Prevalence and Impact of Frailty in Pancreatic Cancer: A Systematic Review and Meta-Analysis Based on 35,191 Patients
Background Frailty has been associated with increased mortality among patients with pancreatic cancer. Nevertheless, several lines of evidence regarding the prevalence of frailty in patients with pancreatic cancer and mortality in patients with pancreatic cancer and frailty have not been thoroughly...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology 2024, Vol.31 (1), p.535-544 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 544 |
|---|---|
| container_issue | 1 |
| container_start_page | 535 |
| container_title | Annals of surgical oncology |
| container_volume | 31 |
| creator | Zhang, Fei Yan, Ying Ge, Chunlin |
| description | Background
Frailty has been associated with increased mortality among patients with pancreatic cancer. Nevertheless, several lines of evidence regarding the prevalence of frailty in patients with pancreatic cancer and mortality in patients with pancreatic cancer and frailty have not been thoroughly investigated and require clarification.
Methods
A systematic review and meta-analysis of studies indexed in PubMed, Scopus, Web of Science, and Embase through March 2023 were conducted, and the pooled prevalence and relative risk (RR) estimate were calculated.
Results
A total of 18 studies containing 35,191 patients with pancreatic cancer were included. The prevalence of frailty in pancreatic cancer was 45% (95% CI = 29–62;
I
2
= 99.9%;
p
= 0.000). In patients with pancreatic cancer, frailty was associated with increased relative risk for mortality (RR = 1.70; 95% CI = 1.30–2.22;
I
2
= 84.8%,
p
= 0.000).
Conclusions
Frailty prevalence in pancreatic cancer is common and exerts a significant negative impact on the survival of patients with pancreatic cancer. Our findings are characterized by significant heterogeneity, and caution is warranted in their interpretation. However, these findings highlight the importance of evaluating frailty, which may provide prognostic data and inform decision-making priorities. |
| doi_str_mv | 10.1245/s10434-023-14426-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2884182086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2884182086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-90db9c3e76bc52394479a1286ef43ab1848a15c39650385252b17cca2da7a0553</originalsourceid><addsrcrecordid>eNp9kUtv1DAURiNERR_wB1ggS2xYNMXP2GY3jChUKqLisbZunDsoVeIMtlOUf1_PTAGJRVe-uj7fsayvql4yesG4VG8To1LImnJRMyl5Uy9PqhOmyko2hj0tM21MbXmjjqvTlG4pZVpQ9aw6FtpYK5k6qeabiHcwYPBIIHTkatyCz2TakMsI_ZAX0gdyA8FHhNx7si4jxndkRb4tKeO4X37Fux5_7_OfMUO9CjAsqU_kPSTsyBSIUOfMsiLKPYacnldHGxgSvng4z6oflx--rz_V118-Xq1X17UXWuXa0q61XqBuWq-4sFJqC4ybBjdSQMuMNMCUF7ZRVBjFFW-Z9h54BxqoUuKsenPwbuP0a8aU3dgnj8MAAac5OW6MZIZT0xT09X_o7TTH8pEdZbVi2vCdkB8oH6eUIm7cNvYjxMUx6naluEMprpTi9qW4pYRePajndsTub-RPCwUQByCVq_AT47-3H9HeA-nulVg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2897517825</pqid></control><display><type>article</type><title>Prevalence and Impact of Frailty in Pancreatic Cancer: A Systematic Review and Meta-Analysis Based on 35,191 Patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zhang, Fei ; Yan, Ying ; Ge, Chunlin</creator><creatorcontrib>Zhang, Fei ; Yan, Ying ; Ge, Chunlin</creatorcontrib><description>Background
Frailty has been associated with increased mortality among patients with pancreatic cancer. Nevertheless, several lines of evidence regarding the prevalence of frailty in patients with pancreatic cancer and mortality in patients with pancreatic cancer and frailty have not been thoroughly investigated and require clarification.
