High-fat diet induces cognitive impairment through repression of SIRT1/AMPK-mediated autophagy

Recent evidence suggests an association between a high-fat diet (HFD) and cognitive decline. HFD may reduce synaptic plasticity and cause tau hyperphosphorylation, but the mechanisms involved remain unclear. The purpose of this study was to explore whether Sirtuin1 (SIRT1)/AMP-activated protein kina...

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Veröffentlicht in:	Experimental neurology 2024-01, Vol.371, p.114591-114591, Article 114591
Hauptverfasser:	Yi, Wenmin, Chen, Fei, Yuan, Minghao, Wang, Chuanling, Wang, Shengyuan, Wen, Jie, Zou, Qian, Pu, Yinshuang, Cai, Zhiyou
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - metabolism Animals Autophagy Cognitive Dysfunction - etiology Diet, High-Fat - adverse effects Mice Mice, Inbred C57BL Sirtuin 1 - metabolism tau Proteins - pharmacology
Online-Zugang:	Volltext
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