Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors
Repeated closed head injury (rCHI) is one of the most common brain injuries. Although extensive studies have focused on how to treat rCHI‐induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI‐induced anxiety has received little research attention. The...
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Veröffentlicht in: | Journal of biophotonics 2024-02, Vol.17 (2), p.e202300343-n/a |
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description | Repeated closed head injury (rCHI) is one of the most common brain injuries. Although extensive studies have focused on how to treat rCHI‐induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI‐induced anxiety has received little research attention. The current study was designed to assess the effects of photobiomodulation (PBM) therapy in preventing anxiety following rCHI. The rCHI disease model was constructed by administering three repeated closed‐head injuries within an interval 5 days. 2‐min daily PBM therapy using an 808 nm continuous wave laser at 350 mW/cm2 on the scalp was implemented for 20 days. We found that PBM significantly ameliorated rCHII‐induced anxiety‐like behaviors, neuronal apoptosis, neuronal injury, promotes astrocyte/microglial polarization to anti‐inflammatory phenotype, preserves mitochondrial fusion‐related protein MFN2, attenuates the elevated mitochondrial fission‐related protein DRP1, and mitigates neuronal senescence. We concluded that PBM therapy possesses great potential in preventing anxiety following rCHI.
PBM therapy promotes glial cell polarization toward the neuroprotective A2/M2 phenotype, preserves mitochondrial dynamics, alleviates secondary injury and neuronal senescence, and produces anxiolytic effects. |
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PBM therapy promotes glial cell polarization toward the neuroprotective A2/M2 phenotype, preserves mitochondrial dynamics, alleviates secondary injury and neuronal senescence, and produces anxiolytic effects.</description><identifier>ISSN: 1864-063X</identifier><identifier>ISSN: 1864-0648</identifier><identifier>EISSN: 1864-0648</identifier><identifier>DOI: 10.1002/jbio.202300343</identifier><identifier>PMID: 37909411</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH & Co. KGaA</publisher><subject>Anxiety ; Anxiety - etiology ; Anxiety - prevention & control ; Apoptosis ; Brain ; Brain injury ; Continuous wave lasers ; Fusion protein ; glial polarization ; Head injuries ; Head Injuries, Closed ; Humans ; Inflammation ; Injuries ; Injury prevention ; Low-Level Light Therapy ; neuronal senescence ; Neurons ; Phenotypes ; photobiomodulation ; Proteins ; repeated closed head injury ; Senescence ; Therapy</subject><ispartof>Journal of biophotonics, 2024-02, Vol.17 (2), p.e202300343-n/a</ispartof><rights>2023 Wiley‐VCH GmbH.</rights><rights>2023 Wiley-VCH GmbH.</rights><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3733-ff736630b5395139e661681351ebcea2d0c2799a4e8a2c0945f0c6c540052a363</citedby><cites>FETCH-LOGICAL-c3733-ff736630b5395139e661681351ebcea2d0c2799a4e8a2c0945f0c6c540052a363</cites><orcidid>0000-0001-7916-7054</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbio.202300343$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbio.202300343$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27925,27926,45575,45576</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37909411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zhe</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Wu, Chongyun</creatorcontrib><creatorcontrib>Su, Yanlin</creatorcontrib><creatorcontrib>Feng, Shu</creatorcontrib><creatorcontrib>Deng, Qianting</creatorcontrib><creatorcontrib>Zou, Peibin</creatorcontrib><creatorcontrib>Liu, Timon Cheng‐Yi</creatorcontrib><creatorcontrib>Duan, Rui</creatorcontrib><creatorcontrib>Yang, Luodan</creatorcontrib><title>Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors</title><title>Journal of biophotonics</title><addtitle>J Biophotonics</addtitle><description>Repeated closed head injury (rCHI) is one of the most common brain injuries. Although extensive studies have focused on how to treat rCHI‐induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI‐induced anxiety has received little research attention. The current study was designed to assess the effects of photobiomodulation (PBM) therapy in preventing anxiety following rCHI. The rCHI disease model was constructed by administering three repeated closed‐head injuries within an interval 5 days. 2‐min daily PBM therapy using an 808 nm continuous wave laser at 350 mW/cm2 on the scalp was implemented for 20 days. We found that PBM significantly ameliorated rCHII‐induced anxiety‐like behaviors, neuronal apoptosis, neuronal injury, promotes astrocyte/microglial polarization to anti‐inflammatory phenotype, preserves mitochondrial fusion‐related protein MFN2, attenuates the elevated mitochondrial fission‐related protein DRP1, and mitigates neuronal senescence. We concluded that PBM therapy possesses great potential in preventing anxiety following rCHI.