Methods
A systematic review and meta-analysis of studies indexed in PubMed, Scopus, Web of Science, and Embase through March 2023 were conducted, and the pooled prevalence and relative risk (RR) estimate were calculated.
Results
A total of 18 studies containing 35,191 patients with pancreatic cancer were included. The prevalence of frailty in pancreatic cancer was 45% (95% CI = 29–62;
I
2
= 99.9%;
p
= 0.000). In patients with pancreatic cancer, frailty was associated with increased relative risk for mortality (RR = 1.70; 95% CI = 1.30–2.22;
I
2
= 84.8%,
p
= 0.000).
Conclusions
Frailty prevalence in pancreatic cancer is common and exerts a significant negative impact on the survival of patients with pancreatic cancer. Our findings are characterized by significant heterogeneity, and caution is warranted in their interpretation. However, these findings highlight the importance of evaluating frailty, which may provide prognostic data and inform decision-making priorities.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-023-14426-y</identifier><identifier>PMID: 37899415</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Decision making ; Frail Elderly ; Frailty ; Frailty - epidemiology ; Humans ; Medicine ; Medicine & Public Health ; Meta-analysis ; Mortality ; Oncology ; Pancreatic cancer ; Pancreatic Neoplasms - epidemiology ; Pancreatic Tumors ; Prevalence ; Prognosis ; Surgery ; Surgical Oncology ; Systematic review</subject><ispartof>Annals of surgical oncology, 2024, Vol.31 (1), p.535-544</ispartof><rights>Society of Surgical Oncology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Society of Surgical Oncology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-90db9c3e76bc52394479a1286ef43ab1848a15c39650385252b17cca2da7a0553</citedby><cites>FETCH-LOGICAL-c375t-90db9c3e76bc52394479a1286ef43ab1848a15c39650385252b17cca2da7a0553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-023-14426-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-023-14426-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37899415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Fei</creatorcontrib><creatorcontrib>Yan, Ying</creatorcontrib><creatorcontrib>Ge, Chunlin</creatorcontrib><title>Prevalence and Impact of Frailty in Pancreatic Cancer: A Systematic Review and Meta-Analysis Based on 35,191 Patients</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Frailty has been associated with increased mortality among patients with pancreatic cancer. Nevertheless, several lines of evidence regarding the prevalence of frailty in patients with pancreatic cancer and mortality in patients with pancreatic cancer and frailty have not been thoroughly investigated and require clarification.
Methods
A systematic review and meta-analysis of studies indexed in PubMed, Scopus, Web of Science, and Embase through March 2023 were conducted, and the pooled prevalence and relative risk (RR) estimate were calculated.
Results
A total of 18 studies containing 35,191 patients with pancreatic cancer were included. The prevalence of frailty in pancreatic cancer was 45% (95% CI = 29–62;
I
2
= 99.9%;
p
= 0.000). In patients with pancreatic cancer, frailty was associated with increased relative risk for mortality (RR = 1.70; 95% CI = 1.30–2.22;
I
2
= 84.8%,
p
= 0.000).
