Unveiling novel RNA viruses in trematodes parasitizing common periwinkle: Implications for host-parasite interactions
[Display omitted] •New viruses are identified in parasitic flatworms.•Hypothesis of 'host-driven viral patterns' in trematodes is suggested.•Rabies-like virus in H. elongata suggests potential neurological effects. This study characterized novel RNA viruses, parasites of parasites, or hype...
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| Veröffentlicht in: | Journal of invertebrate pathology 2023-11, Vol.201, p.108012, Article 108012 |
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| container_title | Journal of invertebrate pathology |
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| creator | Gorbushin, Alexander M. |
| description | [Display omitted]
•New viruses are identified in parasitic flatworms.•Hypothesis of 'host-driven viral patterns' in trematodes is suggested.•Rabies-like virus in H. elongata suggests potential neurological effects.
This study characterized novel RNA viruses, parasites of parasites, or hyperparasites identified during transcriptomic analyses of two trematode species, Cryptocotyle lingua and Himasthla elongata, infecting a sea snail, Littorina littorea. According to the viral genome structures and phylogenetic analysis, Cryptolin alternavirus (ClRNAV1), Cryptolin calicivirus (ClRNAV2) and Himastelon rhabdovirus 1 (HeRNAV1) were respectively classified within the families Alternaviridae, Caliciviridae and Rhabdoviridae. They replicate species-specifically in two studied phases of trematode live cycle: intramolluscan parthenogenetic rediae and free-swimming cercariae. ClRNAV1 showed significantly higher expression in C. lingua cercariae relative to rediae. HeRNAV1's similarity to rabies viruses raises questions about its potential effects on the nervous system of H. elongata. This 'trematode rabies' could enable the use of genetically modified viruses for developing new methods to control the spread and intensity of diseases caused by trematodes. |
| doi_str_mv | 10.1016/j.jip.2023.108012 |
| format | Article |
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•New viruses are identified in parasitic flatworms.•Hypothesis of 'host-driven viral patterns' in trematodes is suggested.•Rabies-like virus in H. elongata suggests potential neurological effects.
This study characterized novel RNA viruses, parasites of parasites, or hyperparasites identified during transcriptomic analyses of two trematode species, Cryptocotyle lingua and Himasthla elongata, infecting a sea snail, Littorina littorea. According to the viral genome structures and phylogenetic analysis, Cryptolin alternavirus (ClRNAV1), Cryptolin calicivirus (ClRNAV2) and Himastelon rhabdovirus 1 (HeRNAV1) were respectively classified within the families Alternaviridae, Caliciviridae and Rhabdoviridae. They replicate species-specifically in two studied phases of trematode live cycle: intramolluscan parthenogenetic rediae and free-swimming cercariae. ClRNAV1 showed significantly higher expression in C. lingua cercariae relative to rediae. HeRNAV1's similarity to rabies viruses raises questions about its potential effects on the nervous system of H. elongata. This 'trematode rabies' could enable the use of genetically modified viruses for developing new methods to control the spread and intensity of diseases caused by trematodes.</description><identifier>ISSN: 0022-2011</identifier><identifier>ISSN: 1096-0805</identifier><identifier>EISSN: 1096-0805</identifier><identifier>DOI: 10.1016/j.jip.2023.108012</identifier><identifier>PMID: 37898363</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Host-Parasite Interactions ; Humans ; hyperparasitism ; Mollusca ; Phylogeny ; RNA Viruses - genetics ; Snails - parasitology ; Trematoda ; Trematoda - genetics ; Vinca ; viruses</subject><ispartof>Journal of invertebrate pathology, 2023-11, Vol.201, p.108012, Article 108012</ispartof><rights>2023</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c305t-dc330e0b4034d16f79052c127fd84d8ffabeffbaf9041729c454d20ce357f21e3</cites><orcidid>0000-0002-9324-6434</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37898363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorbushin, Alexander M.</creatorcontrib><title>Unveiling novel RNA viruses in trematodes parasitizing common periwinkle: Implications for host-parasite interactions</title><title>Journal of invertebrate pathology</title><addtitle>J Invertebr Pathol</addtitle><description>[Display omitted]
•New viruses are identified in parasitic flatworms.•Hypothesis of 'host-driven viral patterns' in trematodes is suggested.•Rabies-like virus in H. elongata suggests potential neurological effects.
