Wnt5a/Ror2 promotes Nrf2‐mediated tissue protective function of astrocytes after brain injury

Astrocytes, a type of glial cells, play critical roles in promoting the protection and repair of damaged tissues after brain injury. Inflammatory cytokines and growth factors can affect gene expression in astrocytes in injured brains, but signaling pathways and transcriptional mechanisms that regula...

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Veröffentlicht in:	Glia 2024-02, Vol.72 (2), p.411-432
Hauptverfasser:	Endo, Mitsuharu, Tanaka, Yuki, Fukuoka, Mayo, Suzuki, Hayata, Minami, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Astrocytes Astrocytes - metabolism bFGF Blood-brain barrier Brain damage Brain Injuries - genetics Brain Injuries - metabolism Brain injury Collagenase Cytokines Cytokines - metabolism Fibroblast growth factor 2 Gene expression Glial cells Growth factors Head injuries Heme oxygenase (decyclizing) Hemin Hemoglobin Hemorrhage Inflammation Mice Molecular modelling NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 oxidative stress reactive astrocytes Receptor Tyrosine Kinase-like Orphan Receptors - metabolism Ror2 Signal Transduction Tissues Traumatic brain injury Wnt protein Wnt-5a Protein - metabolism Wnt5a
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