Low levels of CD26 on certain cellular subtypes of donor harvest is associated with better clinical outcomes post allogeneic stem cell transplantation through regulation of NF-κB pathway and pro-inflammatory cytokines

•Donor harvest CD26 expression associates positively with risk of cGVHD incidence.•Donor harvest CD26+ NK/B/Treg cells correlated negatively with patient survival.•Mechanistically, CD26 inhibitor showed dose-dependent reduction in CD26 activity.•CD26 inhibition hampered T cell activation and cytokin...

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Veröffentlicht in:	International immunopharmacology 2023-12, Vol.125 (Pt A), p.111054-111054, Article 111054
Hauptverfasser:	Kandekar, Shruti, Punatar, Sachin, Khattry, Navin, Gokarn, Anant, Jindal, Nishant, Mirgh, Sumeet, Chichra, Akanksha, Tembhare, Prashant, Rane, Pallavi, Gawde, Jitendra, Mathew, Libin, Patil, Anand, Chiplunkar, Shubhada, Kode, Jyoti
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines Dipeptidyl Peptidase 4 Graft vs Host Disease Hematopoietic Stem Cell Transplantation - adverse effects Humans NF-kappa B Tissue Donors
Online-Zugang:	Volltext
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