This study characterized novel RNA viruses, parasites of parasites, or hyperparasites identified during transcriptomic analyses of two trematode species, Cryptocotyle lingua and Himasthla elongata, infecting a sea snail, Littorina littorea. According to the viral genome structures and phylogenetic analysis, Cryptolin alternavirus (ClRNAV1), Cryptolin calicivirus (ClRNAV2) and Himastelon rhabdovirus 1 (HeRNAV1) were respectively classified within the families Alternaviridae, Caliciviridae and Rhabdoviridae. They replicate species-specifically in two studied phases of trematode live cycle: intramolluscan parthenogenetic rediae and free-swimming cercariae. ClRNAV1 showed significantly higher expression in C. lingua cercariae relative to rediae. HeRNAV1's similarity to rabies viruses raises questions about its potential effects on the nervous system of H. elongata. This 'trematode rabies' could enable the use of genetically modified viruses for developing new methods to control the spread and intensity of diseases caused by trematodes.</description><subject>Animals</subject><subject>Host-Parasite Interactions</subject><subject>Humans</subject><subject>hyperparasitism</subject><subject>Mollusca</subject><subject>Phylogeny</subject><subject>RNA Viruses - genetics</subject><subject>Snails - parasitology</subject><subject>Trematoda</subject><subject>Trematoda - genetics</subject><subject>Vinca</subject><subject>viruses</subject><issn>0022-2011</issn><issn>1096-0805</issn><issn>1096-0805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vVCEYhYmxsWPbH-DGsHRzpy9wP3XVNH40aTQxdk0YeKmM98IVuNPUXy_TGbt0BSec8yQ8hLxhsGbA2svteuvmNQcuSu6B8RdkxWBoqxKal2QFwHnFgbFT8jqlLZRb0w6vyKno-qEXrViR5c7v0I3O31MfdjjS71-v6M7FJWGiztMccVI5mJJmFVVy2f3Zl3WYpuDpjNE9OP9rxPf0ZppHp1V2wSdqQ6Q_Q8rVcYUFljEq_fR8Tk6sGhNeHM8zcvfp44_rL9Xtt88311e3lRbQ5MpoIQBhU4OoDWttN0DDNeOdNX1temvVBq3dKDtAzTo-6LqpDQeNouksZyjOyLsDd47h94Ipy8kljeOoPIYlSd73oul5wZYqO1R1DClFtHKOblLxUTKQe9tyK4ttubctD7bL5u0Rv2wmNM-Lf3pL4cOhgOWTO4dRJu3QazQuos7SBPcf_F_h-pKR</recordid><startdate>202311</startdate><enddate>202311</enddate><creator>Gorbushin, Alexander M.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9324-6434</orcidid></search><sort><creationdate>202311</creationdate><title>Unveiling novel RNA viruses in trematodes parasitizing common periwinkle: Implications for host-parasite interactions</title><author>Gorbushin, Alexander M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-dc330e0b4034d16f79052c127fd84d8ffabeffbaf9041729c454d20ce357f21e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Host-Parasite Interactions</topic><topic>Humans</topic><topic>hyperparasitism</topic><topic>Mollusca</topic><topic>Phylogeny</topic><topic>RNA Viruses - genetics</topic><topic>Snails - parasitology</topic><topic>Trematoda</topic><topic>Trematoda - genetics</topic><topic>Vinca</topic><topic>viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gorbushin, Alexander M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of invertebrate pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorbushin, Alexander M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unveiling novel RNA viruses in trematodes parasitizing common periwinkle: Implications for host-parasite interactions</atitle><jtitle>Journal of invertebrate pathology</jtitle><addtitle>J Invertebr Pathol</addtitle><date>2023-11</date><risdate>2023</risdate><volume>201</volume><spage>108012</spage><pages>108012-</pages><artnum>108012</artnum><issn>0022-2011</issn><issn>1096-0805</issn><eissn>1096-0805</eissn><abstract>[Display omitted]
•New viruses are identified in parasitic flatworms.•Hypothesis of 'host-driven viral patterns' in trematodes is suggested.•Rabies-like virus in H. elongata suggests potential neurological effects.
This study characterized novel RNA viruses, parasites of parasites, or hyperparasites identified during transcriptomic analyses of two trematode species, Cryptocotyle lingua and Himasthla elongata, infecting a sea snail, Littorina littorea. According to the viral genome structures and phylogenetic analysis, Cryptolin alternavirus (ClRNAV1), Cryptolin calicivirus (ClRNAV2) and Himastelon rhabdovirus 1 (HeRNAV1) were respectively classified within the families Alternaviridae, Caliciviridae and Rhabdoviridae. They replicate species-specifically in two studied phases of trematode live cycle: intramolluscan parthenogenetic rediae and free-swimming cercariae. ClRNAV1 showed significantly higher expression in C. lingua cercariae relative to rediae. HeRNAV1's similarity to rabies viruses raises questions about its potential effects on the nervous system of H. elongata. This 'trematode rabies' could enable the use of genetically modified viruses for developing new methods to control the spread and intensity of diseases caused by trematodes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37898363</pmid><doi>10.1016/j.jip.2023.108012</doi><orcidid>https://orcid.org/0000-0002-9324-6434</orcidid></addata></record> |
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| language | eng |
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| subjects | Animals Host-Parasite Interactions Humans hyperparasitism Mollusca Phylogeny RNA Viruses - genetics Snails - parasitology Trematoda Trematoda - genetics Vinca viruses |
| title | Unveiling novel RNA viruses in trematodes parasitizing common periwinkle: Implications for host-parasite interactions |
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