Discovery of novel tetrahydrobenzothiophene derivatives as MSBA inhibitors for antimicrobial agents

[Display omitted] •Novel tetrahydrobenzothiophene antibacterial compounds were designed and synthesized.•Compound 6p holds promise as a potential therapeutic agent for combating bacterial infections.•The structure–activity relationship of tetrahydrobenzothiophene antibacterial molecules was studied....

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Veröffentlicht in:	Bioorganic chemistry 2024-01, Vol.142, p.106932-106932, Article 106932
Hauptverfasser:	Lai, Lin, Sun, Wanlin, Lu, Zhaoyang, Su, Xiaoyan, Hao, Jielei, Liu, Yuheng, Wu, Wen, Guan, Shan, Pei, Shuchen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Infective Agents - pharmacology Antibacterial Bacteria Drug desigen Humans Mice Microbial Sensitivity Tests Synthesis Tetrahydrobenzothiophene
Online-Zugang:	Volltext
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