Phase separation modulates the functional amyloid assembly of human CPEB3

How functional amyloids are regulated to restrict their activity is poorly understood. The cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is an RNA-binding protein that adopts an amyloid state key for memory persistence. Its monomer represses the translation of synaptic target mRNAs w...

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Veröffentlicht in:	Progress in neurobiology 2023-12, Vol.231, p.102540-102540, Article 102540
Hauptverfasser:	de Mingo, Daniel Ramírez, López-García, Paula, Vaquero, María Eugenia, Hervás, Rubén, Laurents, Douglas V., Carrión-Vázquez, Mariano
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Amyloid - chemistry Amyloid - metabolism CPEB3 Humans hydrogel LLPS memory RNA-Binding Proteins - metabolism
Online-Zugang:	Volltext
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