFwaQh4Sc68bSNe_dw5eX96fFs809Xr8mXxsKKOA0-09krXrnK80t4pVjupuWRFJYXGymqZa5GjF14glAyYR800oObW5ZZLC3xObqfdfeg_B4zJ7JrosG1th_0QTa6UlIIxdUBv_qDbfgjd-N1IaSEKrhUbqXyiXOhjDOjNPjQ7G74MA3OQaCaJZpRojhKNHkt8KsUR7tYYfqf_aX0D6flzDQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2894463981</pqid></control><display><type>article</type><title>Getting to the heart of thick-filament structure</title><source>Nature Journals Online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Knight, Peter J.</creator><creatorcontrib>Knight, Peter J.</creatorcontrib><description>Thick filaments contain the protein myosin that generates the force of every heartbeat. Two studies report how these myosin molecules pack together in thick filaments with other proteins to form a surprisingly complex structure. Cryo-electron microscopy reveals the structure of muscle thick filaments.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/d41586-023-03307-9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/535 ; Arrays ; Cardiovascular diseases ; Connectin ; Electron microscopy ; Heart diseases ; Heart function ; Humanities and Social Sciences ; Invertebrates ; multidisciplinary ; Musculoskeletal system ; Myosin ; News And Views ; Proteins ; Science ; Vertebrates</subject><ispartof>Nature (London), 2023-11, Vol.623 (7988), p.703-704</ispartof><rights>Springer Nature Limited 2023</rights><rights>Copyright Nature Publishing Group Nov 23, 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-df89dcbc3b9fc81dc593516b549eba952942ef4f4e07101fe9190e93ac2a35a03</cites><orcidid>0000-0002-8850-9500</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/d41586-023-03307-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/d41586-023-03307-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Knight, Peter J.</creatorcontrib><title>Getting to the heart of thick-filament structure</title><title>Nature (London)</title><addtitle>Nature</addtitle><description>Thick filaments contain the protein myosin that generates the force of every heartbeat. Two studies report how these myosin molecules pack together in thick filaments with other proteins to form a surprisingly complex structure. Cryo-electron microscopy reveals the structure of muscle thick filaments.</description><subject>631/535</subject><subject>Arrays</subject><subject>Cardiovascular diseases</subject><subject>Connectin</subject><subject>Electron microscopy</subject><subject>Heart diseases</subject><subject>Heart function</subject><subject>Humanities and Social Sciences</subject><subject>Invertebrates</subject><subject>multidisciplinary</subject><subject>Musculoskeletal system</subject><subject>Myosin</subject><subject>News And Views</subject><subject>Proteins</subject><subject>Science</subject><subject>Vertebrates</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kEFLwzAYhoMoOKd_wFPBi5folyZpk6MMncLAi55Dmn7ZOrt2JunBf2-3CoIHTx8vPO_Lx0PINYM7Blzd14JJVVDIOQXOoaT6hMyYKAsqClWekhlArigoXpyTixi3ACBZKWYElphS062z1Gdpg9kGbUhZ78fQuA_qm9busEtZTGFwaQh4Sc68bSNe_dw5eX96fFs809Xr8mXxsKKOA0-09krXrnK80t4pVjupuWRFJYXGymqZa5GjF14glAyYR800oObW5ZZLC3xObqfdfeg_B4zJ7JrosG1th_0QTa6UlIIxdUBv_qDbfgjd-N1IaSEKrhUbqXyiXOhjDOjNPjQ7G74MA3OQaCaJZpRojhKNHkt8KsUR7tYYfqf_aX0D6flzDQ</recordid><startdate>20231123</startdate><enddate>20231123</enddate><creator>Knight, Peter J.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8850-9500</orcidid></search><sort><creationdate>20231123</creationdate><title>Getting to the heart of thick-filament structure</title><author>Knight, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-df89dcbc3b9fc81dc593516b549eba952942ef4f4e07101fe9190e93ac2a35a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>631/535</topic><topic>Arrays</topic><topic>Cardiovascular diseases</topic><topic>Connectin</topic><topic>Electron microscopy</topic><topic>Heart diseases</topic><topic>Heart function</topic><topic>Humanities and Social Sciences</topic><topic>Invertebrates</topic><topic>multidisciplinary</topic><topic>Musculoskeletal system</topic><topic>Myosin</topic><topic>News And Views</topic><topic>Proteins</topic><topic>Science</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knight, Peter J.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric &amp; Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric &amp; Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knight, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Getting to the heart of thick-filament structure</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><date>2023-11-23</date><risdate>2023</risdate><volume>623</volume><issue>7988</issue><spage>703</spage><epage>704</epage><pages>703-704</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Thick filaments contain the protein myosin that generates the force of every heartbeat. Two studies report how these myosin molecules pack together in thick filaments with other proteins to form a surprisingly complex structure. Cryo-electron microscopy reveals the structure of muscle thick filaments.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/d41586-023-03307-9</doi><tpages>2</tpages><orcidid>https://orcid.org/0000-0002-8850-9500</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0028-0836
ispartof Nature (London), 2023-11, Vol.623 (7988), p.703-704
issn 0028-0836
1476-4687
language eng
recordid cdi_proquest_miscellaneous_2885541180
source Nature Journals Online; SpringerLink Journals - AutoHoldings
subjects 631/535
Arrays
Cardiovascular diseases
Connectin
Electron microscopy
Heart diseases
Heart function
Humanities and Social Sciences
Invertebrates
multidisciplinary
Musculoskeletal system
Myosin
News And Views
Proteins
Science
Vertebrates
title Getting to the heart of thick-filament structure
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T18%3A35%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Getting%20to%20the%20heart%20of%20thick-filament%20structure&rft.jtitle=Nature%20(London)&rft.au=Knight,%20Peter%20J.&rft.date=2023-11-23&rft.volume=623&rft.issue=7988&rft.spage=703&rft.epage=704&rft.pages=703-704&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/d41586-023-03307-9&rft_dat=%3Cproquest_cross%3E2885541180%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2894463981&rft_id=info:pmid/&rfr_iscdi=true