TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice

TW68 effectively lowers blood glucose by stabilizing CRY, inhibiting glucagon-induced gluconeogenesis through reduced Pck1 and G6pc transcription, highlighting its therapeutic potential for type 2 diabetes management. [Display omitted] Cryptochromes (CRYs), transcriptional repressors of the circadia...

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Veröffentlicht in:	Biochemical pharmacology 2023-12, Vol.218, p.115896-115896, Article 115896
Hauptverfasser:	Surme, Saliha, Ergun, Cagla, Gul, Seref, Akyel, Yasemin Kubra, Gul, Zeynep Melis, Ozcan, Onur, Ipek, Ozgecan Savlug, Akarlar, Busra Aytul, Ozlu, Nurhan, Taskin, Ali Cihan, Turkay, Metin, Gören, Ahmet Ceyhan, Baris, Ibrahim, Ozturk, Nuri, Guzel, Mustafa, Aydin, Cihan, Okyar, Alper, Kavakli, Ibrahim Halil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose Circadian Clocks Circadian rhythm Circadian Rhythm - physiology Cryptochrome Cryptochromes - genetics Diabetes Mellitus, Type 2 - drug therapy Drug discovery Fasting Glucagon Mammals Mice Mice, Obese Pharmacodynamic Pharmacokinetic Small molecule Toxicity Type 2 diabetes
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