PBM therapy promotes glial cell polarization toward the neuroprotective A2/M2 phenotype, preserves mitochondrial dynamics, alleviates secondary injury and neuronal senescence, and produces anxiolytic effects.</description><subject>Anxiety</subject><subject>Anxiety - etiology</subject><subject>Anxiety - prevention & control</subject><subject>Apoptosis</subject><subject>Brain</subject><subject>Brain injury</subject><subject>Continuous wave lasers</subject><subject>Fusion protein</subject><subject>glial polarization</subject><subject>Head injuries</subject><subject>Head Injuries, Closed</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Injuries</subject><subject>Injury prevention</subject><subject>Low-Level Light Therapy</subject><subject>neuronal senescence</subject><subject>Neurons</subject><subject>Phenotypes</subject><subject>photobiomodulation</subject><subject>Proteins</subject><subject>repeated closed head injury</subject><subject>Senescence</subject><subject>Therapy</subject><issn>1864-063X</issn><issn>1864-0648</issn><issn>1864-0648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFuEzEQhq2KiraBa49oJS69JIw9u876CFUpRZXKoZW4WV7vrOLgrFN7tyU3HoFn5ElwlJJKvXCa0eibb-yfsVMOMw4gPiwbF2YCBAJgiQfsmNeynIIs61f7Hr8fsZOUlgASsMLX7AjnClTJ-TFrvy3CELJkFdrRm8GFvhgWFM16Uxjv6cGZgVIRaU25aQvrQ8plQaYtXL8c4-bPr9-ub0ebp6b_6WjYTrz7QUVDC_PgQkxv2GFnfKK3T3XC7j5f3J5_mV7fXF6df7yeWpwjTrtujlIiNBWqiqMiKbmsOVacGktGtGDFXClTUm2EzR-oOrDSViVAJQxKnLCznXcdw_1IadArlyx5b3oKY9KiriuR2Xxswt6_QJdhjH1-nRYKc0yqFJCp2Y6yMaQUqdPr6FYmbjQHvc1fb_PX-_zzwrsn7disqN3j_wLPgNoBj87T5j86_fXT1c2z_C_3EJQa</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Chen, Zhe</creator><creator>Li, Meng</creator><creator>Wu, Chongyun</creator><creator>Su, Yanlin</creator><creator>Feng, Shu</creator><creator>Deng, Qianting</creator><creator>Zou, Peibin</creator><creator>Liu, Timon Cheng‐Yi</creator><creator>Duan, Rui</creator><creator>Yang, Luodan</creator><general>WILEY‐VCH Verlag GmbH & Co. KGaA</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>K9.</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7916-7054</orcidid></search><sort><creationdate>202402</creationdate><title>Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors</title><author>Chen, Zhe ; Li, Meng ; Wu, Chongyun ; Su, Yanlin ; Feng, Shu ; Deng, Qianting ; Zou, Peibin ; Liu, Timon Cheng‐Yi ; Duan, Rui ; Yang, Luodan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3733-ff736630b5395139e661681351ebcea2d0c2799a4e8a2c0945f0c6c540052a363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anxiety</topic><topic>Anxiety - etiology</topic><topic>Anxiety - prevention & control</topic><topic>Apoptosis</topic><topic>Brain</topic><topic>Brain injury</topic><topic>Continuous wave lasers</topic><topic>Fusion protein</topic><topic>glial polarization</topic><topic>Head injuries</topic><topic>Head Injuries, Closed</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Injuries</topic><topic>Injury prevention</topic><topic>Low-Level Light Therapy</topic><topic>neuronal senescence</topic><topic>Neurons</topic><topic>Phenotypes</topic><topic>photobiomodulation</topic><topic>Proteins</topic><topic>repeated closed head injury</topic><topic>Senescence</topic><topic>Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zhe</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Wu, Chongyun</creatorcontrib><creatorcontrib>Su, Yanlin</creatorcontrib><creatorcontrib>Feng, Shu</creatorcontrib><creatorcontrib>Deng, Qianting</creatorcontrib><creatorcontrib>Zou, Peibin</creatorcontrib><creatorcontrib>Liu, Timon Cheng‐Yi</creatorcontrib><creatorcontrib>Duan, Rui</creatorcontrib><creatorcontrib>Yang, Luodan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biophotonics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zhe</au><au>Li, Meng</au><au>Wu, Chongyun</au><au>Su, Yanlin</au><au>Feng, Shu</au><au>Deng, Qianting</au><au>Zou, Peibin</au><au>Liu, Timon Cheng‐Yi</au><au>Duan, Rui</au><au>Yang, Luodan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors</atitle><jtitle>Journal of biophotonics</jtitle><addtitle>J Biophotonics</addtitle><date>2024-02</date><risdate>2024</risdate><volume>17</volume><issue>2</issue><spage>e202300343</spage><epage>n/a</epage><pages>e202300343-n/a</pages><issn>1864-063X</issn><issn>1864-0648</issn><eissn>1864-0648</eissn><abstract>Repeated closed head injury (rCHI) is one of the most common brain injuries. Although extensive studies have focused on how to treat rCHI‐induced brain injury and reduce the possibility of developing memory deficits, the prevention of rCHI‐induced anxiety has received little research attention. The current study was designed to assess the effects of photobiomodulation (PBM) therapy in preventing anxiety following rCHI. The rCHI disease model was constructed by administering three repeated closed‐head injuries within an interval 5 days. 2‐min daily PBM therapy using an 808 nm continuous wave laser at 350 mW/cm2 on the scalp was implemented for 20 days. We found that PBM significantly ameliorated rCHII‐induced anxiety‐like behaviors, neuronal apoptosis, neuronal injury, promotes astrocyte/microglial polarization to anti‐inflammatory phenotype, preserves mitochondrial fusion‐related protein MFN2, attenuates the elevated mitochondrial fission‐related protein DRP1, and mitigates neuronal senescence. We concluded that PBM therapy possesses great potential in preventing anxiety following rCHI.
PBM therapy promotes glial cell polarization toward the neuroprotective A2/M2 phenotype, preserves mitochondrial dynamics, alleviates secondary injury and neuronal senescence, and produces anxiolytic effects.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH & Co. KGaA</pub><pmid>37909411</pmid><doi>10.1002/jbio.202300343</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-7916-7054</orcidid></addata></record> |
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subjects | Anxiety Anxiety - etiology Anxiety - prevention & control Apoptosis Brain Brain injury Continuous wave lasers Fusion protein glial polarization Head injuries Head Injuries, Closed Humans Inflammation Injuries Injury prevention Low-Level Light Therapy neuronal senescence Neurons Phenotypes photobiomodulation Proteins repeated closed head injury Senescence Therapy |
title | Photobiomodulation therapy alleviates repeated closed head injury‐induced anxiety‐like behaviors |
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