Conclusions
Frailty prevalence in pancreatic cancer is common and exerts a significant negative impact on the survival of patients with pancreatic cancer. Our findings are characterized by significant heterogeneity, and caution is warranted in their interpretation. However, these findings highlight the importance of evaluating frailty, which may provide prognostic data and inform decision-making priorities.</description><subject>Aged</subject><subject>Decision making</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Frailty - epidemiology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Mortality</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Tumors</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Systematic review</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtv1DAURiNERR_wB1ggS2xYNMXP2GY3jChUKqLisbZunDsoVeIMtlOUf1_PTAGJRVe-uj7fsayvql4yesG4VG8To1LImnJRMyl5Uy9PqhOmyko2hj0tM21MbXmjjqvTlG4pZVpQ9aw6FtpYK5k6qeabiHcwYPBIIHTkatyCz2TakMsI_ZAX0gdyA8FHhNx7si4jxndkRb4tKeO4X37Fux5_7_OfMUO9CjAsqU_kPSTsyBSIUOfMsiLKPYacnldHGxgSvng4z6oflx--rz_V118-Xq1X17UXWuXa0q61XqBuWq-4sFJqC4ybBjdSQMuMNMCUF7ZRVBjFFW-Z9h54BxqoUuKsenPwbuP0a8aU3dgnj8MAAac5OW6MZIZT0xT09X_o7TTH8pEdZbVi2vCdkB8oH6eUIm7cNvYjxMUx6naluEMprpTi9qW4pYRePajndsTub-RPCwUQByCVq_AT47-3H9HeA-nulVg</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Zhang, Fei</creator><creator>Yan, Ying</creator><creator>Ge, Chunlin</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>2024</creationdate><title>Prevalence and Impact of Frailty in Pancreatic Cancer: A Systematic Review and Meta-Analysis Based on 35,191 Patients</title><author>Zhang, Fei ; Yan, Ying ; Ge, Chunlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-90db9c3e76bc52394479a1286ef43ab1848a15c39650385252b17cca2da7a0553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Decision making</topic><topic>Frail Elderly</topic><topic>Frailty</topic><topic>Frailty - epidemiology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Mortality</topic><topic>Oncology</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - epidemiology</topic><topic>Pancreatic Tumors</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Fei</creatorcontrib><creatorcontrib>Yan, Ying</creatorcontrib><creatorcontrib>Ge, Chunlin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Fei</au><au>Yan, Ying</au><au>Ge, Chunlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Impact of Frailty in Pancreatic Cancer: A Systematic Review and Meta-Analysis Based on 35,191 Patients</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2024</date><risdate>2024</risdate><volume>31</volume><issue>1</issue><spage>535</spage><epage>544</epage><pages>535-544</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Frailty has been associated with increased mortality among patients with pancreatic cancer. Nevertheless, several lines of evidence regarding the prevalence of frailty in patients with pancreatic cancer and mortality in patients with pancreatic cancer and frailty have not been thoroughly investigated and require clarification.
Methods
A systematic review and meta-analysis of studies indexed in PubMed, Scopus, Web of Science, and Embase through March 2023 were conducted, and the pooled prevalence and relative risk (RR) estimate were calculated.
Results
A total of 18 studies containing 35,191 patients with pancreatic cancer were included. The prevalence of frailty in pancreatic cancer was 45% (95% CI = 29–62;
I
2
= 99.9%;
p
= 0.000). In patients with pancreatic cancer, frailty was associated with increased relative risk for mortality (RR = 1.70; 95% CI = 1.30–2.22;
I
2
= 84.8%,
p
= 0.000).
Conclusions
Frailty prevalence in pancreatic cancer is common and exerts a significant negative impact on the survival of patients with pancreatic cancer. Our findings are characterized by significant heterogeneity, and caution is warranted in their interpretation. However, these findings highlight the importance of evaluating frailty, which may provide prognostic data and inform decision-making priorities.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37899415</pmid><doi>10.1245/s10434-023-14426-y</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2024, Vol.31 (1), p.535-544 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2884182086 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Decision making Frail Elderly Frailty Frailty - epidemiology Humans Medicine Medicine & Public Health Meta-analysis Mortality Oncology Pancreatic cancer Pancreatic Neoplasms - epidemiology Pancreatic Tumors Prevalence Prognosis Surgery Surgical Oncology Systematic review |
| title | Prevalence and Impact of Frailty in Pancreatic Cancer: A Systematic Review and Meta-Analysis Based on 35,191 Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T02%3A35%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevalence%20and%20Impact%20of%20Frailty%20in%20Pancreatic%20Cancer:%20A%20Systematic%20Review%20and%20Meta-Analysis%20Based%20on%2035,191%20Patients&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Zhang,%20Fei&rft.date=2024&rft.volume=31&rft.issue=1&rft.spage=535&rft.epage=544&rft.pages=535-544&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-023-14426-y&rft_dat=%3Cproquest_cross%3E2884182086%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2897517825&rft_id=info:pmid/37899415&rfr_iscdi=true |